{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T22:21:35Z","timestamp":1785363695515,"version":"3.55.0"},"reference-count":42,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:p>The objective of this study was to assess the difference in irritability and perceived expressed emotion (EE) between adolescents with iron deficiency (ID) or iron deficiency anemia (IDA) and their healthy peers. In addition, we aimed to investigate the relationship between hemogram parameters, irritability, and perceived EE in adolescents with ID and IDA. The sample of this single-center cross-sectional case-control study consisted of 89 adolescents from 12 to 17 years of age. Of the participants, 19 had been diagnosed with ID, 31 had IDA, and 39 were healthy controls. Significant differences in the self-reported and parent-reported irritability scores were observed between the ID group and the control group and between the IDA group and the control group. There was also a significant difference in the subscale of irritability between the ID group and the control group. The difference between the IDA and control groups in the intrusiveness subscale was found to be significant as well. Adolescents with IDA and ID exhibited significantly perceived irritability compared with the control group. In terms of irritability, adolescents with IDA and ID revealed greater irritability than their healthy peers. The results of this study suggest that irritability and perceived EE should be investigated in cases of ID, whether with or without anemia. As chronic diseases may benefit substantially from psychiatric consultation, psychosocial evaluation and intervention should be considered a complementary treatment option in the management of ID and IDA.<\/jats:p>","DOI":"10.1097\/mph.0000000000001663","type":"journal-article","created":{"date-parts":[[2019,11,14]],"date-time":"2019-11-14T13:11:09Z","timestamp":1573737069000},"page":"403-409","source":"Crossref","is-referenced-by-count":6,"title":["Irritability and Perceived Expressed Emotion in Adolescents With Iron Deficiency and Iron Deficiency Anemia: A Case-Control Study"],"prefix":"10.1097","volume":"42","author":[{"given":"Halit Necmi","family":"U\u00e7ar","sequence":"first","affiliation":[{"name":"Department of Child and Adolescent Psychiatry, School of Medicine, Sel\u00e7uk University, Konya"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sultan","family":"Aydin K\u00f6ker","sequence":"additional","affiliation":[{"name":"Department of Child Hematology and Oncology, Manisa State Hospital, Manisa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"U\u011fur","family":"Tekin","sequence":"additional","affiliation":[{"name":"Department of Child and Adolescent Psychiatry, Bakirk\u00f6y Dr Sadi Konuk Training and Research Hospital, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2019,11,12]]},"reference":[{"key":"R2-20230918","doi-asserted-by":"crossref","first-page":"2607","DOI":"10.1182\/blood-2012-09-453522","article-title":"Control of iron deficiency anemia in low-and middle-income countries","volume":"121","author":"Pasricha","year":"2013","journal-title":"Blood"},{"key":"R3-20230918","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1093\/jn\/131.2.649S","article-title":"A review of studies on the effect of iron deficiency on cognitive development in children","volume":"131","author":"Grantham-McGregor","year":"2001","journal-title":"J Nutr"},{"key":"R4-20230918","doi-asserted-by":"crossref","first-page":"2534","DOI":"10.1093\/jn\/138.12.2534","article-title":"Why iron deficiency is important in infant development","volume":"138","author":"Beard","year":"2008","journal-title":"J Nutr"},{"key":"R5-20230918","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1507\/endocrj.K07-031","article-title":"Serum levels of ghrelin, leptin, IGF-I, IGFBP-3, insulin, thyroid hormones and cortisol in prepubertal children with iron deficiency","volume":"54","author":"Isguven","year":"2007","journal-title":"Endocr J"},{"key":"R6-20230918","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1159\/000073507","article-title":"Pre-and postweaning iron deficiency alters myelination in Sprague-Dawley rats","volume":"25","author":"Beard","year":"2003","journal-title":"Dev Neurosci"},{"key":"R7-20230918","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1093\/jn\/133.5.1468S","article-title":"Iron deficiency alters brain development and functioning","volume":"133","author":"Beard","year":"2003","journal-title":"J Nutr"},{"key":"R8-20230918","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1080\/10284150500047070","article-title":"Iron deficiency: differential effects on monoamine transporters","volume":"8","author":"Burhans","year":"2005","journal-title":"Nutr Neurosci"},{"key":"R9-20230918","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1016\/j.jpeds.2007.09.048","article-title":"Dose-response relationships between iron deficiency with or without anemia and infant social-emotional behavior","volume":"152","author":"Lozoff","year":"2008","journal-title":"J Pediatr"},{"key":"R10-20230918","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1097\/00004703-200610000-00001","article-title":"Iron deficiency in infancy and mother-child interaction at 5 years","volume":"27","author":"Corapci","year":"2006","journal-title":"J Dev Behav Pediatr"},{"key":"R11-20230918","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1093\/jpepsy\/jsp065","article-title":"Longitudinal evaluation of externalizing and internalizing behavior problems following iron deficiency in