{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T14:33:39Z","timestamp":1792074819112,"version":"4.4.0"},"reference-count":22,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2011,12,1]],"date-time":"2011-12-01T00:00:00Z","timestamp":1322697600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2011,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objectives:<\/jats:title><jats:p>Liver hemangiomas are vascular tumors, which occur in the first months of life and carry risks of initial complications, but are considered to be benign histologically and to regress with time. Histologic studies suggest that a subtype, type 2 hemangioendothelioma, is akin to angiosarcoma and may have a severe long\u2010term prognosis. We report 5 girls with type 2 hemangioendothelioma of the liver.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results:<\/jats:title><jats:p>Three children initially presented with classical infantile multinodular hemangioma, including cardiac and pulmonary complications and regression of tumors at age 1\u00bd to 2\u00bd years. All 3 experienced tumor relapse at ages 2\u00bd to 3, leading to death at ages 2\u00bd to 5. Tumor histology showed type 2 hemangioendothelioma. The other 2 children presented with liver tumors at ages 2 and 3 years. In 1, initial biopsy of a single tumor showed benign type 1 hemangioendothelioma, but surgical resection was followed by relapse in the remaining liver, lung metastases, and death. Whole tumor histology showed both type 1 and 2 lesions. In the other child, tumor biopsy showed type 2 lesions. She underwent liver transplantation and is alive without tumor recurrence 3 years later.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p>Careful follow\u2010up is necessary to detect late recurrence in infants with multinodular liver hemangiomas. Vascular liver tumors occurring after infancy are likely to be malignant. The high risk of relapse in the remaining liver suggests that if no metastases are detected, liver transplantation is preferable to surgical tumor resection in both situations.<\/jats:p><\/jats:sec>","DOI":"10.1097\/mpg.0b013e318230146c","type":"journal-article","created":{"date-parts":[[2011,10,4]],"date-time":"2011-10-04T20:58:48Z","timestamp":1317761928000},"page":"615-619","source":"Crossref","is-referenced-by-count":25,"title":["Widening Spectrum of Liver Angiosarcoma in Children"],"prefix":"10.1002","volume":"53","author":[{"given":"Oanez","family":"Ackermann","sequence":"first","affiliation":[{"name":"Service d\u2019H\u00e9patologie P\u00e9diatrique H\u00f4pital Bic\u00eatre Assistance Publique\u2010H\u00f4pitaux de Paris, and Universit\u00e9 Paris Sud 11 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monique","family":"Fabre","sequence":"additional","affiliation":[{"name":"Service d\u2019Anatomopathologie H\u00f4pital Bic\u00eatre Assistance Publique\u2010H\u00f4pitaux de Paris, and Universit\u00e9 Paris Sud 11 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Franchi","sequence":"additional","affiliation":[{"name":"Service de Radiologie P\u00e9diatrique H\u00f4pital Bic\u00eatre Assistance Publique\u2010H\u00f4pitaux de Paris, and Universit\u00e9 Paris Sud 11 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele","family":"Pariente","sequence":"additional","affiliation":[{"name":"Service de Radiologie P\u00e9diatrique H\u00f4pital Bic\u00eatre Assistance Publique\u2010H\u00f4pitaux de Paris, and Universit\u00e9 Paris Sud 11 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Debray","sequence":"additional","affiliation":[{"name":"Service d\u2019H\u00e9patologie P\u00e9diatrique H\u00f4pital Bic\u00eatre Assistance Publique\u2010H\u00f4pitaux de Paris, and Universit\u00e9 Paris Sud 11 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel","family":"Jacquemin","sequence":"additional","affiliation":[{"name":"Service d\u2019H\u00e9patologie P\u00e9diatrique H\u00f4pital Bic\u00eatre Assistance Publique\u2010H\u00f4pitaux de Paris, and Universit\u00e9 Paris Sud 11 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederic","family":"Gauthier","sequence":"additional","affiliation":[{"name":"Service de Chirurgie P\u00e9diatrique H\u00f4pital Bic\u00eatre Assistance Publique\u2010H\u00f4pitaux de Paris, and Universit\u00e9 Paris Sud 11 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Bernard","sequence":"additional","affiliation":[{"name":"Service d\u2019H\u00e9patologie P\u00e9diatrique H\u00f4pital Bic\u00eatre Assistance Publique\u2010H\u00f4pitaux de Paris, and Universit\u00e9 Paris Sud 11 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,12]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840200108"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2008.10.021"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19890815)64:4<936::AID-CNCR2820640429>3.0.CO;2-J"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2006.09.041"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3046.2004.00268.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.3109\/15513819209024199"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(83)80005-7"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-2277.2010.01107.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2559.1996.d01-414.x"},{"key":"e_1_2_6_11_1","first-page":"101","article-title":"Vascular tumors of the liver in infants and children. 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