{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T00:28:59Z","timestamp":1788827339727,"version":"build-2803163510"},"reference-count":5,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2011,11,1]],"date-time":"2011-11-01T00:00:00Z","timestamp":1320105600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2011,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>6\u2010Thioguanine (6\u2010TG) therapy in childhood acute lymphoblastic leukaemia results in chronic hepatotoxicity and portal hypertension. We report follow\u2010up data in a cohort of 10 children with acute lymphoblastic leukaemia and 6\u2010TG\u2010related hepatotoxicity described initially in 2006. Clinically significant portal hypertension was present in the majority of patients several years after cessation of 6\u2010TG treatment. These data reflect the natural history of noncirrhotic portal hypertension and emphasises the need to incorporate ongoing surveillance in the transition arrangement to adult services in this select group of patients.<\/jats:p>","DOI":"10.1097\/mpg.0b013e31822960e9","type":"journal-article","created":{"date-parts":[[2011,6,23]],"date-time":"2011-06-23T11:36:53Z","timestamp":1308829013000},"page":"478-479","source":"Crossref","is-referenced-by-count":19,"title":["Long\u2010term Follow\u2010up of Children With 6\u2010Thioguanine\u2010related Chronic Hepatoxicity Following Treatment for Acute Lymphoblastic Leukaemia"],"prefix":"10.1002","volume":"53","author":[{"given":"Dinesh","family":"Rawat","sequence":"first","affiliation":[{"name":"Department of Hepatology Birmingham Children's Hospital Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter M.","family":"Gillett","sequence":"additional","affiliation":[{"name":"Department of Paediatric Gastroenterology Royal Hospital for Sick Children Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Devadason","sequence":"additional","affiliation":[{"name":"Department of Paediatric Gastroenterology Royal Hospital for Sick Children Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David C.","family":"Wilson","sequence":"additional","affiliation":[{"name":"Department of Paediatric Gastroenterology Royal Hospital for Sick Children Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick J.","family":"McKiernan","sequence":"additional","affiliation":[{"name":"Department of Hepatology Birmingham Children's Hospital Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,11]]},"reference":[{"key":"e_1_2_2_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mpg.0000221901.76404.07"},{"key":"e_1_2_2_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.51.2.275"},{"key":"e_1_2_2_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2005.06.020"},{"key":"e_1_2_2_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2004.04919.x"},{"key":"e_1_2_2_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.20202"}],"container-title":["Journal of Pediatric Gastroenterology and Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1097\/MPG.0b013e31822960e9","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,18]],"date-time":"2024-01-18T12:31:19Z","timestamp":1705581079000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1097\/MPG.0b013e31822960e9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,11]]},"references-count":5,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2011,11]]}},"alternative-id":["10.1097\/MPG.0b013e31822960e9"],"URL":"https:\/\/doi.org\/10.1097\/mpg.0b013e31822960e9","archive":["Portico"],"relation":{},"ISSN":["0277-2116","1536-4801"],"issn-type":[{"value":"0277-2116","type":"print"},{"value":"1536-4801","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,11]]}}}