{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T17:09:13Z","timestamp":1767892153901,"version":"3.49.0"},"reference-count":31,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,8,1]],"date-time":"2013-08-01T00:00:00Z","timestamp":1375315200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2013,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective:<\/jats:title><jats:p>The aim of the present study was to compare the effect of <jats:italic>Bifidobacterium animalis<\/jats:italic> subspecies <jats:italic>lactis<\/jats:italic> (<jats:italic>B lactis<\/jats:italic>) alone or with 90% galacto\u2010oligosaccharide (GOS) and 10% fructo\u2010oligosaccharide (FOS) on infections in infants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p>In a multicenter trial, healthy, term, newborn infants ages 42 days or younger whose mothers had decided not to breast\u2010feed beyond this age received infant and follow\u2010on formulas containing <jats:italic>B lactis<\/jats:italic> (10<jats:sup>7<\/jats:sup> colony\u2010forming units\/g) + GOS\/FOS (0.4 g\/100 mL, intention\u2010to\u2010treat, n = 261) or <jats:italic>B lactis<\/jats:italic> alone (10<jats:sup>7<\/jats:sup> colony\u2010forming units\/g, intention\u2010to\u2010treat, n = 267). Investigators accessed computer\u2010generated randomization sequences via a remote server. Infants were exclusively fed formulas until 4 to 6 months of age and along with complementary feeding thereafter up to 12 months. The primary outcome was the mean number of annual infections reported by the investigators. Secondary outcomes were mean gains in anthropometric measurements, frequency of antibiotic use, and occurrence of adverse events based on investigators' records at each visit and gastrointestinal tolerance (daily stool frequency and consistency) and volume of formula intake recorded in 6\u2010day diaries by parents.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>Mean \u00b1 standard deviation infection rates in infants followed up to 12 months (full analysis set) were 4.9 \u00b1 3.2 per infant per year in the <jats:italic>B lactis<\/jats:italic> + GOS\/FOS group (n = 219) and 4.5 \u00b1 3.0 per infant per year in the <jats:italic>B lactis<\/jats:italic> group (n = 220; analysis of variance, <jats:italic>P<\/jats:italic> = 0.18). Mean daily weight gain was slightly lower in the <jats:italic>B lactis<\/jats:italic> + GOS\/FOS than the <jats:italic>B lactis<\/jats:italic> group (16.1 \u00b1 2.9 vs 16.6 \u00b1 2.6 g\/day, <jats:italic>P<\/jats:italic> = 0.046), but was not clinically significant. Other outcomes were not significantly different between groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p>Formulas containing <jats:italic>B lactis<\/jats:italic> + GOS\/FOS did not reduce infection rates beyond those containing only <jats:italic>B lactis<\/jats:italic>.<\/jats:p><\/jats:sec>","DOI":"10.1097\/mpg.0b013e318297f35e","type":"journal-article","created":{"date-parts":[[2013,5,1]],"date-time":"2013-05-01T20:51:22Z","timestamp":1367441482000},"page":"180-187","source":"Crossref","is-referenced-by-count":19,"title":["Effect of Infant and Follow\u2010on Formulas Containing <i>B lactis<\/i> and Galacto\u2010 and Fructo\u2010oligosaccharides on Infection in Healthy Term Infants"],"prefix":"10.1002","volume":"57","author":[{"given":"Alain","family":"Bocquet","sequence":"first","affiliation":[{"name":"Universit\u00e9 de Franche\u2010Comt\u00e9 Noisiel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emmanuelle","family":"Lachambre","sequence":"additional","affiliation":[{"name":"Nestl\u00e9 France Noisiel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Kempf","sequence":"additional","affiliation":[{"name":"CK Consulting Strasbourg France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurence","family":"Beck","sequence":"additional","affiliation":[{"name":"Nestl\u00e9 France Noisiel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,8]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00032-09"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1079\/BJN2002563"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.300.6716.11"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2005.074260"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1203\/01.pdr.0000250274.68571.18"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/0115426507022003351"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.02063-08"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anaerobe.2010.02.004"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.02515-05"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0809584105"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-200001000-00019"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1086\/523335"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114510003363"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1536-4801.2004.tb12164.x"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2004-1815"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mcg.0000159217.47419.5b"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(94)91708-6"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-200501000-00007"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mpg.0000221887.28877.c7"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/137.11.2420"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/69.5.1052s"},{"key":"e_1_2_12_23_1","first-page":"1797","article-title":"Infectious risk in day\u2010nursery children","volume":"42","author":"Collet JP","year":"1992","journal-title":"Rev Prat"},{"key":"e_1_2_12_24_1","unstructured":"WHO Multicenter Growth Reference Study Group.WHO child growth standards: length\/height\u2010for\u2010age weight\u2010for\u2010age weight\u2010for\u2010length weight\u2010for\u2010height and body mass index\u2010for\u2010age: methods and development.http:\/\/www.who.int\/childgrowth\/en. 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