{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T22:18:49Z","timestamp":1775254729318,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,11,1]],"date-time":"2013-11-01T00:00:00Z","timestamp":1383264000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2013,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective:<\/jats:title><jats:p>Microscopic colitis (MC) is prevalent in adults investigated for chronic watery diarrhea, yet characterization of pediatric MC is limited.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p>Our pathology database was searched from 1995 to 2011 for pediatric cases of lymphocytic colitis (LC) or collagenous colitis (CC). Those with diarrhea persisting for &gt;2 weeks and visually normal colonoscopy were accepted as cases. Demographics, laboratory results, medication use within 3 months of presentation, medical and family history of autoimmune disease, and response to treatment were abstracted.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>A total of 27 cases were histologically consistent with MC on biopsy; 5 with concomitant enteric infection or isolated abdominal pain were excluded. Twenty\u2010two cases of MC (female patients, 59%; median age at diagnosis, 15.3 years) were included (19 LC and 3 CC). Two had type 1 diabetes mellitus, 2 were anti\u2010nuclear antibody positive, and 2 had common variable immunodeficiency. Of 20 patients who underwent an esophagogastroduodenoscopy, 1 had collagenous sprue and 4 had celiac disease. One presented after the clearance of recurrent <jats:italic>Clostridium difficile<\/jats:italic> infection. Previous drug exposures included nonsteroidal anti\u2010inflammatory drugs (n = 7), proton pump inhibitors (n = 6), and selective serotonin reuptake inhibitors (n = 3). Common symptoms in addition to diarrhea included abdominal pain (77.3%) and weight loss (27.3%). Of 17 patients with follow\u2010up, all of the 8 treated with steroids had some response: 57.1% (4\/7) responded to mesalamine and 42.9% (3\/7) responded to bismuth subsalicylate.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p>In this cohort of pediatric patients, LC was much more common than CC. As described in adults, we observed associations with celiac disease, type 1 diabetes mellitus, and medications; we additionally saw an association with immunodeficiency. Our patients showed greater response to steroids than mesalamine or bismuth.<\/jats:p><\/jats:sec>","DOI":"10.1097\/mpg.0b013e3182a1df59","type":"journal-article","created":{"date-parts":[[2013,7,2]],"date-time":"2013-07-02T15:07:18Z","timestamp":1372777638000},"page":"557-561","source":"Crossref","is-referenced-by-count":17,"title":["Clinical Features and Treatment Responses in Pediatric Lymphocytic and Collagenous Colitis"],"prefix":"10.1002","volume":"57","author":[{"given":"Nirmala P.","family":"Narla","sequence":"first","affiliation":[{"name":"Mayo Medical School Rochester MN"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas C.","family":"Smyrk","sequence":"additional","affiliation":[{"name":"Department of Anatomic Pathology and Laboratory Medicine Rochester MN"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Darrell S.","family":"Pardi","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Rochester MN"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeanne","family":"Tung","sequence":"additional","affiliation":[{"name":"Division of Pediatric Gastroenterology and Hepatology Mayo Clinic Rochester MN"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,11]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2011.02.003"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.39.6.846"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2006.105890"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-009-0964-4"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2559.1996.d01-498.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.15.3122"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAP.0b013e31823d7705"},{"key":"e_1_2_7_9_1","first-page":"2126","article-title":"Lymphocytic colitis in a pediatric patient: a possible adverse reaction to carbamazepine","volume":"92","author":"Mahajan L","year":"1997","journal-title":"Am J Gastroenterol"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2008.139"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/00042737-200505000-00015"},{"key":"e_1_2_7_12_1","first-page":"393","article-title":"Lymphocytic colitis in a child with non\u2010responsive celiac disease","volume":"71","author":"Ozturk Y","year":"2008","journal-title":"Acta Gastroenterol Belg"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2002.05595.x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11894-011-0207-7"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2007.00424.x"},{"key":"e_1_2_7_16_1","first-page":"834","article-title":"Juvenile scleroderma and collagenous colitis. 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