{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T20:53:47Z","timestamp":1791579227709,"version":"4.3.4"},"reference-count":42,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2012,2,1]],"date-time":"2012-02-01T00:00:00Z","timestamp":1328054400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2012,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective:<\/jats:title><jats:p>The aim of this study was to summarise the evidence from 2004 to September 2009 on the performance of laboratory\u2010based serological and point of care (POC) tests for diagnosing coeliac disease (CD) in children using histology as reference standard.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods:<\/jats:title><jats:p>We searched MEDLINE and EMBASE for studies reporting on children for tests based on IgA and IgG anti\u2010gliadin (AGA), endomysial (EmA), anti\u2010transglutaminase\u20102 (TG2), and anti\u2010deamidated gliadin peptides (DGP) antibodies or POC tests. For inclusion, histological analysis of duodenal biopsies and sensitivity and specificity for index tests had to be reported. Data were pooled and summary measures calculated for sensitivity, specificity, positive and negative likelihood ratios (\u201cLR+\u201d, \u201cLR\u2212\u201d), and diagnostic odds ratios (DOR). In case of elevated statistical heterogeneity, studies reaching 90% sensitivity or specificity were reported.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>A total of 2510 articles were reviewed; 16 entered meta\u2010analysis, reporting on 3110 patients (1876 with CD, 1234 without CD). For IgA\u2010EmA, sensitivity was \u226590% in 7\/11 studies and pooled specificity 98.2%. For IgA\u2010anti\u2010TG2, 11\/15 studies yielded sensitivities \u226590% and 13\/15 specificities \u226590%. For IgA\u2010DGP, sensitivity ranged between 80.7% and 95.1% (specificity 86.3%\u201393.1%); for IgG\u2010DGP between 80.1% and 98.6% (specificity 86.0\u201396.9%). IgA\u2010EmA had the highest pooled DOR (554) and LR+ (31.8) for a laboratory test, followed by IgA\u2010anti\u2010TG2, IgG\u2010DGP, IgA\u2010DGP and IgA\u2010AGA. POC tests showed a pooled sensitivity of 96.4% for IgA\u2010TG2 (specificity 97.7%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p>IgA\u2010EmA and IgA\u2010anti\u2010TG2 tests appear highly accurate to diagnose CD. IgG\u2010anti\u2010DGP tests may help in excluding CD. IgA\u2010AGA and IgA\u2010DGP tests show inferior accuracy. POC tests may achieve high accuracy in the hands of experienced readers, but IgA\u2010anti\u2010TG2\/EmA were superior.<\/jats:p><\/jats:sec>","DOI":"10.1097\/mpg.0b013e318216f2e5","type":"journal-article","created":{"date-parts":[[2012,1,20]],"date-time":"2012-01-20T05:11:22Z","timestamp":1327036282000},"page":"229-241","source":"Crossref","is-referenced-by-count":218,"title":["Accuracy of Diagnostic Antibody Tests for Coeliac Disease in Children"],"prefix":"10.1002","volume":"54","author":[{"given":"Klaus","family":"Giersiepen","sequence":"first","affiliation":[{"name":"Centre for Social Policy Research University of Bremen Bremen"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"Lelgemann","sequence":"additional","affiliation":[{"name":"Medical Review Board of the Statutory Health Insurance Funds (MDS) Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina","family":"Stuhldreher","sequence":"additional","affiliation":[{"name":"Centre for Social Policy Research University of Bremen Bremen"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Ronfani","sequence":"additional","affiliation":[{"name":"Epidemiology and Biostatistics Unit Institute for Maternal and Child Health IRCCS Burlo Garofolo Trieste Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steffen","family":"Husby","sequence":"additional","affiliation":[{"name":"Hans Christian Andersen Children's Hospital Odense University Hospital Odense C Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sibylle","family":"Koletzko","sequence":"additional","affiliation":[{"name":"Dr von Haunersches Kinderspital Ludwig Maximilians Universit\u00e4t M\u00fcnchen M\u00fcnchen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilma R.","family":"Korponay\u2010Szab\u00f3","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Medical and Health Science Centre University of Debrecen Debrecen Hungary"},{"name":"Heim Pal Children's Hospital Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"ESPGHAN Working Group on Coeliac Disease Diagnosis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,2]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.163.3.286"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.65.8.909"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-200501000-00001"},{"key":"e_1_2_10_5_1","unstructured":"National Institute for Clinical Excellence.CG86 coeliac disease: full guideline.http:\/\/guidance.nice.org.uk\/CG86\/Guidance\/pdf\/English. 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