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The incidence of IBD in the United States is 70 to 150 cases per 100,000 individuals and, as with other autoimmune diseases, is on the rise. CD can affect any part of the gastrointestinal tract from the mouth to the anus and frequently will include perianal disease. The first description connecting regional enteritis with perianal disease was by Bissell et al in 1934, and since that time perianal disease has become a recognized entity and an important consideration in the diagnosis and treatment of CD. Perianal Crohn disease (PCD) is defined as inflammation at or near the anus, including tags, fissures, fistulae, abscesses, or stenosis. The symptoms of PCD include pain, itching, bleeding, purulent discharge, and incontinence of stool. In this report, we review and discuss the etiology, diagnosis, evaluation, and treatment of PCD.<\/jats:p>","DOI":"10.1097\/mpg.0b013e3182a025ee","type":"journal-article","created":{"date-parts":[[2013,6,25]],"date-time":"2013-06-25T10:19:22Z","timestamp":1372155562000},"page":"401-412","source":"Crossref","is-referenced-by-count":122,"title":["Diagnosis and Treatment of Perianal Crohn Disease"],"prefix":"10.1002","volume":"57","author":[{"given":"Edwin F.","family":"de Zoeten","sequence":"first","affiliation":[{"name":"Department of Pediatrics University of Colorado School of Medicine Children's Hospital Colorado Digestive Health Institute Pediatric Inflammatory Bowel Disease Center Denver CO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brad A.","family":"Pasternak","sequence":"additional","affiliation":[{"name":"Department of Pediatric Gastroenterology Phoenix Children's Hospital Phoenix 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