{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T00:03:42Z","timestamp":1780963422379,"version":"3.54.1"},"reference-count":46,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2012,11,1]],"date-time":"2012-11-01T00:00:00Z","timestamp":1351728000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2012,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objectives:<\/jats:title><jats:p>The aim of the study was to investigate the histopathological lesions in the upper gastrointestinal mucosa associated with <jats:italic>Helicobacter pylori<\/jats:italic> infection in children with nonulcer dyspepsia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p>A cross\u2010sectional case\u2010control study was performed on 185 Brazilian children and adolescents (4\u201317 years, mean 9.5 \u00b1 2.7 years), 63.2% girls, submitted to upper gastrointestinal endoscopy. The histopathological lesions of the esophageal and gastric mucosa were analyzed in biopsy samples.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p><jats:italic>H pylori<\/jats:italic> infection was identified in 96 children (51.8%). Moderate to severe chronic active gastritis was present in antrum (70.5%) and corpus (45.2%), with higher grading in antrum than in corpus (<jats:italic>P<\/jats:italic> &lt; 0.05). The topographic distribution of inflammation was pangastritis (61.9%), followed by antral (32.1%) and corpus (5.9%). <jats:italic>H pylori<\/jats:italic> density was higher in antrum than in corpus. Intestinal metaplasia was not found in the <jats:italic>H pylori<\/jats:italic>\u2013infected group, nor was significant gastric atrophy. The scores for esophagitis were significantly higher (<jats:italic>P<\/jats:italic> &lt; 0.05) in the noninfected group (1.4 \u00b1 0.8) than in the <jats:italic>H pylori<\/jats:italic>\u2013infected group (1.07 \u00b1 0.9), with significant negative correlation (<jats:italic>r<\/jats:italic> = 0.29; <jats:italic>P<\/jats:italic> &lt; 0.05) with the scores of gastric inflammation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p>The prevalence of <jats:italic>H pylori<\/jats:italic> infection was high among children with dyspepsia and associated with moderate\/severe degrees of gastric inflammation. The high scores of esophagitis in the noninfected group point to 2 distinct groups of pathological conditions sharing similar clinical patterns.<\/jats:p><\/jats:sec>","DOI":"10.1097\/mpg.0b013e3182618136","type":"journal-article","created":{"date-parts":[[2012,12,17]],"date-time":"2012-12-17T20:01:15Z","timestamp":1355774475000},"page":"523-529","source":"Crossref","is-referenced-by-count":34,"title":["Upper Gastrointestinal Histopathological Findings in Children and Adolescents With Nonulcer Dyspepsia With <i>Helicobacter pylori<\/i> Infection"],"prefix":"10.1002","volume":"55","author":[{"given":"Mary Assis","family":"Carvalho","sequence":"first","affiliation":[{"name":"Division of Pediatric Gastroenterology and Nutrition Department of Pediatrics Botucatu Medical School UNESP Sao Paulo State University Botucatu SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nilton Carlos","family":"Machado","sequence":"additional","affiliation":[{"name":"Division of 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