{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T21:57:39Z","timestamp":1790805459059,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2012,11,1]],"date-time":"2012-11-01T00:00:00Z","timestamp":1351728000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000097","name":"National Center for Research Resources","doi-asserted-by":"publisher","award":["5M01 RR00069 [R.J.S.]"],"award-info":[{"award-number":["5M01 RR00069 [R.J.S.]"]}],"id":[{"id":"10.13039\/100000097","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000097","name":"National Center for Research Resources","doi-asserted-by":"publisher","award":["UL1RR025780 [Colorado]"],"award-info":[{"award-number":["UL1RR025780 [Colorado]"]}],"id":[{"id":"10.13039\/100000097","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000097","name":"National Center for Research Resources","doi-asserted-by":"publisher","award":["UL1RR024153 [Pittsburgh]"],"award-info":[{"award-number":["UL1RR024153 [Pittsburgh]"]}],"id":[{"id":"10.13039\/100000097","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000097","name":"National Center for Research Resources","doi-asserted-by":"publisher","award":["UL1RR024134 [Philadelphia]"],"award-info":[{"award-number":["UL1RR024134 [Philadelphia]"]}],"id":[{"id":"10.13039\/100000097","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000097","name":"National Center for Research Resources","doi-asserted-by":"publisher","award":["UL1RR024131 [San Francisco]"],"award-info":[{"award-number":["UL1RR024131 [San Francisco]"]}],"id":[{"id":"10.13039\/100000097","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000097","name":"National Center for Research Resources","doi-asserted-by":"publisher","award":["UL1RR025005 [Baltimore]"],"award-info":[{"award-number":["UL1RR025005 [Baltimore]"]}],"id":[{"id":"10.13039\/100000097","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000097","name":"National Center for Research Resources","doi-asserted-by":"publisher","award":["UL1RR025741 [Chicago]"],"award-info":[{"award-number":["UL1RR025741 [Chicago]"]}],"id":[{"id":"10.13039\/100000097","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000097","name":"National Center for Research Resources","doi-asserted-by":"publisher","award":["UL1RR029877 [New York]"],"award-info":[{"award-number":["UL1RR029877 [New York]"]}],"id":[{"id":"10.13039\/100000097","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2012,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>Biliary atresia (BA) frequently results in portal hypertension (PHT), complications of which lead to significant morbidity and mortality. The Childhood Liver Disease Research and Education Network was used to perform a cross\u2010sectional multicentered analysis of PHT in children with BA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Subjects with BA receiving medical management at a Childhood Liver Disease Research and Education Network site were enrolled. A priori, clinically evident PHT was defined as \u201cdefinite\u201d when there was either history of a complication of PHT or clinical findings consistent with PHT (both splenomegaly and thrombocytopenia). PHT was denoted as \u201cpossible\u201d if one of the findings was present in the absence of a complication, whereas PHT was \u201cabsent\u201d if none of the criteria were met.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>A total of 163 subjects were enrolled between May 2006 and December 2009. At baseline, definite PHT was present in 49%, possible in 17%, and absent in 34% of subjects. Demographics, growth, and anthropometrics were similar amongst the 3 PHT categories. Alanine aminotransferase, \u03b3\u2010glutamyl transpeptidase, and sodium levels were similar, whereas there were significant differences in aspartate aminotransferase (AST), AST\/alanine aminotransferase, albumin, total bilirubin, prothrombin time, white blood cell count, platelet count, and AST\/platelet count between definite and absent PHT. Thirty\u2010four percent of those with definite PHT had either prothrombin time &gt;15 seconds or albumin &lt;3 g\/dL.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Clinically definable PHT is present in two\u2010thirds of North American long\u2010term BA survivors with their native livers. The presence of PHT is associated with measures of hepatic injury and dysfunction, although in this selected cohort, the degree of hepatic dysfunction is relatively mild and growth is preserved.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1097\/mpg.0b013e31826eb0cf","type":"journal-article","created":{"date-parts":[[2012,12,17]],"date-time":"2012-12-17T15:01:15Z","timestamp":1355756475000},"page":"567-573","source":"Crossref","is-referenced-by-count":101,"title":["Portal Hypertension in Children and Young Adults With Biliary Atresia"],"prefix":"10.1002","volume":"55","author":[{"given":"Benjamin L.","family":"Shneider","sequence":"first","affiliation":[{"name":"Children's Hospital Pittsburgh of UPMC Pittsburgh PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bob","family":"Abel","sequence":"additional","affiliation":[{"name":"University of Michigan Ann Arbor MI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Haber","sequence":"additional","affiliation":[{"name":"Children's Hospital of Philadelphia Philadelphia PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saul J.","family":"Karpen","sequence":"additional","affiliation":[{"name":"Texas Children's Hospital Houston TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John C.","family":"Magee","sequence":"additional","affiliation":[{"name":"University of Michigan Ann Arbor MI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rene","family":"Romero","sequence":"additional","affiliation":[{"name":"Emory University Altanta GA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen","family":"Schwarz","sequence":"additional","affiliation":[{"name":"Johns Hopkins University Baltimore MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lee M.","family":"Bass","sequence":"additional","affiliation":[{"name":"Children's Memorial Hospital Chicago IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nanda","family":"Kerkar","sequence":"additional","affiliation":[{"name":"Mount Sinai School of Medicine New York NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander G.","family":"Miethke","sequence":"additional","affiliation":[{"name":"Cincinnati Children's Hospital Medical Center Cincinnati OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Rosenthal","sequence":"additional","affiliation":[{"name":"University of California San Francisco San Francisco CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yumirle","family":"Turmelle","sequence":"additional","affiliation":[{"name":"Washington University St Louis MO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia R.","family":"Robuck","sequence":"additional","affiliation":[{"name":"National Institute of Diabetes and Digestive and Kidney Diseases National Institutes of Health Bethesda MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald J.","family":"Sokol","sequence":"additional","affiliation":[{"name":"University of Colorado and Children's Hospital Colorado Aurora CO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Childhood Liver Disease Research and Education Network (ChiLDREN)","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,11]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.21303"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mpg.0000235754.14488.f9"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(90)90489-N"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3468(97)90611-4"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3468(89)80397-5"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-199111000-00009"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1067\/mpd.2001.115967"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2003.09.019"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20547"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mpg.0000189339.92891.64"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e318189f2d5"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2010.07.004"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2010.04.027"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-94-007-1042-9_19"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3046.2012.01652.x"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e318205993a"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwi188"},{"key":"e_1_2_7_19_1","volume-title":"SAS\/STAT 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