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We examined infant weight gain in the second year of life after exposure to high or low levels of mother's milk APN.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p>Breast\u2010feeding mother\u2013infant pairs were recruited in Mexico City and studied for 2 years; 192 infants with at least 12 months' follow\u2010up were analyzed. Monthly milk samples were assayed for APN; mothers were classified as producing high or low levels of milk APN. Infant and maternal serum APN were assessed during year 1. Infant anthropometry was measured monthly (year 1) or bimonthly (year 2), and World Health Organization <jats:italic>z<\/jats:italic> scores were calculated. Longitudinal adjusted models assessed weight\u2010for\u2010age and weight\u2010for\u2010length <jats:italic>z<\/jats:italic> score trajectories from 1 to 2 years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>Maternal serum APN modestly correlated with milk APN (<jats:italic>r<\/jats:italic> = 0.37, <jats:italic>P<\/jats:italic> &lt; 0.0001) and infant serum APN (<jats:italic>r<\/jats:italic> = 0.29, <jats:italic>P<\/jats:italic> = 0.01). Infants exposed to high milk APN experienced increasing weight\u2010for\u2010age and weight\u2010for\u2010length <jats:italic>z<\/jats:italic> scores between age 1 and 2 years in contrast to low milk APN exposure (<jats:italic>P<\/jats:italic> for group \u00d7 time = 0.02 and 0.054, respectively), adjusting for growth in the first 6 months and other covariates. In contrast, infant serum APN in year 1 was not associated with the rate of weight gain in year 2.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p>High human milk APN exposure was associated with accelerated weight trajectory during the second year of life, suggesting its role in catch\u2010up growth after slower weight gain during the first year of life.<\/jats:p><\/jats:sec>","DOI":"10.1097\/mpg.0b013e31823fde04","type":"journal-article","created":{"date-parts":[[2011,11,18]],"date-time":"2011-11-18T11:01:59Z","timestamp":1321614119000},"page":"532-539","source":"Crossref","is-referenced-by-count":73,"title":["Human Milk Adiponectin Affects Infant Weight Trajectory During the Second Year of Life"],"prefix":"10.1002","volume":"54","author":[{"given":"Jessica G.","family":"Woo","sequence":"first","affiliation":[{"name":"Division of Biostatistics and Epidemiology Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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