{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,9]],"date-time":"2026-11-09T20:42:54Z","timestamp":1794256974732,"version":"4.9.0"},"reference-count":34,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2012,5,1]],"date-time":"2012-05-01T00:00:00Z","timestamp":1335830400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2012,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background and Objective:<\/jats:title><jats:p>Accurate data on the optimal chloride (Cl) intake in premature infants are scarce. The aim of the present study was to describe Cl intakes in the first 10 days of life and to assess the relations between high Cl intakes and corrected serum Cl level or markers of severe acidosis in infants &lt;28 weeks' gestation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p>Retrospective cohort study including all of the infants &lt;28 weeks admitted to the neonatal intensive care unit during a 3\u2010year period and cared for from birth until day 10 or more.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>Fifty\u2010six infants were included. Cumulative total Cl intakes reached 9.6 \u00b1 3.7 mmol\/kg at day 3 and 49.2 \u00b1 13.5 mmol\/kg at day 10. Inadvertent intakes (from intravenous fluids other than parenteral nutrition) represented on average 70% of total Cl intakes in the first 3 days. Difference between Cl and sodium intakes reached 7.8 \u00b1 4.8 mmol\/kg at day 10 and mainly originated from parenteral nutrition. By multivariate analysis, cumulative Cl intake &gt;10 mmol\/kg during the first 3 days was an independent risk factor of base excess &lt;\u221210 mmol\/L. Cumulative Cl intake &gt;45 mmol\/kg during the first 10 days was an independent risk factor of corrected chloremia &gt;115 mmol\/L and of base excess &lt;\u221210 mmol\/L.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p>Cumulative Cl intake &gt;10 mmol\/kg during the first 3 days (ie, 3.3 mmol \u00b7 kg<jats:sup>\u22121<\/jats:sup> \u00b7 day<jats:sup>\u22121<\/jats:sup> on average) and &gt;45 mmol\/kg during the first 10 days (ie, 4.5 mmol \u00b7 kg<jats:sup>\u22121<\/jats:sup> \u00b7 day<jats:sup>\u22121<\/jats:sup> on average) may have unwanted metabolic consequences and should be avoided. Imbalance between electrolytes provided by the parenteral nutrition solution need to be detected and corrected.<\/jats:p><\/jats:sec>","DOI":"10.1097\/mpg.0b013e318245b428","type":"journal-article","created":{"date-parts":[[2011,12,15]],"date-time":"2011-12-15T11:36:53Z","timestamp":1323949013000},"page":"613-619","source":"Crossref","is-referenced-by-count":24,"title":["Early Chloride Intake Does Not Parallel That of Sodium in Extremely\u2010Low\u2010Birth\u2010Weight Infants and May Impair Neonatal Outcomes"],"prefix":"10.1002","volume":"54","author":[{"given":"Elsa","family":"Kermorvant\u2010Duchemin","sequence":"first","affiliation":[{"name":"AP\u2010HP Department of Neonatology Necker\u2010Saint\u2010Vincent de Paul Hospital, Paris Paris Descartes University Paris"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Iacobelli","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Neonatal Intensive Care Unit Dijon University Hospital Dijon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"Eleni\u2010Dit\u2010Trolli","sequence":"additional","affiliation":[{"name":"AP\u2010HP Department of Neonatology Necker\u2010Saint\u2010Vincent de Paul Hospital, Paris Paris Descartes University Paris"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Bonsante","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Neonatal Intensive Care Unit Dijon University Hospital Dijon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Kermorvant","sequence":"additional","affiliation":[{"name":"AP\u2010HP Department of Neonatology Necker\u2010Saint\u2010Vincent de Paul Hospital, Paris Paris Descartes University Paris"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilles","family":"Sarfati","sequence":"additional","affiliation":[{"name":"AP\u2010HP Department of Biochemistry Groupe Hospitalier Cochin\u2010Saint\u2010Vincent de Paul Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Bernard","family":"Gouyon","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Neonatal Intensive Care Unit Dijon University Hospital Dijon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"Lapillonne","sequence":"additional","affiliation":[{"name":"AP\u2010HP Department of Neonatology Necker\u2010Saint\u2010Vincent de Paul Hospital, Paris Paris Descartes University Paris"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,5]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mpg.0000181841.07090.f4"},{"key":"e_1_2_8_3_1","first-page":"679","volume-title":"Fanaroff and Martin's Neonatal\u2010Perinatal Medicine: Diseases of the Fetus and Infant","author":"Pointdexter B","year":"2006"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199905000-00007"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005373-200107000-00033"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.83.6.514"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.56.6.425"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.57.6.410"},{"key":"e_1_2_8_9_1","doi-asserted-by":"crossref","unstructured":"LawnCJ WeirFJ McGuireW. 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