{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T18:29:48Z","timestamp":1793384988039,"version":"4.5.0"},"reference-count":28,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objectives:<\/jats:title><jats:p>The connections between gut microbiota, energy homeostasis, and inflammation and its role in the pathogenesis of obesity\u2010related disorders are increasingly recognized. We aimed to investigate the effect of the probiotic strain <jats:italic>Lactobacillus salivarius<\/jats:italic> Ls\u201033 on a series of biomarkers related to inflammation and the metabolic syndrome (MS) in adolescents with obesity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p>The study was a double\u2010blind placebo\u2010controlled trial including 50 adolescents with obesity randomized to Ls\u201033 (10<jats:sup>10<\/jats:sup> CFU) or placebo daily for 12 weeks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>The average body mass index\u2010for\u2010age <jats:italic>z<\/jats:italic>\u2010score was 2.6 \u00b1 0.5. There were no differences in biomarkers of inflammation and parameters related to the MS at baseline between the probiotic and placebo groups. Furthermore, there were no differences in changes from baseline to 12\u2010week intervention with regard to any anthropometric measures, blood pressure (systolic and diastolic), fasting glucose and insulin, homeostasis model assessment of insulin resistance, C\u2010peptide, cholesterol, high\u2010density lipoprotein cholesterol, low\u2010density lipoprotein cholesterol, triglyceride, free fatty acids, C\u2010reactive protein, interleukin\u20106, tumor necrosis factor alpha, or fecal calprotectin, despite the increased values of biomarkers of inflammation and of several parameters related to the MS at baseline when compared with normal\u2010weight adolescents. The levels of <jats:italic>L salivarius<\/jats:italic> in fecal samples from the probiotic group in the present study were comparable with the levels reported for the other probiotic lactobacilli and bifidobacteria using quantitative polymerase chain reaction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p>It was not possible to detect any beneficial effect of the probiotic intervention with Ls\u201033 on inflammatory markers or parameters related to the MS in adolescents with obesity being in a state of low\u2010grade systemic inflammation.<\/jats:p><\/jats:sec>","DOI":"10.1097\/mpg.0b013e318263066c","type":"journal-article","created":{"date-parts":[[2012,11,17]],"date-time":"2012-11-17T08:16:28Z","timestamp":1353140188000},"page":"673-678","source":"Crossref","is-referenced-by-count":143,"title":["Probiotics to Adolescents With Obesity"],"prefix":"10.1002","volume":"55","author":[{"given":"Rikke 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