{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T17:32:19Z","timestamp":1791912739636,"version":"4.3.4"},"reference-count":24,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,11,1]],"date-time":"2013-11-01T00:00:00Z","timestamp":1383264000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2013,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objectives:<\/jats:title><jats:p>The aim of this study was to investigate whether protozoa can be identified as a cause of recurrent abdominal pain (RAP), and whether protozoan infections can be recognized by a specific clinical presentation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p>For 2 years, all patients (ages 4\u201316 years) fulfilling the Apley criteria of RAP referred to secondary care were prospectively evaluated for protozoa (<jats:italic>Giardia lamblia<\/jats:italic>, <jats:italic>Dientamoeba fragilis<\/jats:italic>, <jats:italic>Blastocystis hominis<\/jats:italic>) and treated if positive. Re\u2010examination followed at least 10 days after treatment. Disappearance of pain with eradication and a pain\u2010free follow\u2010up of at least 6 months were considered to be indicative of a causal relation with RAP. The predictive value of the characteristics of the pain for protozoan infections was calculated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>Of 220 included patients (92 boys, mean age 8.8 years), 215 brought a stool sample; 73 (34%) carried parasites, 10 of whom had 2 parasites, 2 had 3 parasites. Sixty\u2010five patients were treated. Twenty\u2010five (11%) were pain\u2010free after eradication (21 had <jats:italic>D fragilis<\/jats:italic>, 8 <jats:italic>B hominis<\/jats:italic>, 4 <jats:italic>G lamblia<\/jats:italic>), of whom 11 had another infection (2) or constipation (9) as second diagnosis for the pain. Five had recurrence of infection with <jats:italic>D fragilis<\/jats:italic> and were again pain\u2010free with eradication. Patients with protozoa as cause of their pain did not show differences with respect to their presentation when compared with patients with an asymptomatic infection and patients without protozoa.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p>Protozoa were found as the cause of pain in 6% to 11% of children with RAP. These patients did not show a characteristic presentation when compared with patients with other causes of abdominal pain.<\/jats:p><\/jats:sec>","DOI":"10.1097\/mpg.0b013e31829f1bc0","type":"journal-article","created":{"date-parts":[[2013,6,19]],"date-time":"2013-06-19T12:25:55Z","timestamp":1371644755000},"page":"603-606","source":"Crossref","is-referenced-by-count":18,"title":["Protozoa as a Cause of Recurrent Abdominal Pain in Children"],"prefix":"10.1002","volume":"57","author":[{"given":"Carolien F.M.","family":"Gijsbers","sequence":"first","affiliation":[{"name":"Department of Paediatric Gastroenterology Juliana Children's Hospital\/Haga Teaching Hospital The Hague"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joachim J.","family":"Schweizer","sequence":"additional","affiliation":[{"name":"Department of Paediatric Gastroenterology Willem\u2010Alexander Children's Hospital\/Leiden University Medical Centre Leiden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans A.","family":"B\u00fcller","sequence":"additional","affiliation":[{"name":"Sophia Children's Hospital\/Erasmus Medical Centre Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,11]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpara.2006.09.009"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2010.09-0478"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2005.05.011"},{"key":"e_1_2_7_5_1","first-page":"575","article-title":"Dientamoeba fragilis: possibly an important cause of persistent abdominal pain in children","volume":"148","author":"Bosman DK","year":"2004","journal-title":"Ned Tijdschr Geneeskd"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00436-010-1918-7"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2011.02179.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2011.02351.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.33.168.165"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-003-0919-1"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e31823a29a7"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v11.i42.6667"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v12.i12.1941"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2005.72.5.0720501"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1977.26.16"},{"key":"e_1_2_7_16_1","first-page":"A10","article-title":"Eradication of dientamoeba fragilis can resolve IBS\u2010like symptoms","volume":"17","author":"Borody TJ","year":"2002","journal-title":"J Gastroenterol Hepatol"},{"key":"e_1_2_7_17_1","first-page":"634","article-title":"Colitis due to Dientamoeba fragilis","volume":"78","author":"Shein R","year":"1983","journal-title":"Am J Gastroenterol"},{"key":"e_1_2_7_18_1","first-page":"5","article-title":"Intestinal parasites: a study of human appendices","volume":"38","author":"Cerva L","year":"1991","journal-title":"Folia Parasitol (Praha)"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0736-4679(03)00104-5"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-004-1456-0"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.9.4.563"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2003.tb00467.x"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2004.tb02684.x"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.08.063"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(99)00086-8"}],"container-title":["Journal of Pediatric Gastroenterology and Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1097\/MPG.0b013e31829f1bc0","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,29]],"date-time":"2024-01-29T05:01:49Z","timestamp":1706504509000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1097\/MPG.0b013e31829f1bc0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,11]]},"references-count":24,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2013,11]]}},"alternative-id":["10.1097\/MPG.0b013e31829f1bc0"],"URL":"https:\/\/doi.org\/10.1097\/mpg.0b013e31829f1bc0","archive":["Portico"],"relation":{},"ISSN":["0277-2116","1536-4801"],"issn-type":[{"value":"0277-2116","type":"print"},{"value":"1536-4801","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,11]]}}}