{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T15:23:31Z","timestamp":1783351411117,"version":"3.54.6"},"reference-count":46,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective:<\/jats:title><jats:p>The aim was to study the effects of boric acid (BA) and 2\u2010aminoethoxydiphenyl borate (2\u2010APB) on oxidative stress and inflammation in an experimental necrotizing enterocolitis (NEC) rat model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p>Experimental NEC was induced in 40 newborn Sprague\u2010Dawley rats by asphyxia and hypothermia applied in 3 consecutive days. Rats were subdivided into 4 subgroups as NEC, NEC + BA, NEC + 2\u2010APB, and controls. BA and 2\u2010APB were applied daily before the procedure. Serum total antioxidant status, superoxide dismutase (SOD), tumor necrosis factor (TNF)\u2010\u03b1, interleukin (IL)\u20106, and erythrocyte glutathione (GSH) levels were measured. Pathological changes for NEC in intestinal architecture were evaluated by a grading system.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>Pretreatment with BA and 2\u2010APB resulted in a decrease in NEC incidence. In all of the NEC groups, decreased serum levels of GSH and SOD were measured. Boron limited GSH consumption but had no effect on SOD levels. Total antioxidant status levels were not statistically different among groups. In our experimental NEC model, BA, but not 2\u2010APB, prevented the increase of TNF\u2010\u03b1. Pretreatment with BA and 2\u2010APB downregulated the activity levels of IL\u20106 in NEC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p>In the experimental NEC model, BA and 2\u2010APB partly prevent NEC formation, modulate the oxidative stress parameters, bring a significant decrease in GSH consumption, and enhance the antioxidant defense mechanism, but have no effect on total antioxidant status. BA inhibits the hypoxia and hypothermia\u2010induced increase in both IL\u20106 and TNF\u2010a, but 2\u2010APB only in IL\u20106. Boron may be beneficial in preventing NEC.<\/jats:p><\/jats:sec>","DOI":"10.1097\/mpg.0b013e3182a7e02b","type":"journal-article","created":{"date-parts":[[2013,8,13]],"date-time":"2013-08-13T11:48:35Z","timestamp":1376394515000},"page":"61-67","source":"Crossref","is-referenced-by-count":23,"title":["Effects of Boric Acid and 2\u2010Aminoethoxydiphenyl Borate on Necrotizing Enterocolitis"],"prefix":"10.1002","volume":"58","author":[{"given":"Sel\u00e7uk","family":"Yazc","sequence":"first","affiliation":[{"name":"Department of Pediatrics Medical Faculty Bal\u0131kesir University Bal\u0131kesir"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hasan","family":"Ak\u015fit","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Faculty of Veterinary Medicine Bal\u0131kesir University Bal\u0131kesir"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O\u011fuzhan","family":"Korkut","sequence":"additional","affiliation":[{"name":"Department of 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