{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T18:02:05Z","timestamp":1759341725621,"version":"3.41.0"},"reference-count":9,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:p>Behcet disease is a potentially life-threatening multisystemic vasculitis with thrombotic tendency. Mucocutaneous ulcers, arthritis, and uveitis are the most recognizable features, but may be absent at the time of medical evaluation. We report a case in which a 8-year old patient presented with spontaneous bilateral lower extremity deep venous thromboses, and screening for rheumatologic symptoms led to diagnosing Behcet. This case demonstrates that deep venous thromboses can be the initial event bringing a patient with Behcet to medical attention, highlighting the importance of screening for underlying rheumatologic diseases in pediatric patients who present with unprovoked thrombosis.<\/jats:p>","DOI":"10.1097\/mph.0000000000000830","type":"journal-article","created":{"date-parts":[[2017,4,22]],"date-time":"2017-04-22T18:44:27Z","timestamp":1492886667000},"page":"410-412","source":"Crossref","is-referenced-by-count":6,"title":["Behcet Disease Initially Presenting as Deep Venous Thrombosis: A Case Report"],"prefix":"10.1097","volume":"39","author":[{"given":"Arun","family":"Gurunathan","sequence":"first","affiliation":[{"name":"Division of Oncology"},{"name":"Pediatrics"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"T. Teachey","sequence":"additional","affiliation":[{"name":"Division of Oncology"},{"name":"Pediatrics"},{"name":"Pediatrics"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kudakwashe R.","family":"Chikwava","sequence":"additional","affiliation":[{"name":"Pathology and Laboratory Medicine"},{"name":"Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Char","family":"Witmer","sequence":"additional","affiliation":[{"name":"Pediatrics"},{"name":"Division of Hematology, The Children\u2019s Hospital of Philadelphia"},{"name":"Pediatrics"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ami V.","family":"Desai","sequence":"additional","affiliation":[{"name":"Division of Oncology"},{"name":"Pediatrics"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"R1-20230918","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1097\/BOR.0b013e3283410088","article-title":"Major vessel involvement in Behcet\u2019s disease: an update","volume":"23","author":"Calamia","year":"2011","journal-title":"Curr Opin Rheumatol"},{"key":"R2-20230918","doi-asserted-by":"crossref","first-page":"1723e1","DOI":"10.1016\/j.ajem.2013.07.037","article-title":"Diffuse thrombosis secondary to Behcet\u2019s disease: a case report","volume":"31","author":"Celik","year":"2013","journal-title":"Am J Emerg Med"},{"key":"R3-20230918","doi-asserted-by":"crossref","first-page":"190","DOI":"10.18295\/2075-0528.1571","article-title":"Haemostatic parameters in patients with Behcet\u2019s disease","volume":"2","author":"Alkaabi","year":"2014","journal-title":"Sultan Qaboos Univ Med J"},{"key":"R4-20230918","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1186\/1750-1172-8-81","article-title":"Behcet\u2019s disease: new insight into the relationship between procoagulant state, endothelial activation\/damage and disease activity","volume":"8","author":"Fernandez-Bello","year":"2013","journal-title":"Orphanet J Rare Dis"},{"key":"R5-20230918","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/j.autrev.2012.11.001","article-title":"Association of allelic variants of factor V Leiden, prothrombin and methylenetetrahydrofolate reductase with thrombosis or ocular involvement in Behcet\u2019s disease: a systematic review and meta-analysis","volume":"12","author":"Chamorro","year":"2013","journal-title":"Autoimmun Rev"},{"key":"R6-20230918","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1097\/00005792-200301000-00006","article-title":"The long-term mortality and morbidity of Behcet\u2019s syndrome: a 1-decade outcome survey of 387 patients followed at a dedicated center","volume":"82","author":"Kural-Seyahi","year":"2003","journal-title":"Medicine (Baltimore)"},{"key":"R7-20230918","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1007\/s11926-010-0132-z","article-title":"Behcet\u2019s syndrome","volume":"12","author":"Yazici","year":"2010","journal-title":"Curr Rheumatol Rep"},{"key":"R8-20230918","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1097\/BOR.0b013e32831de4e7","article-title":"Thromboembolic disease in vasculitis","volume":"21","author":"Tomasson","year":"2009","journal-title":"Curr Opin Rheumatol"},{"key":"R9-20230918","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1111\/j.1538-7836.2012.04666.x","article-title":"Autoimmune skin and connective tissue disease and risk of venous thromboembolism: a population-based case-control study","volume":"10","author":"Johannesdottir","year":"2012","journal-title":"J Thromb Haemot"}],"container-title":["Journal of Pediatric Hematology\/Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/00043426-201707000-00018","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T23:47:14Z","timestamp":1750204034000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/00043426-201707000-00018"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7]]},"references-count":9,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2017]]}},"URL":"https:\/\/doi.org\/10.1097\/mph.0000000000000830","relation":{},"ISSN":["1077-4114"],"issn-type":[{"type":"print","value":"1077-4114"}],"subject":[],"published":{"date-parts":[[2017,7]]}}}