{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T16:26:51Z","timestamp":1780590411821,"version":"3.54.1"},"reference-count":10,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:p>This retrospective cohort study is primarily aimed to evaluate the outcome of children ages 0 to 18 years old, with acute lymphoblastic leukemia and treated with a modified Berlin-Frankfurt-Muenster\/Hong Kong Acute Lymphoblastic Leukemia (BFM95-HKALL97) protocol at University of Santo Tomas Hospital from January 2005 to December 2009. Seventy-eight patients were included. Majority were between 1 and 10 years old (87.2%), male (61.5%), with normal nutritional status, and classified as upper socioeconomic class (65.3%), mainly from National Capital Region (24.3%). Eighty percent had mild anemia and a white cell count &lt;50,000\/mm<jats:sup>3<\/jats:sup>. No patient had an initial platelet count &lt;20,000\/mm<jats:sup>3<\/jats:sup>. More than 90% were standard risk, with FAB L1 morphology and pre-B immunophenotype. Five-year overall survival (OS) and event-free survival (EFS) rates were 86.94% and 86.2%, respectively. Among the 69 patients in the efficacy subset analysis, the 5-year OS and EFS rates were 98.36% and 86.80%, respectively. Relapse rate was 14.5%. Only FAB morphology and risk classification were correlated with relapse. Most common complications were febrile neutropenia, sepsis, and oral mucositis during induction phase. No deaths occurred due to treatment complications. In conclusion, using higher doses of methotrexate during consolidation phase improved the 5-year OS and EFS rates of our patients, without an increase in complications or deaths. Other contributing factors include improved adherence to treatment and risk-based treatment classification.<\/jats:p>","DOI":"10.1097\/mph.0000000000000751","type":"journal-article","created":{"date-parts":[[2017,1,12]],"date-time":"2017-01-12T17:30:08Z","timestamp":1484242208000},"page":"e116-e123","source":"Crossref","is-referenced-by-count":5,"title":["Survival Outcome of Filipino Children With Acute Lymphoblastic Leukemia Treated With Modified Berlin-Frankfurt-Muenster\/Hong Kong Acute Lymphoblastic Leukemia (BFM95\/HKALL97) Protocol in a Tertiary General Hospital From January 2005 to December 2009: A Retrospective Cohort Study"],"prefix":"10.1097","volume":"39","author":[{"given":"Amanda Christina C.","family":"Dujua","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flerida G.","family":"Hernandez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R2-20230918","doi-asserted-by":"crossref","first-page":"2223","DOI":"10.1038\/sj.leu.2401939","article-title":"Children\u2019s Cancer Group trials in childhood acute lymphoblastic leukemia: 1983-1985","volume":"14","author":"Gaynon","year":"2000","journal-title":"Leukemia"},{"key":"R6-20230918","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1182\/blood-2012-05-378943","article-title":"Pediatric acute lymphoblastic leukemia: where are we going and how do we get there?","volume":"120","author":"Pui","year":"2012","journal-title":"Blood"},{"key":"R7-20230918","first-page":"33","article-title":"Improved outcome of acute lymphoblastic leukemia treated by delayed intensification in Hong Kong Children: HLALL97","volume":"12","author":"Li","year":"2006","journal-title":"Hong Kong Med J"},{"issue":"suppl 1","key":"R9-20230918","article-title":"National comprehensive cancer network task force report: prevention and management of mucositis in cancer care","volume":"6","author":"Besinger","year":"2008","journal-title":"J Natl Compr Canc Netw"},{"key":"R12-20230918","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1038\/sj.leu.2401723","article-title":"Genetic polymorphism of thiopurine methyltransferase and its clinical relevance for childhood acute lymphoblastic leukemia","volume":"14","author":"McLeod","year":"2000","journal-title":"Leukemia"},{"key":"R13-20230918","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1038\/sj.bjc.6605703","article-title":"Geographic and ethnic differences in childhood leukemia and lymphoma survival: comparisons of Philippine residents, Asian Americans and Caucasians in the United States","volume":"103","author":"Redaniel","year":"2010","journal-title":"Br J Cancer"},{"key":"R14-20230918","doi-asserted-by":"crossref","first-page":"4477","DOI":"10.1182\/blood-2007-09-112920","article-title":"Risk-adjusted therapy of acute lymphoblastic leukemia can decrease treatment burden and improve survival: treatment results of 2169 unselected pediatric and adolescents enrolled in the trial ALL-BFM95","volume":"111","author":"Morike","year":"2008","journal-title":"Blood"},{"key":"R15-20230918","doi-asserted-by":"crossref","first-page":"5477","DOI":"10.1182\/blood-2008-01-132837","article-title":"Clinical significance of minimal residual disease in childhood acute lymphoblastic leukemia and its relationship to other prognostic factors: a Children\u2019s Oncology Group study","volume":"111","author":"Borowitz","year":"2008","journal-title":"Blood"},{"key":"R16-20230918","doi-asserted-by":"crossref","first-page":"865979","DOI":"10.1155\/2014\/865979","article-title":"Characterization of pediatric acute lymphoblastic leukemia survival patterns by age at diagnosis","volume":"2014","author":"Hossain","year":"2014","journal-title":"J Cancer Epidemiol"},{"key":"R18-20230918","doi-asserted-by":"crossref","first-page":"3988","DOI":"10.1182\/blood-2014-12-580001","article-title":"Inherited genetic variation in childhood acute lymphoblastic leukemia","volume":"125","author":"Moriyama","year":"2015","journal-title":"Blood"}],"container-title":["Journal of Pediatric Hematology\/Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/00043426-201704000-00019","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,18]],"date-time":"2023-09-18T04:50:49Z","timestamp":1695012649000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/00043426-201704000-00019"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4]]},"references-count":10,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017]]}},"URL":"https:\/\/doi.org\/10.1097\/mph.0000000000000751","relation":{},"ISSN":["1077-4114"],"issn-type":[{"value":"1077-4114","type":"print"}],"subject":[],"published":{"date-parts":[[2017,4]]}}}