{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,28]],"date-time":"2026-06-28T14:53:59Z","timestamp":1782658439139,"version":"3.54.5"},"reference-count":39,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,9,1]],"date-time":"2013-09-01T00:00:00Z","timestamp":1377993600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000097","name":"National Center for Research Resources","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000097","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["8 UL1 TR000077\u201304"],"award-info":[{"award-number":["8 UL1 TR000077\u201304"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2013,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objectives:<\/jats:title><jats:p>The aim of the present study was to determine the prevalence and predisposing factors for vitamin D deficiency and low bone mineral density (BMD) in patients with intestinal failure (IF).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p>A retrospective review of patients with IF managed at the Cincinnati Children's Hospital Medical Center. IF was defined as history of parenteral nutrition (PN) &gt;30 days. Vitamin D deficiency was defined as serum 25\u2010hydroxyvitamin D (25 (OH) D) &lt;20 ng\/dL. Reduced BMD was defined using dual x\u2010ray absorptiometry <jats:italic>z<\/jats:italic> score \u2264\u20132. A binary logistic regression model was used to test for association of significant risk factors and the outcome variables after univariate analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>One hundred and twenty\u2010three patients with median age of 4 years (range 3\u201322 years) were evaluated. Forty\u2010nine (39.8%) patients had at least a documented serum 25 (OH) D deficiency during the study interval, whereas 10 of 80 patients (12.5%) with dual x\u2010ray absorptiometry scans completed had a low BMD <jats:italic>z<\/jats:italic> score. Age at study entry was associated with both 25 (OH) D deficiency (<jats:italic>P<\/jats:italic> = 0.01) and low BMD <jats:italic>z<\/jats:italic> score (<jats:italic>P<\/jats:italic> = 0.03). Exclusive PN at study entry was associated with reduced bone mass (<jats:italic>P<\/jats:italic> = 0.03). There was no significant association between vitamin D deficiency and low BMD <jats:italic>z<\/jats:italic> score (<jats:italic>P<\/jats:italic> = 0.31).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p>The risk of 25 (OH) D deficiency and low BMD <jats:italic>z<\/jats:italic> score increases with age among patients with IF. Strategies for monitoring and preventing abnormal bone health in older children receiving exclusive PN need to be developed and evaluated.<\/jats:p><\/jats:sec>","DOI":"10.1097\/mpg.0b013e31829c10eb","type":"journal-article","created":{"date-parts":[[2013,5,21]],"date-time":"2013-05-21T17:42:18Z","timestamp":1369158138000},"page":"372-376","source":"Crossref","is-referenced-by-count":44,"title":["Vitamin D Deficiency and Low Bone Mineral Density in Pediatric and Young Adult Intestinal Failure"],"prefix":"10.1002","volume":"57","author":[{"given":"Agozie C.","family":"Ubesie","sequence":"first","affiliation":[{"name":"Division of Gastroenterology, Hepatology and Nutrition Cincinnati Children Hospital Medical Center Cincinnati OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James E.","family":"Heubi","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology and Nutrition Cincinnati Children Hospital Medical Center Cincinnati 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