{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T05:44:39Z","timestamp":1791265479755,"version":"4.1.0"},"reference-count":20,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2012,5,1]],"date-time":"2012-05-01T00:00:00Z","timestamp":1335830400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2012,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective:<\/jats:title><jats:p>The aim of the present study was to examine the effects of early and high intravenous (IV) amino acid (AA) supplementation on growth, health, and neurodevelopment of extremely\u2010low\u2010birth\u2010weight (ELBW) infants throughout their first 2 years of life.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p>Infants were prospectively randomized in a double\u2010masked fashion and treated for 7 days with either IV AA starting at 0.5 g \u00b7 kg<jats:sup>\u22121<\/jats:sup> \u00b7 day<jats:sup>\u22121<\/jats:sup> and increased by 0.5 g \u00b7 kg<jats:sup>\u22121<\/jats:sup> every day to 3 g \u00b7 kg<jats:sup>\u22121<\/jats:sup> \u00b7 day<jats:sup>\u22121<\/jats:sup> or starting at 2 g \u00b7 kg<jats:sup>\u22121<\/jats:sup> \u00b7 day<jats:sup>\u22121<\/jats:sup> of IV AA and advanced by 1 g \u00b7 kg<jats:sup>\u22121<\/jats:sup> every day to 4 g \u00b7 kg<jats:sup>\u22121<\/jats:sup> \u00b7 day<jats:sup>\u22121<\/jats:sup>. Plasma AA concentrations were determined by reverse\u2010phase high\u2010performance liquid chromatography. Survivors were longitudinally assessed with Bayley II Scales of Infant Development and physical, social, and global health.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>Forty\u2010three of 51 survivors were studied. Mental Developmental Index (MDI) and Psychomotor Developmental Index were similar between groups; however, the early and high AA group had a lower MDI at 18 months. This difference disappeared at 2 years of age. The early and high AA group <jats:italic>z<\/jats:italic> score means for weight, length, and head circumferences were significantly lower than the standard AA group at most visits. Cumulative and single plasma AA concentrations correlated negatively with MDI and postnatal growth.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p>ELBW infants who received early and high IV AA during the first week of life were associated with poor overall growth at 2 years.<\/jats:p><\/jats:sec>","DOI":"10.1097\/mpg.0b013e31824887a0","type":"journal-article","created":{"date-parts":[[2012,1,6]],"date-time":"2012-01-06T14:33:36Z","timestamp":1325860416000},"page":"601-607","source":"Crossref","is-referenced-by-count":95,"title":["Impact of Early and High Amino Acid Supplementation on ELBW Infants at 2 Years"],"prefix":"10.1002","volume":"54","author":[{"given":"Cynthia L.","family":"Blanco","sequence":"first","affiliation":[{"name":"Department of Pediatrics University of Texas Health Science Center San Antonio San Antonio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice K.","family":"Gong","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Texas Health Science Center San Antonio San Antonio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Schoolfield","sequence":"additional","affiliation":[{"name":"Department of Academic Technology Services University of Texas Health Science Center San Antonio San Antonio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Belinda K.","family":"Green","sequence":"additional","affiliation":[{"name":"Department of Pharmacy University Health System San Antonio"},{"name":"Pharmacotherapy Division College of Pharmacy University of Texas at Austin San Antonio TX"},{"name":"Pharmacotherapy Education and Research Center University of Texas Health Science Center at San Antonio San Antonio TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanda","family":"Daniels","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Texas Health Science Center San Antonio San Antonio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward A.","family":"Liechty","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Herman B Wells Center for Pediatric Research Indiana University School of Medicine Indianapolis IN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajam","family":"Ramamurthy","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Texas Health Science Center San Antonio San Antonio"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,5]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2005.05.038"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-200301000-00008"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2005.10.038"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/68.5.1128"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1203\/01.pdr.0000214990.86879.26"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2007-0545"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2010.09.082"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2008.04.059"},{"key":"e_1_2_8_10_1","unstructured":"KuczmarskiRJ OgdenCL Grummer\u2010StrawnLM et al. 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