{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T05:53:06Z","timestamp":1781848386974,"version":"3.54.5"},"reference-count":28,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2012,5,1]],"date-time":"2012-05-01T00:00:00Z","timestamp":1335830400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2012,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objectives:<\/jats:title><jats:p>In the present study, we aimed to assess bone status and the effect of gluten\u2010free diet (GFD) in children with celiac disease (CD), and to evaluate the predictive value of standard serum biochemical indices in the diagnosis of bone mineral density (BMD) disturbances.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p>Forty\u2010five children at the time of diagnosis of CD (group A, 77.8% girls) and 36 children receiving GFD for &gt;2 years (group B, 75% girls) were included. Sixteen children in group A were reexamined 12 months after initiation of GFD. Serum measurements of biochemical bone health indices and BMD, assessed by dual x\u2010ray absorptiometry, were obtained.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>Patients after 1 year of receiving GFD had higher BMD <jats:italic>z<\/jats:italic> scores compared with baseline (\u22121.45 \u00b1 0.28 vs \u22120.61 \u00b1 0.25, respectively, <jats:italic>P<\/jats:italic> = 0.004). BMD <jats:italic>z<\/jats:italic> scores were significantly lower than expected for the normal population, after 1 (<jats:italic>P<\/jats:italic> = 0.03) or at least 2 (<jats:italic>P<\/jats:italic> &lt; 0.001) years of receiving GFD. In group B, BMD <jats:italic>z<\/jats:italic> score was positively correlated with 25\u2010hydroxy vitamin D levels (<jats:italic>P<\/jats:italic> = 0.009). In the repeated measurements group, 25\u2010hydroxy vitamin D differed between pre\u2010 and post\u2010GFD (<jats:italic>P<\/jats:italic> = 0.018). No biochemical index was capable of predicting an abnormal BMD <jats:italic>z<\/jats:italic> score (receiver operating characteristic curve analysis, all of the areas under the curve &lt;0.66).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p>GFD has a beneficial effect on bone health. Two years receiving diet do not ensure normalization. Biochemical markers are not indicative of BMD disturbances. Dual x\u2010ray absorptiometry should be included in the standard management of children with CD.<\/jats:p><\/jats:sec>","DOI":"10.1097\/mpg.0b013e31823f5fc5","type":"journal-article","created":{"date-parts":[[2011,11,18]],"date-time":"2011-11-18T11:01:59Z","timestamp":1321614119000},"page":"680-684","source":"Crossref","is-referenced-by-count":51,"title":["Bone Health in Children With Celiac Disease Assessed By Dual X\u2010ray Absorptiometry"],"prefix":"10.1002","volume":"54","author":[{"given":"Daphne","family":"Margoni","sequence":"first","affiliation":[{"name":"First Department of Paediatrics University of Athens Aghia Sophia Children's Hospital University of Athens Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgos","family":"Chouliaras","sequence":"additional","affiliation":[{"name":"First Department of Paediatrics University of Athens Aghia Sophia Children's Hospital University of Athens Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grigoris","family":"Duscas","sequence":"additional","affiliation":[{"name":"Hygeias Melathron General Hospital University of Athens Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Voskaki","sequence":"additional","affiliation":[{"name":"Institute of Child Health Aghia Sophia Children's Hospital University of Athens Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolaos","family":"Voutsas","sequence":"additional","affiliation":[{"name":"First Department of Paediatrics University of Athens Aghia Sophia Children's Hospital University of Athens Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Papadopoulou","sequence":"additional","affiliation":[{"name":"Third Department of Paediatrics University of Athens Athens 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