{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T21:11:51Z","timestamp":1791321111138,"version":"4.3.1"},"reference-count":39,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2011,6,1]],"date-time":"2011-06-01T00:00:00Z","timestamp":1306886400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2011,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objectives:<\/jats:title><jats:p>This randomized controlled trial involving 110 healthy neonates studied physiological and bifidogenic effects of galactooligosaccharides (GOS), oligofructose, and long\u2010chain inulin (fructooligosaccharides, FOS) in formula.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p>Subjects were randomized to Orafti Synergy1 (50 oligofructose:50 FOS) 0.4 g\/dL or 0.8 g\/dL, GOS:FOS (90:10) 0.8 g\/dL, or a standard formula according to Good Clinical Practice guidelines. A breast\u2010fed group was included for comparison. Outcome parameters were weight, length, intake, stool characteristics, crying, regurgitation, vomiting, adverse events, and fecal bacterial population counts. Statistical analyses used nonparametric tests.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>During the first month of life, weight, length, intake, and crying increased significantly in all of the groups. Regurgitation and vomiting scores were low and similar. Stool frequency decreased significantly and similarly in all of the formula groups but was lower than in the breast\u2010fed group. All of the prebiotic groups maintained soft stools, only slightly harder than those of breast\u2010fed infants. The standard group had significantly harder stools at weeks 2 and 4 compared with 1 (<jats:italic>P<\/jats:italic> &lt; 0.001 and <jats:italic>P<\/jats:italic> = 0.0279). The total number of fecal bacteria increased in all of the prebiotic groups (9.82, 9.73, and 9.91 to 10.34, 10.38, and 10.37, respectively, log10 cells\/g feces, <jats:italic>P<\/jats:italic> = 0.2298) and more closely resembled the breast\u2010fed pattern. Numbers of lactic acid bacteria, bacteroides, and clostridia were comparable. In the SYN1 0.8 g\/dL and GOS:FOS groups, Bifidobacterium counts were significantly higher at D14 and 28 compared with D3 and were comparable with the breast\u2010fed group. Tolerance and growth were normal.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p>Stool consistency and bacterial composition of infants taking SYN1 0.8 g\/dL or GOS:FOS\u2013supplemented formula were closer to the breast\u2010fed pattern. There was no risk of dehydration.<\/jats:p><\/jats:sec>","DOI":"10.1097\/mpg.0b013e3182139f39","type":"journal-article","created":{"date-parts":[[2011,5,17]],"date-time":"2011-05-17T13:31:52Z","timestamp":1305639112000},"page":"763-771","source":"Crossref","is-referenced-by-count":135,"title":["Physiological and Bifidogenic Effects of Prebiotic Supplements in Infant Formulae"],"prefix":"10.1002","volume":"52","author":[{"given":"G","family":"Veereman\u2010Wauters","sequence":"first","affiliation":[{"name":"Department of Pediatric Gastroenterology and Nutrition, UZ Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Staelens","sequence":"additional","affiliation":[{"name":"Department of Pediatric Gastroenterology and Nutrition Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Van de Broek","sequence":"additional","affiliation":[{"name":"Department of Neonatology Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Plaskie","sequence":"additional","affiliation":[{"name":"Neonatology University Hospital Antwerp Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Wesling","sequence":"additional","affiliation":[{"name":"Department of Obstetrics Queen Paola and Middelheim Hospitals ZNA Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"LC","family":"Roger","sequence":"additional","affiliation":[{"name":"Microbial Ecology and Health Group Department of Food and Nutritional Sciences University of Reading Reading UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"AL","family":"McCartney","sequence":"additional","affiliation":[{"name":"Microbial Ecology and Health Group Department of Food and Nutritional Sciences University of Reading Reading UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Assam","sequence":"additional","affiliation":[{"name":"Center for Statistics Hasselt University Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,6]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/137.11.2585S"},{"key":"e_1_2_5_3_1","first-page":"17","article-title":"Clinical applications: prebiotic effects of infant food","volume":"2","author":"Veereman\u2010Wauters G","year":"2010","journal-title":"Functional Food Rev"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.3109\/07853899908995892"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1086\/523335"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.159.4.1739"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/0115426507022003351"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.300.6716.11"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2005.02298.x"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1006\/abio.1994.1577"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-200001000-00019"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0929-693X(98)80172-3"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1099\/00222615-15-2-189"},{"key":"e_1_2_5_14_1","first-page":"S40","article-title":"Phosphate concentration. 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