{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T06:02:26Z","timestamp":1791352946469,"version":"4.3.1"},"reference-count":21,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2012,2,1]],"date-time":"2012-02-01T00:00:00Z","timestamp":1328054400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2012,2]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background:<\/jats:title>\n Cholestatic jaundice and liver enzyme abnormalities have been reported in neonatal septicaemia; the course, pattern, and outcome of such hepatobiliary dysfunction have not been described.<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n One hundred fifty\u2010three neonates with blood culture\u2013positive sepsis were recruited from the neonatal intensive care unit of an urban hospital. Liver function tests were done on day 3 and day 10 in all of the cases. In babies with abnormal results (direct bilirubin >20% of total with a minimum level of 2 mg\/dL or alanine aminotransferase [ALT] >50 U\/L), tests were repeated weekly for 1 month and then fortnightly for 3 months or until normalization of values. Anthropometry was recorded at all of these visits.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n Klebsiella pneumoniae<\/jats:italic>\n was the commonest organism, isolated in 95.4% of subjects. Eighty\u2010three (54.2%) subjects had hepatobiliary dysfunction in the form of either cholestatic jaundice (n = 65 [42.5%]) or derangement in ALT (n = 57 [37.3%]). The onset of cholestasis was seen by day 3 of sepsis in 80% (n = 52), with maximum value of direct bilirubin seen by the 10th day in 90% (n = 58). Only 15% (n = 10) continued to have cholestatic jaundice beyond 30 days of onset of sepsis, and it resolved by 60 days. Hepatic enzyme abnormalities followed a more protracted course: onset by day 10 in 95%, peak value by day 38 in 90%, and normalisation by 60 days in 82% of subjects. The prevalence of any hepatobiliary dysfunction was found less frequently in babies who died as compared with survivors (43.4% vs 56.7%;\n P<\/jats:italic>\n < 0.01). The weight, length, and head circumference during follow\u2010up visits were comparable between neonates with or without hepatobiliary dysfunction.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions:<\/jats:title>\n Hepatobiliary dysfunction is common in Gram\u2010negative neonatal septicaemia. The onset of abnormalities is early in most cases but ultimately resolve within 2 to 3 months after sepsis. The presence of conjugated hyperbilirubinemia in neonatal sepsis may carry a better prognosis in terms of survival and has no significant effect on growth during early infancy.<\/jats:p>\n <\/jats:sec>","DOI":"10.1097\/mpg.0b013e318233d33d","type":"journal-article","created":{"date-parts":[[2011,10,4]],"date-time":"2011-10-04T16:58:48Z","timestamp":1317747528000},"page":"218-222","source":"Crossref","is-referenced-by-count":23,"title":["Prevalence and Outcome of Hepatobiliary Dysfunction in Neonatal Septicaemia"],"prefix":"10.1002","volume":"54","author":[{"given":"Sumaira","family":"Khalil","sequence":"first","affiliation":[{"name":"Department of Paediatrics University College of Medical Sciences University of Delhi and GTB Hospital Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dheeraj","family":"Shah","sequence":"additional","affiliation":[{"name":"Department of Paediatrics University College of Medical Sciences University of Delhi and GTB Hospital Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.M.A.","family":"Faridi","sequence":"additional","affiliation":[{"name":"Department of Paediatrics University College of Medical Sciences University of Delhi and GTB Hospital Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashwani","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Microbiology University College of Medical Sciences University of Delhi and GTB Hospital Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiran","family":"Mishra","sequence":"additional","affiliation":[{"name":"Department of Pathology University College of Medical Sciences University of Delhi and GTB Hospital Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,2]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)61461-4"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)60549-1"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-200006000-00001"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00442511"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(05)82056-6"},{"key":"e_1_2_5_7_1","volume-title":"Sample Size Determination in Health Studies: A Practical Manual","author":"Lwanga SK","year":"1991"},{"key":"e_1_2_5_8_1","first-page":"343","article-title":"Bacteriological analysis of blood culture isolates from neonates in a tertiary care hospital in India","volume":"20","author":"Kumhar GD","year":"2002","journal-title":"J Health Popul 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