{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T13:33:12Z","timestamp":1773408792433,"version":"3.50.1"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,7,1]],"date-time":"2012-07-01T00:00:00Z","timestamp":1341100800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2012,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objectives:<\/jats:title><jats:p>The aim of the study was to analyze the diagnostic performance of anti\u2010deamidated gliadin peptide (dGp) immunoglobulin (Ig) G and IgA regarding the age at celiac disease (CD) diagnosis and the anti\u2010dGp IgG usefulness for diagnosing CD IgA\u2010deficient patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p>Anti\u2010dGp IgG and IgA and anti\u2010native gliadin (nGlia) IgA were determined by enzyme fluoroimmunoassay in 100 newly diagnosed anti\u2010tissue transglutaminase (tTG) IgA\u2010positive pediatric and adult patients with CD and in 100 age\u2010matched patients with other digestive pathologies. Anti\u2010dGp IgG was evaluated in 6 CD IgA\u2010deficient patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>When analyzing all of the patients, the anti\u2010dGp IgG assay showed higher diagnostic accuracy (area under receiver operating characteristic curve), specificity, and positive predictive value than anti\u2010dGp IgA and anti\u2010nGlia IgA. All of the diagnostic parameters corresponding to anti\u2010dGp IgG reached the same values as anti\u2010tTG IgA in children 7 years or younger. In older patients, both anti\u2010dGp isotypes showed an inverse behavior, IgG having a higher specificity and positive predictive value but a lower sensitivity and negative predictive value than IgA. Anti\u2010dGp levels were associated with the severity of intestinal lesions, and an inverse association was found regarding age at diagnosis. Both anti\u2010dGp IgG and IgA were found to be positive in the 9 patients with minimal intestinal changes included in the study. All of the patients with CD with IgA deficiency were positive for anti\u2010dGp IgG.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p>The diagnostic performance of anti\u2010dGp depends on the antibody isotype and on the age at CD diagnosis, anti\u2010dGp IgG being a serological marker at least as useful as anti\u2010tTG IgA for detecting CD in children ages 7 years or younger. Our data also indicate that anti\u2010dGp IgG can improve the diagnosis of IgA\u2010deficient patients.<\/jats:p><\/jats:sec>","DOI":"10.1097\/mpg.0b013e31824703c7","type":"journal-article","created":{"date-parts":[[2011,12,24]],"date-time":"2011-12-24T17:04:21Z","timestamp":1324746261000},"page":"50-55","source":"Crossref","is-referenced-by-count":36,"title":["Diagnostic Value of Anti\u2010deamidated Gliadin Peptide IgG Antibodies for Celiac Disease in Children and IgA\u2010deficient Patients"],"prefix":"10.1002","volume":"55","author":[{"given":"Lourdes","family":"Mozo","sequence":"first","affiliation":[{"name":"Department of Immunology Hospital Universitario Central de Asturias Oviedo Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jes\u00fas","family":"G\u00f3mez","sequence":"additional","affiliation":[{"name":"Department of Immunology Hospital Universitario Central de Asturias Oviedo 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