{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T08:17:43Z","timestamp":1776154663530,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,7,1]],"date-time":"2013-07-01T00:00:00Z","timestamp":1372636800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective:<\/jats:title><jats:p>Gastrointestinal disturbances are common in people with cystic fibrosis (CF); however, motility studies in this population have yielded inconsistent results. This study examined gastric emptying (GE) and small bowel transit (SBT) time in children with CF and pancreatic insufficiency compared with a healthy adult reference group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p>Participants consumed an 8\u2010ounce liquid test meal (approximately 550 calories, 32 g of fat) labeled with 300 \u03bcCi 99m technetium (Tc) sulfur colloid. Subjects with CF received a standard dose of pancreatic enzymes before consuming the test meal. GE and SBT were measured using a standard nuclear medicine scan. GE was determined after correcting for 99mTc decay in both anterior and posterior images. SBT was determined by following the movement of the tracer from the stomach to the cecum. The percentage arrival of total small bowel activity at the terminal ileum and cecum\/ascending colon at 6 hours was used as an index of SBT. A 1\u2010way analysis of covariance was performed for comparisons between groups after adjustment for age, sex, and body mass index.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>Subjects with CF (n = 16) had similar GE compared with the healthy reference group (n = 12); however, subjects with CF had significantly prolonged SBT time. At 6 hours, 37.2% \u00b1 25.4% (95% CI 23.7\u201350.7) of the tracer reached the terminal ileum and colon compared with 68.6% \u00b1 13.1% (95% CI 60.2\u201376.9) for the reference group (<jats:italic>P<\/jats:italic> &lt; 0.001). After controlling for sex, age, and body mass index, this difference remained statistically significant (<jats:italic>F<\/jats:italic> = 12.06, adjusted <jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup> = 0.44, <jats:italic>P<\/jats:italic> &lt; 0.002).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p>Children with CF and pancreatic insufficiency had unaltered GE but delayed SBT time when taking pancreatic enzymes.<\/jats:p><\/jats:sec>","DOI":"10.1097\/mpg.0b013e318290d112","type":"journal-article","created":{"date-parts":[[2013,3,22]],"date-time":"2013-03-22T21:39:54Z","timestamp":1363988394000},"page":"81-84","source":"Crossref","is-referenced-by-count":23,"title":["Delayed Small Bowel Transit in Children With Cystic Fibrosis and Pancreatic Insufficiency"],"prefix":"10.1002","volume":"57","author":[{"given":"Alisha J.","family":"Rovner","sequence":"first","affiliation":[{"name":"Division of Gastroenterology, Hepatology and Nutrition The Children's Hospital of Philadelphia Philadelphia PA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joan I.","family":"Schall","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology and Nutrition The Children's Hospital of Philadelphia Philadelphia PA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John T.","family":"Mondick","sequence":"additional","affiliation":[{"name":"Metrum Institute Tariffville CT"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongming","family":"Zhuang","sequence":"additional","affiliation":[{"name":"Department of Radiology The Children's Hospital of Philadelphia Philadelphia PA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria R.","family":"Mascarenhas","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology and Nutrition The Children's Hospital of Philadelphia Philadelphia PA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,7]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"266","volume-title":"Cystic Fibrosis","author":"Mascarenhas M","year":"2010"},{"key":"e_1_2_7_3_1","volume-title":"2009 Annual Data Report","author":"Cystic Fibrosis Foundation Patient Registry.","year":"2010"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-199612000-00001"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2011.04786.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2006.04.013"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(96)70358-X"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1067\/S0022-3476(03)00581-X"},{"key":"e_1_2_7_9_1","first-page":"161","article-title":"Gastric emptying of liquids in cystic fibrosis","volume":"36","author":"Smith H","year":"1990","journal-title":"Acta Univ Carol"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-198012000-00019"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365521.2012.699548"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2010-2460"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-199711000-00002"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.80.2.149"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.287.6398.1011"},{"key":"e_1_2_7_16_1","doi-asserted-by":"crossref","unstructured":"GelfondD MaC SemlerJ BorowitzD. 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