{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T17:44:42Z","timestamp":1787679882400,"version":"build-2784847793"},"reference-count":27,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2011,11,1]],"date-time":"2011-11-01T00:00:00Z","timestamp":1320105600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DK41612"],"award-info":[{"award-number":["DK41612"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DK078596"],"award-info":[{"award-number":["DK078596"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DK083762"],"award-info":[{"award-number":["DK083762"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32 DK07257"],"award-info":[{"award-number":["T32 DK07257"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2011,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Sodium absorption by the intestine is mediated by brush border Na<jats:sup>+<\/jats:sup>\/H<jats:sup>+<\/jats:sup> exchangers, which include the NHE3 and NHE8 isoforms. We demonstrated a maturational decrease in NHE8 and increase in NHE3 in mouse intestine mRNA abundance and brush border membrane protein abundance, indicating a developmental switch of isoforms. Congenital sodium diarrhea is a rare autosomal recessive disorder characterized by polyhydramnios, hyponatremia, metabolic acidosis, and diarrhea with a high sodium content. Previous studies using intestinal brush border membrane vesicles from patients with this disorder have demonstrated a decrease in Na<jats:sup>+<\/jats:sup>\/H<jats:sup>+<\/jats:sup> exchanger activity. Because some patients with congenital sodium diarrhea improve with age and knowing the developmental switch from NHE8 to NHE3, NHE8 may be a candidate gene for this disorder. We sequenced NHE8 from 5 patients with this disorder and found no disease\u2010causing homozygous mutations. Although brush border membrane Na<jats:sup>+<\/jats:sup>\/H<jats:sup>+<\/jats:sup> exchange activity may be decreased, exonic mutations in NHE8 cannot account for this disorder in these subjects.<\/jats:p>","DOI":"10.1097\/mpg.0b013e318227ad6e","type":"journal-article","created":{"date-parts":[[2011,6,10]],"date-time":"2011-06-10T12:05:32Z","timestamp":1307707532000},"page":"474-477","source":"Crossref","is-referenced-by-count":14,"title":["Nucleotide Sequence of the Na<sup>+<\/sup>\/H<sup>+<\/sup> Exchanger\u20108 in Patients With Congenital Sodium Diarrhea"],"prefix":"10.1002","volume":"53","author":[{"given":"Michel","family":"Baum","sequence":"first","affiliation":[{"name":"Department of Pediatrics Mattel Children's Hospital David Geffen School of Medicine at the University of California Los Angeles"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin G.","family":"Martin","sequence":"additional","affiliation":[{"name":"Division of Pediatric Gastroenterology, 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