{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T13:02:54Z","timestamp":1791378174839,"version":"4.3.2"},"reference-count":18,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2012,5,1]],"date-time":"2012-05-01T00:00:00Z","timestamp":1335830400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2012,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective:<\/jats:title><jats:p>The aim of the study was to investigate whether recurrent abdominal pain (RAP) in <jats:italic>Blastocystis hominis<\/jats:italic>\u2013positive children can be treated successfully with trimethoprim\u2010sulfamethoxazole (TMP\/SMX).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p>From October 2004 to December 2008, all of the patients referred to the Division of Gastroenterology and Nutrition of the University Children's Hospital Zurich because of RAP and detection of <jats:italic>B hominis<\/jats:italic> in stool samples as the only pathological finding after a standard workup were offered to participate in the study. Patients were randomly assigned into 2 groups. TMP\/SMX or placebo was given for 7 days in a double\u2010blind, placebo\u2010controlled manner. Pain index (PI) was measured with a visual analogue scale. Two weeks after completion of treatment, 3 stool samples were collected and patients were followed clinically. If <jats:italic>B hominis<\/jats:italic> was still present, metronidazole was given for 7 days.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>Forty patients were included; 37 finished the study (TMP\/SMX n = 20, placebo n = 17). Mean PI declined from 7.1 to 3.6 for all of the patients, with a decrease from 6.9 to 4.1 in the TMP\/SMX and 7.4 to 3.0 in the placebo group, irrespective of detection of <jats:italic>B hominis<\/jats:italic> after treatment. There was no statistically significant difference in PI reduction between the 2 groups. Metronidazole treatment led to a further PI decline from 3.7 to 1.9. Eradication rates were 35% (TMP\/SMX) and 44% (metronidazole), compared with spontaneous clearance of 29% in the placebo group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p>There is no advantage for TPM\/SMX over placebo in the treatment of RAP in <jats:italic>B hominis<\/jats:italic>\u2013positive children.<\/jats:p><\/jats:sec>","DOI":"10.1097\/mpg.0b013e31823a29a7","type":"journal-article","created":{"date-parts":[[2011,10,15]],"date-time":"2011-10-15T09:25:41Z","timestamp":1318670741000},"page":"677-679","source":"Crossref","is-referenced-by-count":29,"title":["No Advantage for Antibiotic Treatment Over Placebo in <i>Blastocystis hominis<\/i>\u2013positive Children With Recurrent Abdominal Pain"],"prefix":"10.1002","volume":"54","author":[{"given":"Klaas","family":"Heyland","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Nutrition University Children's Hospital Zurich Z\u00fcrich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Friedt","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Nutrition University Children's Hospital Zurich Z\u00fcrich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Buehr","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Nutrition University Children's Hospital Zurich Z\u00fcrich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian P.","family":"Braegger","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Nutrition University Children's Hospital Zurich Z\u00fcrich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,5]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.27.11.2407-2409.1989"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(91)91668-K"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2005.03868.x"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(92)90112-G"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.1999.01529.x"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.2310\/7060.2003.31714"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00436-005-1363-1"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.33.168.165"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.32.11.2865-2866.1994"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-0960.2006.00244.x"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2002.473212.x"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/000155502753600948"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(88)90557-4"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.49.3.192"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2004.70.383"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.31.10.2706-2708.1993"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/PL00008533"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1542-3565(05)00427-1"}],"container-title":["Journal of Pediatric Gastroenterology and Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1097\/MPG.0b013e31823a29a7","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,18]],"date-time":"2024-01-18T12:54:26Z","timestamp":1705582466000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1097\/MPG.0b013e31823a29a7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,5]]},"references-count":18,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2012,5]]}},"alternative-id":["10.1097\/MPG.0b013e31823a29a7"],"URL":"https:\/\/doi.org\/10.1097\/mpg.0b013e31823a29a7","archive":["Portico"],"relation":{},"ISSN":["0277-2116","1536-4801"],"issn-type":[{"value":"0277-2116","type":"print"},{"value":"1536-4801","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,5]]}}}