{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T02:13:14Z","timestamp":1775787194574,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,9,1]],"date-time":"2013-09-01T00:00:00Z","timestamp":1377993600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2013,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objectives:<\/jats:title><jats:p>Nodular gastritis (NG) associated with <jats:italic>Helicobacter pylori<\/jats:italic> infection can occur commonly in childhood and is regarded to be benign without clinical significance. This study includes endoscopic and histologic analysis of gastric mucosa\u2010associated lymphoid tissue (MALT) to clarify the significance of NG on endoscopy in <jats:italic>H pylori<\/jats:italic>\u2013infected children.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p>Of the 758 children who underwent endoscopy, 80 were identified as having <jats:italic>H pylori<\/jats:italic> infection. These patients were divided into 3 groups based on endoscopic severity of gastric nodularity. Histopathologic grading of MALT and immunohistochemistry of CD3, CD20, cytokeratin, and Ki\u201067 were evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>On endoscopy, severe NG was observed in the antrum of 38 of the 80 subjects, mild NG in 27, and an absence of NG in 15. Density of <jats:italic>H pylori<\/jats:italic> and lymphocyte infiltration differed among the 3 groups (<jats:italic>P<\/jats:italic> = 0.022 and <jats:italic>P<\/jats:italic> = 0.025, respectively). Histological grading for gastric lymphoid infiltrates was compatible with grade 1 in 47 (58.8%), grade 2 in 21 (26.3%), grade 3 in 7 (8.8%), and grade 4\u20135 in 4 (5.1%) in the antrum. Degree of NG, density of <jats:italic>H pylori<\/jats:italic>, neutrophil activity, and gastritis score in the antrum varied with MALT grades (<jats:italic>P<\/jats:italic> = 0.003, <jats:italic>P<\/jats:italic> = 0.042, <jats:italic>P<\/jats:italic> = 0.028, and <jats:italic>P<\/jats:italic> = 0.006, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p>Our study suggests NG may present as a significant gastric manifestation of childhood <jats:italic>H pylori<\/jats:italic> infection that indicates gastric MALT. Thorough histologic investigation may be useful in the evaluation of gastric MALT in children infected with <jats:italic>H pylori<\/jats:italic> that manifests as severe NG in the antrum.<\/jats:p><\/jats:sec>","DOI":"10.1097\/mpg.0b013e318298020a","type":"journal-article","created":{"date-parts":[[2013,5,1]],"date-time":"2013-05-01T20:51:22Z","timestamp":1367441482000},"page":"298-304","source":"Crossref","is-referenced-by-count":21,"title":["Endoscopic and Histologic Analysis of Gastric Mucosa\u2010Associated Lymphoid Tissue in Children With <i>Helicobacter pylori<\/i> Infection"],"prefix":"10.1002","volume":"57","author":[{"given":"Hye Ran","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Pediatrics Seoul National University Bundang Hospital Gyeonggi\u2010do Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyoung Soo","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Seoul National University Bundang Hospital Gyeonggi\u2010do Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin Ho","family":"Paik","sequence":"additional","affiliation":[{"name":"Department of Pathology Seoul National University Bundang Hospital Gyeonggi\u2010do Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hye Seung","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Pathology Seoul National University Bundang Hospital Gyeonggi\u2010do 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