{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T04:45:14Z","timestamp":1763959514087},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,9,1]],"date-time":"2013-09-01T00:00:00Z","timestamp":1377993600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004212","name":"P\u00e4ivikki ja Sakari Sohlbergin S\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004212","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2013,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective:<\/jats:title><jats:p>The aim of this study was to evaluate the suspicion of cow's\u2010milk allergy in infants with unspecific gastrointestinal (GI) symptoms using the double\u2010blind, placebo\u2010controlled food challenge.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p>A prospective cohort study, which recruited 57 consecutive children with gastrointestinally manifested symptoms suspected of cow's\u2010milk allergy. All patients underwent a 5\u2010day double\u2010blind, placebo\u2010controlled food challenge for cow's milk.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>The median age of the patients was 8.7 months. None had measurable cow's\u2010milk\u2013specific IgE. The food challenge was positive in 18 (32%) cases, with symptoms manifesting within 48 hours in 17 of 18 cases. The only symptom that correlated with the positive challenge was loose stools, reported as a presenting symptom in 78% of challenge\u2010positive and in 46% of challenge\u2010negative children (<jats:italic>P<\/jats:italic> = 0.043). During active challenge, the respective proportions were 82% and 2% (<jats:italic>P<\/jats:italic> &lt; 0.0001). No serious adverse effects were manifested during the challenges. In the challenge\u2010negative group, significant placebo reactions occurred in 18 (46%) patients. In the challenge\u2010negative children, adult\u2010type hypolactasia genotype CC frequency was higher (31%, <jats:italic>P<\/jats:italic> = 0.033) than national prevalence of 18%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p>In an infant with unspecific GI symptoms suspected of cow's\u2010milk allergy, this diagnosis is seldom confirmed. Other reasons for the troublesome GI symptoms should also be identified.<\/jats:p><\/jats:sec>","DOI":"10.1097\/mpg.0b013e3182993fe0","type":"journal-article","created":{"date-parts":[[2013,5,2]],"date-time":"2013-05-02T17:28:13Z","timestamp":1367515693000},"page":"281-286","source":"Crossref","is-referenced-by-count":16,"title":["Cow's Milk\u2013Associated Gastrointestinal Symptoms Evaluated Using the Double\u2010Blind, Placebo\u2010Controlled Food Challenge"],"prefix":"10.1002","volume":"57","author":[{"given":"Laura","family":"Merras\u2010Salmio","sequence":"first","affiliation":[{"name":"Division of Pediatric Gastroenterology Children's Hospital Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna S.","family":"Pelkonen","sequence":"additional","affiliation":[{"name":"Department of Allergology Helsinki University Central Hospital Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaija\u2010Leena","family":"Kolho","sequence":"additional","affiliation":[{"name":"Division of Pediatric Gastroenterology Children's Hospital Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikael","family":"Kuitunen","sequence":"additional","affiliation":[{"name":"Department of Allergology Helsinki University Central Hospital Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mika J.","family":"M\u00e4kel\u00e4","sequence":"additional","affiliation":[{"name":"Department of Allergology Helsinki University Central Hospital Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,9]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2012.02808.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.11.044"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.84.5.398"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e3181b7f563"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2011-0204"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(99)70393-3"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.1990.tb00944.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.12.1105"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3038.1999.00022.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3038.2008.00792.x"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7525-4-48"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3038.2009.00929.x"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3038.2006.00455.x"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/1367493509359227"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(05)80689-4"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.16.7.984"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng826"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1398-9995.1999.00134.x"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2003.00437.x"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2007.01430.x"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.10.008"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2005.2324.x"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2005-1069"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.MPG.0000161039.96200.F1"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1067\/mpd.2002.121935"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v13.i8.1230"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2004.040048"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(88)80567-5"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1080\/07853890903121033"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2005.06.018"}],"container-title":["Journal of Pediatric Gastroenterology and Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1097\/MPG.0b013e3182993fe0","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,18]],"date-time":"2024-01-18T13:28:00Z","timestamp":1705584480000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1097\/MPG.0b013e3182993fe0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,9]]},"references-count":30,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013,9]]}},"alternative-id":["10.1097\/MPG.0b013e3182993fe0"],"URL":"https:\/\/doi.org\/10.1097\/mpg.0b013e3182993fe0","archive":["Portico"],"relation":{},"ISSN":["0277-2116","1536-4801"],"issn-type":[{"value":"0277-2116","type":"print"},{"value":"1536-4801","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,9]]}}}