{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T19:22:02Z","timestamp":1779045722840,"version":"3.51.4"},"reference-count":26,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,6,1]],"date-time":"2013-06-01T00:00:00Z","timestamp":1370044800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2013,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objectives:<\/jats:title><jats:p>Celiac disease (CD) is common in patients with autoimmune liver disease (AILD); however, the long\u2010term response to treatment of patients with AILDs coexistent with CD has not been explored in detail. The aim of the present study was to analyze the features and the long\u2010term response to immunosuppressive treatment in children with autoimmune hepatitis (AIH) associated with CD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p>Retrospective and prospective evaluation of patients followed at a single center.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>Among 79 patients with AIH, 15 (19%) had CD (9 type 1, 3 type 2, 3 seronegative). In the group of patients with AIH and CD, female sex was significantly more represented than in the group of patients with AIH alone; also, in the former group, diagnosis was made significantly earlier (<jats:italic>P<\/jats:italic> &lt; 0.05). All of the 15 patients on a gluten\u2010free diet achieved sustained remission when treated with prednisone and azathioprine or cyclosporine. The mean period of follow\u2010up was 73 months; discontinuation of therapy was attempted in 9 patients while in remission: 4 patients relapsed, 5 (33%) could definitively stop immunosuppressive treatment with a mean period of treatment\u2010free sustained remission of 89 months (range 26\u2013174). In the same period, treatment discontinuation, attempted in 24 of 64 patients with AIH without CD, was successful in 5 patients (8%; <jats:italic>P<\/jats:italic> &lt; 0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p>Patients with AIH coexisting with CD achieve treatment\u2010free sustained remission in a significantly higher proportion, when compared with patients with AIH without CD, suggesting a possible long\u2010term adjuvant effect of a gluten\u2010free diet.<\/jats:p><\/jats:sec>","DOI":"10.1097\/mpg.0b013e31828b1dfa","type":"journal-article","created":{"date-parts":[[2013,2,12]],"date-time":"2013-02-12T12:05:55Z","timestamp":1360670755000},"page":"671-674","source":"Crossref","is-referenced-by-count":37,"title":["Celiac Disease\u2013Associated Autoimmune Hepatitis in Childhood"],"prefix":"10.1002","volume":"56","author":[{"given":"Silvia","family":"Nastasio","sequence":"first","affiliation":[{"name":"Department of Clinical and Experimental Medicine Division of Pediatric Gastroenterology University of Pisa Pisa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Sciveres","sequence":"additional","affiliation":[{"name":"Liver Transplantation and Pediatric Hepatology Unit Ismett UPMC Palermo"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia","family":"Riva","sequence":"additional","affiliation":[{"name":"Liver Transplantation and Pediatric Hepatology Unit Ismett UPMC Palermo"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irene P.","family":"Filippeschi","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine Division of Pediatric Gastroenterology University of Pisa Pisa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pietro","family":"Vajro","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery University of Salerno Salerno Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Maggiore","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine Division of Pediatric Gastroenterology University of Pisa Pisa"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,6]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2006.09.034"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2011.04685.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1536-4801.2003.tb08126.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21949"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2005.02328.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2011.04895.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2010.02.006"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2007.12.002"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2008.03.017"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2009.04186.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(99)80297-9"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.65.8.909"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/00042737-199910000-00019"},{"key":"e_1_2_7_15_1","first-page":"53","article-title":"Autoimmune 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