{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T12:02:48Z","timestamp":1762430568349},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2012,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background and Objectives:<\/jats:title><jats:p>A revision of criteria for diagnosing coeliac disease (CD) is being conducted by The European Society for Pediatric Gastroenterology, Hepatology, and Nutrition (ESPGHAN). In parallel, we have performed a survey aimed to evaluate present practices for CD among paediatric gastroenterologists and to learn their views on the need for modification of present criteria for CD diagnosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods:<\/jats:title><jats:p>Questionnaires were distributed to experienced paediatric gastroenterologists (ESPGHAN members) via the Internet.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>Overall, 95 valid questionnaires were available for analysis, pertaining to 28 different countries, with the majority of responders treating patients with CD for &gt;15 years. Only about 12% of the responders comply with present criteria, noncompliance being related mainly to the challenge policy. Approximately 90% request a revision and modification of the present criteria. Forty\u2010four percent want to omit the small bowel biopsy in symptomatic children with positive anti\u2010tissue transglutaminase immunoglobulin (Ig) A or endomysial IgA antibodies, especially if they are DQ2\/DQ8 positive. For silent cases detected by screening with convincingly positive anti\u2010tissue transglutaminase IgA or EMA IgA, about 30% consider that no small bowel biopsy should be required in selected cases. Adding human leukocyte antigen typing in the diagnostic workup was asked for by 42% of the responders. As for gluten challenge, a new policy is advocated restricting its obligation to cases whenever the diagnosis is doubtful or unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p>Based on these opinions, revision of the ESPGHAN criteria for diagnosing CD is urgently needed.<\/jats:p><\/jats:sec>","DOI":"10.1097\/mpg.0b013e31822a00bb","type":"journal-article","created":{"date-parts":[[2011,6,30]],"date-time":"2011-06-30T18:31:14Z","timestamp":1309458674000},"page":"15-19","source":"Crossref","is-referenced-by-count":32,"title":["Coeliac Disease Diagnosis"],"prefix":"10.1002","volume":"54","author":[{"given":"C.","family":"Ribes\u2010Koninckx","sequence":"first","affiliation":[{"name":"Pediatric Gastroenterology Unit La Fe University Hospital Valencia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ML.","family":"Mearin","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Leiden University Medical Center Leiden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"IR.","family":"Korponay\u2010Szab\u00f3","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Medical and Health Science Centre University of Debrecen Nagyerdei, Debrecen, and Heim Pal Children's Hospital Budapest Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Shamir","sequence":"additional","affiliation":[{"name":"Institute of Gastroenterology Nutrition and Liver Disease Schneider Children's Medical Center of Israel Tel\u2010Aviv University Tel\u2010Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Husby","sequence":"additional","affiliation":[{"name":"Hans Christian Andersen Children's Hospital Odense University Hospital Odense C Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Ventura","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Institute for Child Health IRCCS Burlo Garofolo University of Trieste Trieste Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Branski","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Hadassah University Hospitals Jerusalem Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Catassi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Universit\u00e0 Politecnica delle Marche Ancona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Koletzko","sequence":"additional","affiliation":[{"name":"Dr von Haunersches Kinderspital Ludwig Maximilians Universit\u00e4t M\u00fcnchen Lindwurmstr M\u00fcnchen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"M\u00e4ki","sequence":"additional","affiliation":[{"name":"Pediatric Research Center University of Tampere and Tampere University Hospital Tampere 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