{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:43:32Z","timestamp":1787010212670,"version":"build-2736575974"},"reference-count":20,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2011,4,1]],"date-time":"2011-04-01T00:00:00Z","timestamp":1301616000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2011,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>Pediatric Rome III criteria of functional dyspepsia (FD) has eliminated the mandatory use of upper endoscopy and recommended a symptom\u2010based approach. In the absence of alarm symptoms, FD can be positively diagnosed in children having normal physical findings without exclusionary investigations. We aimed to investigate the effectiveness of Rome III guidelines to discriminate organic diseases from FD and to identify the predictors for positive endoscopic findings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods:<\/jats:title>\n                    <jats:p>A prospective study was conducted on consecutive children fulfilling Rome III criteria of FD. Upper endoscopy was performed in all subjects, both with and without alarm features.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Eighty consecutive children ages 7 to 15 were recruited. Nine (11.3%) had experienced alarm features. Five (6.3%) had organic diseases confirmed in upper endoscopy: duodenal ulcer (n = 2), duodenitis with erosion (n = 2), and gastritis with erosion (n = 1), 33.3% of children having alarm features had organic pathology, compared with 2.8% of those without (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.01). A male predominance (80% vs 25.3%,\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.01), higher prevalence of alarm features (60% vs 8%,\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.01), and higher prevalence of\n                      <jats:italic>Helicobacter pylori<\/jats:italic>\n                      infection (80% vs 5.3%,\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.01) were found in children with organic diseases, compared with FD. Multivariate analysis identified\n                      <jats:italic>H pylori<\/jats:italic>\n                      infection (odds ratio 23.2; 95% confidence interval 1.5\u2013333) and nocturnal pain (odds ratio 26.3; 95% confidence interval 1.2\u2013500) to be independent predictors for positive endoscopic findings.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>\n                      Rome III recommendations of screening dyspeptic children for alarm features and investigation for\n                      <jats:italic>H pylori<\/jats:italic>\n                      are effective to identify children who have a higher likelihood of organic diseases and require upper endoscopy before making a diagnosis of FD.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1097\/mpg.0b013e31820e2026","type":"journal-article","created":{"date-parts":[[2011,3,17]],"date-time":"2011-03-17T05:28:17Z","timestamp":1300339697000},"page":"387-391","source":"Crossref","is-referenced-by-count":28,"title":["Impact of Pediatric Rome III Criteria of Functional Dyspepsia on the Diagnostic Yield of Upper Endoscopy and Predictors for a Positive Endoscopic Finding"],"prefix":"10.1002","volume":"52","author":[{"given":"Yuk Him","family":"Tam","sequence":"first","affiliation":[{"name":"Division of Paediatric Surgery &amp; Paediatric Urology Department of Surgery China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kin Wai","family":"Chan","sequence":"additional","affiliation":[{"name":"Division of Paediatric Surgery &amp; Paediatric Urology Department of Surgery China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ka Fai","family":"To","sequence":"additional","affiliation":[{"name":"Department of Anatomical and Cellular Pathology Prince of Wales Hospital Chinese University of Hong Kong Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sing Tak","family":"Cheung","sequence":"additional","affiliation":[{"name":"Division of Paediatric Surgery &amp; Paediatric Urology Department of Surgery China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer Wai Cheung","family":"Mou","sequence":"additional","affiliation":[{"name":"Division of Paediatric Surgery &amp; Paediatric Urology Department of Surgery China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristine Kit Yi","family":"Pang","sequence":"additional","affiliation":[{"name":"Division of Paediatric Surgery &amp; Paediatric Urology Department of Surgery China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuen Shan","family":"Wong","sequence":"additional","affiliation":[{"name":"Division of Paediatric Surgery &amp; Paediatric Urology Department of Surgery China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer Dart Yin","family":"Sihoe","sequence":"additional","affiliation":[{"name":"Division of Paediatric Surgery &amp; Paediatric Urology Department of Surgery China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim Hung","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Paediatric Surgery &amp; Paediatric Urology Department of Surgery China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,4]]},"reference":[{"issue":"2","key":"e_1_2_5_2_1","first-page":"1160","article-title":"Childhood functional gastrointestinal disorders","volume":"45","author":"Rasquin\u2010Weber A","year":"1999","journal-title":"Gut"},{"key":"e_1_2_5_3_1","doi-asserted-by":"crossref","first-page":"253","DOI":"10.3928\/00904481-20090501-05","article-title":"Functional abdominal pain: all roads lead to Rome (criteria)","volume":"38","author":"Yacob D","year":"2009","journal-title":"Pediatr Ann"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.08.063"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v16.i9.1119"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e31818c5f8b"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e31818de3ab"},{"key":"e_1_2_5_8_1","doi-asserted-by":"crossref","first-page":"259","DOI":"10.3928\/00904481-20090501-06","article-title":"Navigating recurrent abdominal pain through clinical clues, red flags, and initial testing","volume":"38","author":"Noe JD","year":"2009","journal-title":"Pediatr Ann"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-200004000-00012"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1536-4801.2001.tb07516.x"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e3181d1363c"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2010.351"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.MPG.0000154661.39488.AC"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2010.04383.x"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2009.04084.x"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.MPG.0000155367.44628.21"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e318159224e"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-5378.2008.00603.x"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1155\/2005\/390932"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.epirev.a018040"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e3181bb3362"}],"container-title":["Journal of Pediatric Gastroenterology and Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1097\/MPG.0b013e31820e2026","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,4]],"date-time":"2025-03-04T10:49:28Z","timestamp":1741085368000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1097\/MPG.0b013e31820e2026"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,4]]},"references-count":20,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2011,4]]}},"alternative-id":["10.1097\/MPG.0b013e31820e2026"],"URL":"https:\/\/doi.org\/10.1097\/mpg.0b013e31820e2026","archive":["Portico"],"relation":{},"ISSN":["0277-2116","1536-4801"],"issn-type":[{"value":"0277-2116","type":"print"},{"value":"1536-4801","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,4]]}}}