{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T06:18:56Z","timestamp":1773901136281,"version":"3.50.1"},"reference-count":39,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,3,1]],"date-time":"2013-03-01T00:00:00Z","timestamp":1362096000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008264","name":"Kingston General Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008264","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>: Diagnosing eosinophilic esophagitis (EoE) depends on intraepithelial eosinophil count of \u226515 eosinophils per high\u2010power field (HPF); however, differentiating EoE from gastroesophageal reflux disease (GERD) continues to be a challenge because no true \u201ccriterion standard\u201d criteria exist. Identifying clinical and endoscopic characteristics that distinguish EoE could provide a more comprehensive diagnostic strategy than the present criteria. The aim of the study was to determine symptoms and signs that can be used to distinguish EoE from reflux esophagitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p>Adult and pediatric patients with EoE were identified by present diagnostic guidelines including an esophageal biopsy finding of \u226515 eosinophils\/HPF. Patients with GERD were age\u2010matched one to one with patients with EoE. Clinical, endoscopic, and histologic information at the time of diagnosis was obtained from the medical record and compared between pairs by McNemar test. A conditional logistic regression model was created using 6 distinguishing disease characteristics. This model was used to create a nomogram to differentiate EoE from reflux\u2010induced esophagitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>Patients with EoE were 75% men and 68% had a history of atopy. Many aspects of EoE were statistically distinct from GERD when controlling for age. Male sex, dysphagia, history of food impaction, absence of pain\/heartburn, linear furrowing, and white papules were the distinguishing variables used to create the logistic regression model and scoring system based on odds ratios. The area under the curve of the receiver\u2010operator characteristic curve for this model was 0.858.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p>EoE can be distinguished from GERD using a scoring system of clinical and endoscopic features. Prospective studies will be needed to validate this model.<\/jats:p><\/jats:sec>","DOI":"10.1097\/mpg.0b013e3182794466","type":"journal-article","created":{"date-parts":[[2012,11,17]],"date-time":"2012-11-17T08:16:28Z","timestamp":1353140188000},"page":"263-270","source":"Crossref","is-referenced-by-count":34,"title":["Clinical Features Distinguish Eosinophilic and Reflux\u2010induced Esophagitis"],"prefix":"10.1002","volume":"56","author":[{"given":"Daniel J.","family":"Mulder","sequence":"first","affiliation":[{"name":"Department of Anatomy and Cell Biology Queen's University Kingston Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David J.","family":"Hurlbut","sequence":"additional","affiliation":[{"name":"Department of Pathology and Molecular Medicine Queen's University Kingston Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela J.","family":"Noble","sequence":"additional","affiliation":[{"name":"Department of 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