{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T10:00:23Z","timestamp":1776506423568,"version":"3.51.2"},"reference-count":5,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>The updated ESPGHAN guidance on coeliac disease recommends the use of common multiples of the upper limit of normal (ULN) for IgA tissue transglutaminase antibodies (TG2) when deciding which diagnostic pathway to follow. The current lack of standardisation between assays makes it difficult to harmonise results between centres as different performance characteristics are observed with each assay. This variability is shown in data from external quality assessment distributions. As a result, the updated guidance is too generalised for use with all the commercial TG2 kits and is therefore not translatable for use in all centres.<\/jats:p>","DOI":"10.1097\/mpg.0b013e31826531f6","type":"journal-article","created":{"date-parts":[[2012,11,17]],"date-time":"2012-11-17T08:16:28Z","timestamp":1353140188000},"page":"733-735","source":"Crossref","is-referenced-by-count":45,"title":["ESPGHAN Guidance on Coeliac Disease 2012"],"prefix":"10.1002","volume":"55","author":[{"given":"William","family":"Egner","sequence":"first","affiliation":[{"name":"Department of Immunology UK NEQAS for Immunology Immunochemistry &amp; Allergy Sheffield UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Shrimpton","sequence":"additional","affiliation":[{"name":"STHFT Sheffield UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ravishankar","family":"Sargur","sequence":"additional","affiliation":[{"name":"STHFT Sheffield UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dina","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Immunology UK NEQAS for Immunology Immunochemistry &amp; Allergy Sheffield UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kirsty","family":"Swallow","sequence":"additional","affiliation":[{"name":"STHFT Sheffield UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,12]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e31821a23d0"},{"key":"e_1_2_14_3_1","unstructured":"NICE clinical guideline 86: coeliac disease: recognition and assessment of coeliac disease 2009.http:\/\/guidance.nice.org.uk\/CG86\/Guidance. Accessed October 26 2012."},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000171301.35513.cf"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e3182407c6b"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e3182470249"}],"container-title":["Journal of Pediatric Gastroenterology and Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1097\/MPG.0b013e31826531f6","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,18]],"date-time":"2024-01-18T13:28:57Z","timestamp":1705584537000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1097\/MPG.0b013e31826531f6"}},"subtitle":["Multiples of ULN for Decision Making Do Not Harmonise Assay Performance Across Centres"],"short-title":[],"issued":{"date-parts":[[2012,12]]},"references-count":5,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2012,12]]}},"alternative-id":["10.1097\/MPG.0b013e31826531f6"],"URL":"https:\/\/doi.org\/10.1097\/mpg.0b013e31826531f6","archive":["Portico"],"relation":{},"ISSN":["0277-2116","1536-4801"],"issn-type":[{"value":"0277-2116","type":"print"},{"value":"1536-4801","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,12]]}}}