{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T08:27:53Z","timestamp":1786436873466,"version":"build-2736575974"},"reference-count":21,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2011,4,1]],"date-time":"2011-04-01T00:00:00Z","timestamp":1301616000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2011,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objectives:<\/jats:title><jats:p>We evaluated the frequencies and clinical consequences of mutations in the genes encoding cationic trypsinogen, serine protease 1 (<jats:italic>PRSS1<\/jats:italic>), and serine protease inhibitor <jats:italic>Kazal<\/jats:italic> type 1 (<jats:italic>SPINK1<\/jats:italic>) in children with acute recurrent pancreatitis (ARP) and chronic pancreatitis (CP).<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods:<\/jats:title><jats:p>The study population consisted of 32 children with ARP or CP and 28 healthy controls. We analyzed clinical data and the sequences of the entire coding region and the intron\u2010exon boundaries of the <jats:italic>PRSS1<\/jats:italic> and <jats:italic>SPINK1<\/jats:italic> genes from each patient.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>Fifteen (46.9%) of the 32 patients had at least 1 <jats:italic>PRSS1<\/jats:italic> or <jats:italic>SPINK1<\/jats:italic> mutation. Four (12.5%) of the 32 patients carried the p.N29I, p.R122H, or p.N29T mutation or a p.G208A variant of the <jats:italic>PRSS1<\/jats:italic> gene in a heterozygote state. Eleven (34.4%) of the 32 patients carried either the IVS3 + 2T&gt;C or p.N34S mutation of the <jats:italic>SPINK1<\/jats:italic> gene. No <jats:italic>PRSS1<\/jats:italic> or <jats:italic>SPINK1<\/jats:italic> mutations were identified in the control group. In particular, mutations were identified in 4 of our patients who experienced pancreas divisum with CP, whereas the remaining 2 patients with pancreas divisum and ARP did not have mutation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p>The frequencies of the <jats:italic>PRSS1<\/jats:italic> and <jats:italic>SPINK1<\/jats:italic> mutations are relatively high in Korean children with ARP or CP. Mutations in the <jats:italic>PRSS1<\/jats:italic> and <jats:italic>SPINK1<\/jats:italic> genes are highly associated with the development of childhood ARP or CP. Our findings suggest that patients with genetic mutations combined with pancreas divisum tend to develop CP early.<\/jats:p><\/jats:sec>","DOI":"10.1097\/mpg.0b013e31820e2126","type":"journal-article","created":{"date-parts":[[2011,3,17]],"date-time":"2011-03-17T09:28:17Z","timestamp":1300354097000},"page":"478-481","source":"Crossref","is-referenced-by-count":51,"title":["High Incidence of <i>PRSS1<\/i> and <i>SPINK1<\/i> Mutations in Korean Children With Acute Recurrent and Chronic Pancreatitis"],"prefix":"10.1002","volume":"52","author":[{"given":"Yeoun Joo","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Pediatrics Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyung Mo","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin Ho","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beom Hee","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gu\u2010Hwan","family":"Kim","sequence":"additional","affiliation":[{"name":"Medical Genetics Clinic and Laboratory Asan Medical Center Children's Hospital University of Ulsan College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han\u2010Wook","family":"Yoo","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,4]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1746.2003.03080.x"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2007.05.050"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.14.1007"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1536-4801.2002.tb07589.x"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mpg.0000232570.48773.df"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/000992289403300205"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(52)80120-9"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.1996.v110.pm8964426"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1096-141"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/5.4.549"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/76088"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.14.995"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.2007.00813.x"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPA.0b013e31818d1b90"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mpa.0000232014.94974.75"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-006-1921-z"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0b013e3181a4e772"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2004.30834.x"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPA.0b013e318054771f"},{"key":"e_1_2_5_21_1","first-page":"125","article-title":"Proposed nomenclature and classification of the human pancreatic ducts and duodenal papillae. 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