{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,1,19]],"date-time":"2024-01-19T00:09:37Z","timestamp":1705622977724},"reference-count":7,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,3,1]],"date-time":"2012-03-01T00:00:00Z","timestamp":1330560000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2012,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Aim:<\/jats:title><jats:p>The aim of the present study was to compare the Biohit Lactose Intolerance Quick Test (BLIQT) to the criterion standard biochemical duodenal lactase (DL) activity assay in the paediatric population using standard statistical comparative tests.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p>Using standard Olympus endoscopes, 2 postbulbar duodenal biopsies were taken from 38 prospective children (0\u201316 years) from June 2008\u2013May 2009 at a single tertiary paediatric gastroenterology unit. The biopsies were used for the BLIQT and for biochemical disaccharides assay.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>Thirty\u2010eight children (19 boys) of median age 5.45 years (0.3\u201314.8 years) underwent the combined BLIQT and disaccharidase testing. We subdivided the group into those who had biopsies with a larger endoscope (XQ, n = 26) and those who had a smaller endoscope (XP, n = 12) and thus a smaller biopsy forcep. When using a larger endoscope, the BLIQT showed a sensitivity of 100%, specificity of 86%, and positive and negative predictive value of 57.1% and 100%, respectively, on comparing it with DL. With a smaller endoscope, the BLIQT had a sensitivity of 100%, specificity of 80%, positive predictive value of 50%, and a negative predictive value of 100%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p>As in adult studies, the sensitivity and negative predictive value of the BLIQT was 100%. The specificity too appears to be high but variable, probably because of smaller biopsies obtained, and may warrant the need for 2 biopsies. The high sensitivity, specificity, and negative predictive value of the BLIQT for indicating hypolactasia make it an effective point\u2010of\u2010care test for paediatric hypolactasia.<\/jats:p><\/jats:sec>","DOI":"10.1097\/mpg.0b013e318231eb30","type":"journal-article","created":{"date-parts":[[2011,10,4]],"date-time":"2011-10-04T20:58:48Z","timestamp":1317761928000},"page":"401-403","source":"Crossref","is-referenced-by-count":8,"title":["Comparison of Quick Point\u2010of\u2010Care Test for Small\u2010bowel Hypolactasia With Biochemical Lactase Assay in Children"],"prefix":"10.1002","volume":"54","author":[{"given":"Prithviraj","family":"Rao","sequence":"first","affiliation":[{"name":"Department of Paediatric Gastroenterology Sheffield Children's Hospital NHS Foundation Trust Sheffield UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nagendra","family":"Rao","sequence":"additional","affiliation":[{"name":"Department of Paediatric Gastroenterology Sheffield Children's Hospital NHS Foundation Trust Sheffield UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew","family":"Jordinson","sequence":"additional","affiliation":[{"name":"Clinical Biochemistry Units Sheffield Children's Hospital NHS Foundation Trust Sheffield UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camilla","family":"Scott","sequence":"additional","affiliation":[{"name":"Clinical Biochemistry Units Sheffield Children's Hospital NHS Foundation Trust Sheffield UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carol","family":"Hinchcliffe","sequence":"additional","affiliation":[{"name":"Clinical Biochemistry Units Sheffield Children's Hospital NHS Foundation Trust Sheffield UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Campbell","sequence":"additional","affiliation":[{"name":"Department of Paediatric Gastroenterology Sheffield Children's Hospital NHS Foundation Trust Sheffield UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,3]]},"reference":[{"issue":"4","key":"e_1_2_9_2_1","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1093\/ajcn\/48.4.1142","article-title":"The acceptability of milk and milk products in populations with a high prevalence of lactose intolerance","volume":"48","author":"Scrimshaw NS","year":"1988","journal-title":"Am J Clin Nutr"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2004.040048"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1975.tb03906.x"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365529409091742"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-925354"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(66)90280-6"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.5521.1037"}],"container-title":["Journal of Pediatric Gastroenterology and Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1097\/MPG.0b013e318231eb30","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,18]],"date-time":"2024-01-18T12:52:07Z","timestamp":1705582327000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1097\/MPG.0b013e318231eb30"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,3]]},"references-count":7,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2012,3]]}},"alternative-id":["10.1097\/MPG.0b013e318231eb30"],"URL":"https:\/\/doi.org\/10.1097\/mpg.0b013e318231eb30","archive":["Portico"],"relation":{},"ISSN":["0277-2116","1536-4801"],"issn-type":[{"value":"0277-2116","type":"print"},{"value":"1536-4801","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,3]]}}}