{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T02:03:16Z","timestamp":1791856996851,"version":"4.3.4"},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,10,1]],"date-time":"2013-10-01T00:00:00Z","timestamp":1380585600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2013,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Aim:<\/jats:title><jats:p>Anti\u2010neutrophil cytoplasmic antibodies (ANCAs) detected by indirect immunofluorescence have been found in patients with inflammatory bowel disease (IBD). Nevertheless, specific antibodies against proteinase\u20103 (PR3) are rare in this context.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p>Sera from 30 consecutive pediatric patients with IBD were evaluated for ANCA\u2010indirect immunofluorescence and its specific antibodies to investigate whether PR3\u2010ANCA positivity (PR3\u2010ANCA+) identifies a distinct IBD subtype.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>The 5 PR3\u2010ANCA+ patients (17%) showed significantly more concomitant biliary disease and severe anal blood loss (<jats:italic>P<\/jats:italic> &lt; 0.05). None had vasculitis features at diagnosis nor during follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p>This pilot study demonstrates significant clinical differences between the PR3\u2010ANCA\u2013positive and \u2013negative IBD subset.<\/jats:p><\/jats:sec>","DOI":"10.1097\/mpg.0b013e31829d4e9e","type":"journal-article","created":{"date-parts":[[2013,6,7]],"date-time":"2013-06-07T11:11:36Z","timestamp":1370603496000},"page":"489-492","source":"Crossref","is-referenced-by-count":10,"title":["C\u2010ANCA\/Proteinase 3\u2013Positive Colitis in Children"],"prefix":"10.1002","volume":"57","author":[{"given":"Stephanie","family":"Van Biervliet","sequence":"first","affiliation":[{"name":"Paediatric Gastroenterology Laboratory of Clinical Biology Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolien","family":"Bonroy","sequence":"additional","affiliation":[{"name":"Department of Clinical Chemistry, Microbiology and 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