{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,7]],"date-time":"2025-08-07T09:00:30Z","timestamp":1754557230219},"reference-count":34,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,8,1]],"date-time":"2013-08-01T00:00:00Z","timestamp":1375315200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2013,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background and Objectives:<\/jats:title><jats:p>Cholestasis affects 50% of extremely low\u2010birth\u2010weight infants. Its etiology remains poorly understood and the extent of liver injury in these infants is unclear. The premature baboon model provides an opportunity to study neonatal liver disease. We characterize hepatic histopathologic changes in this model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p>Archival tissue and data were obtained from the Southwest Foundation for Biomedical Research Primate Center, San Antonio, TX. Animals were selected based on history of antenatal steroid therapy and absence of sepsis or necrotizing enterocolitis with a protocol duration of at least 21 days and no early death (n = 45). Baboons had been treated per protocol in the neonatal intensive care unit (NICU). At necropsy, liver tissue was harvested and stored. Tissues from fetal gestational controls at similar ages were used for comparison (n = 28). Histologic changes were scored by consensus of 2 pathologists blinded to treatment group. Descriptive and comparative statistics were performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>Control fetal livers had extramedullary hematopoiesis (EMH) that decreased across the gestational range. There was evidence of hepatocyte iron storage and ongoing portal tract development. Livers of NICU\u2010treated baboons had increased Kupffer cell hypertrophy and hemosiderosis. There was a shift away from erythroid EMH toward increased myeloid EMH. There was increased cholestasis, ductular proliferation, portal tract fibrosis, and steatosis in treated animals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p>We found pathologic changes in NICU\u2010treated baboons comparable with findings reported in human infants. The baboon model of prematurity may be a useful tool to explore cholestasis and liver dysfunction in extremely low\u2010birth\u2010weight infants.<\/jats:p><\/jats:sec>","DOI":"10.1097\/mpg.0b013e318293e404","type":"journal-article","created":{"date-parts":[[2013,3,30]],"date-time":"2013-03-30T13:48:31Z","timestamp":1364651311000},"page":"172-179","source":"Crossref","is-referenced-by-count":5,"title":["Liver Disease After Intensive Care of Premature Baboons"],"prefix":"10.1002","volume":"57","author":[{"given":"Jay","family":"Kerecman","sequence":"first","affiliation":[{"name":"Department of Pediatrics F. Edward Hebert School of Medicine Uniformed Services University of the Health Sciences Bethesda MD"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anupamjit","family":"Mehrotra","sequence":"additional","affiliation":[{"name":"Joint Pathology Center Department of Defense Silver Spring MD"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zachary","family":"Goodman","sequence":"additional","affiliation":[{"name":"Department of Pathology and Center for Liver Diseases Inova Fairfax Hospital Falls Church VA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,8]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.64.3.342"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1754.2001.00613.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jp.7211686"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2007.06.002"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jp.7211889"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semperi.2004.09.008"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/014860710202600512"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cld.2007.11.004"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1053\/jpsu.2000.7769"},{"key":"e_1_2_7_11_1","first-page":"167","article-title":"Mental development and growth in children with chronic liver disease of early and late onset","volume":"82","author":"Stewart SM","year":"1988","journal-title":"Pediatrics"},{"key":"e_1_2_7_12_1","first-page":"152","article-title":"Pediatric total parenteral nutrition. Liver histopathology","volume":"105","author":"Cohen C","year":"1981","journal-title":"Arch Pathol Lab Med"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(81)90663-6"},{"key":"e_1_2_7_14_1","first-page":"190","article-title":"Total parenteral nutrition: a histopathologic analysis of the liver changes in 20 children","volume":"7","author":"Mullick FG","year":"1994","journal-title":"Mod Pathol"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2011.07.008"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.63.1.110"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10024-001-0154-7"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.160.4.9810071"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200502-230OC"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.162.5.9912145"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2006-0622"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200309-1276OC"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.5858\/2006-130-1786-MITLOS"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840100105"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840080619"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.earlhumdev.2010.08.012"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00280.2011"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.3945\/jn.110.125799"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/136.10.2547"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20130"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2009-0777"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/pr.2011.33"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00163.2009"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1530\/JOE-12-0070"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1203\/PDR.0b013e3182084f8d"}],"container-title":["Journal of Pediatric Gastroenterology and Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1097\/MPG.0b013e318293e404","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,18]],"date-time":"2024-01-18T12:54:08Z","timestamp":1705582448000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1097\/MPG.0b013e318293e404"}},"subtitle":["Histopathologic Observations"],"short-title":[],"issued":{"date-parts":[[2013,8]]},"references-count":34,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,8]]}},"alternative-id":["10.1097\/MPG.0b013e318293e404"],"URL":"https:\/\/doi.org\/10.1097\/mpg.0b013e318293e404","archive":["Portico"],"relation":{},"ISSN":["0277-2116","1536-4801"],"issn-type":[{"value":"0277-2116","type":"print"},{"value":"1536-4801","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,8]]}}}