{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T03:06:19Z","timestamp":1792811179438,"version":"4.5.0"},"reference-count":49,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2011,11,1]],"date-time":"2011-11-01T00:00:00Z","timestamp":1320105600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2011,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective:<\/jats:title><jats:p>The aim of the present study was to evaluate the efficacy of a milkfat globule membrane (MFGM)\u2013enriched protein fraction in a complementary food, on diarrhea, anemia, and micronutrient status.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects and Methods:<\/jats:title><jats:p>A randomized, double\u2010blind controlled design to study 550 infants, 6 to 11 months old, who received daily for 6 months a complementary food (40 g\/day) with the protein source being either the MFGM protein fraction or skim milk proteins (control). Health and nutritional status of infants were examined monthly in the outpatient clinic; product intake, food patterns, and diarrhea morbidity were assessed by home visits twice per week. Hemoglobin and micronutrient status were measured at 0 and 6 months of intervention. Results are presented as the entire group and as 6 to 8 and 9 to 11 months subgroups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>A total of 499 infants completed the study. Global prevalence of diarrhea was 3.84% and 4.37% in the MFGM group and control group, respectively (<jats:italic>P<\/jats:italic> &lt; 0.05). Consumption of the MFGM protein fraction reduced episodes of bloody diarrhea (odds ratio 0.54; 95% confidence interval 0.31\u20130.93, <jats:italic>P<\/jats:italic> = 0.025) adjusting for anemia and potable water facilities as covariates. There were no differences between groups in anemia, serum ferritin, zinc, or folate.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p>Addition of an MFGM\u2010enriched protein fraction to complementary food had beneficial effects on diarrhea in infants and may thus help to improve the health of vulnerable populations.<\/jats:p><\/jats:sec>","DOI":"10.1097\/mpg.0b013e318225cdaf","type":"journal-article","created":{"date-parts":[[2011,6,3]],"date-time":"2011-06-03T15:45:32Z","timestamp":1307115932000},"page":"561-568","source":"Crossref","is-referenced-by-count":114,"title":["Efficacy of an MFGM\u2010enriched Complementary Food in Diarrhea, Anemia, and Micronutrient Status in Infants"],"prefix":"10.1002","volume":"53","author":[{"given":"Nelly","family":"Zavaleta","sequence":"first","affiliation":[{"name":"Instituto de Investigaci\u00f3n Nutricional Lima Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne Staudt","family":"Kvistgaard","sequence":"additional","affiliation":[{"name":"Arla Foods Ingredients Viby Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gitte","family":"Graverholt","sequence":"additional","affiliation":[{"name":"Arla Foods Ingredients Viby Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graciela","family":"Respicio","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n Nutricional Lima Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry","family":"Guija","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n Nutricional Lima Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norma","family":"Valencia","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n Nutricional Lima Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"L\u00f6nnerdal","sequence":"additional","affiliation":[{"name":"Department of Nutrition University of California Davis"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,11]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)13779-8"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/80.1.193"},{"key":"e_1_2_8_4_1","first-page":"1246","article-title":"Reducing deaths from diarrhea through oral rehydration therapy","volume":"78","author":"Victora CG","year":"2000","journal-title":"Bull WHO"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)71877-8"},{"key":"e_1_2_8_6_1","first-page":"197","article-title":"The global burden of diarrheal disease as estimated from studies published between 1992 and 2000","volume":"81","author":"Kosek M","year":"2003","journal-title":"Bull WHO"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwf179"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2002.66.590"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyn099"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/156482650302400102"},{"key":"e_1_2_8_11_1","volume-title":"Informe Principal, Mayo.","year":"2010"},{"key":"e_1_2_8_12_1","volume-title":"Final Report, (Spanish)","author":"Instituto Nacional Estad\u00edstica e Informatica, Macro International.","year":"2001"},{"issue":"2","key":"e_1_2_8_13_1","first-page":"S99","article-title":"International Zinc Nutrition Consultative Group (IZiNCG) Technical Document #1. 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