infancy","volume":"35","author":"Corapci","year":"2009","journal-title":"J Pediatr Psychol"},{"key":"R12-20230918","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1111\/cdev.12765","article-title":"Associations among infant iron deficiency, childhood emotion and attention regulation, and adolescent problem behaviors","volume":"89","author":"East","year":"2018","journal-title":"Child Dev"},{"key":"R13-20230918","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/S0301-0511(00)00058-2","article-title":"Structural and functional brain development and its relation to cognitive development","volume":"54","author":"Casey","year":"2000","journal-title":"Biol Psychol"},{"key":"R14-20230918","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1111\/j.1467-8624.2012.01857.x","article-title":"A longitudinal study of emotion regulation, emotion lability\u2010negativity, and internalizing symptomatology in maltreated and nonmaltreated children","volume":"84","author":"Kim\u2010Spoon","year":"2013","journal-title":"Child Dev"},{"key":"R15-20230918","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1111\/j.1467-8624.2004.00673.x","article-title":"Emotion regulation as a scientific construct: methodological challenges and directions for child development research","volume":"75","author":"Cole","year":"2004","journal-title":"Child Dev"},{"key":"R16-20230918","first-page":"503","article-title":"The unique contribution of emotional impulsiveness to impairment in major life activities in hyperactive children as adults","volume":"49","author":"Barkley","year":"2010","journal-title":"J Am Acad Child Adolesc Psychiatry"},{"key":"R17-20230918","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1002\/dev.20049","article-title":"Relation of neonatal iron status to individual variability in neonatal temperament","volume":"46","author":"Wachs","year":"2005","journal-title":"Dev Psychobiol"},{"key":"R18-20230918","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1542\/peds.2010-1659","article-title":"Iron-deficiency anemia in infancy and social emotional development in preschool-aged Chinese children","volume":"127","author":"Chang","year":"2011","journal-title":"Pediatrics"},{"key":"R19-20230918","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1179\/147683010X12611460763689","article-title":"Iron deficiency in infancy and neurocognitive functioning at 19 years: evidence of long-term deficits in executive function and recognition memory","volume":"13","author":"Lukowski","year":"2010","journal-title":"Nutr Neurosci"},{"key":"R20-20230918","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S1056-4993(18)30620-5","article-title":"Psychosocial intervention strategies for the depressed child: approaches to treatment and prevention","volume":"1","author":"Asarnow","year":"1992","journal-title":"Child Adolesc Psychiatr Clin N Am"},{"key":"R21-20230918","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1007\/s10578-014-0526-7","article-title":"Parental expressed emotion and youth psychopathology: new directions for an old construct","volume":"46","author":"Peris","year":"2015","journal-title":"Child Psychiatry Hum Dev"},{"key":"R22-20230918","doi-asserted-by":"crossref","first-page":"253","DOI":"10.4274\/jcrpe.3825","article-title":"The relationship between perceived family climate and glycemic control in type 1 diabetes mellitus adolescent Patients","volume":"9","author":"Eray","year":"2017","journal-title":"J Clin Res Pediatr Endocrinol"},{"key":"R23-20230918","first-page":"357","article-title":"Perceived expressed emotion, emotional and behavioral problems and self-esteem in obese adolescents: a case-control study","volume":"10","author":"\u00c7olpan","year":"2018","journal-title":"J Clin Res Pediatr Endocrinol"},{"key":"R24-20230918","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1007\/BF00915083","article-title":"Accelerating stimuli for two classes of coercive behaviors","volume":"5","author":"Patterson","year":"1977","journal-title":"J Abnorm Child Psychol"},{"key":"R25-20230918","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1007\/s00787-015-0772-7","article-title":"Mother and adolescent expressed emotion and adolescent internalizing and externalizing symptom development: a six-year longitudinal study","volume":"25","author":"Hale","year":"2016","journal-title":"Eur Child Adolesc Psychiatry"},{"key":"R26-20230918","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1111\/j.1469-7610.1997.tb01545.x","article-title":"The Strengths and Difficulties Questionnaire: a research note","volume":"38","author":"Goodman","year":"1997","journal-title":"J Child Psychol Psychiatry"},{"key":"R27-20230918","first-page":"65","article-title":"G\u00fc\u00e7ler ve g\u00fc\u00e7l\u00fckler anketi\u2019nin (gga) T\u00fcrk\u00e7e uyarlamasinin psikometrik \u00f6zellikleri [Psychometric properties of the Turkish version of the strengths and difficulties questionnaire]","volume":"15","author":"G\u00fcvenir","year":"2008","journal-title":"Turk J Child Adolesc Ment Health"},{"key":"R28-20230918","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1111\/j.1469-7610.2012.02561.x","article-title":"The Affective Reactivity Index: a concise irritability scale for clinical and research settings","volume":"53","author":"Stringaris","year":"2012","journal-title":"J Child Psychol Psychiatry"},{"key":"R30-20230918","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.adolescence.2010.04.009","article-title":"The level of expressed emotion scale: a useful measure of expressed emotion in adolescents?","volume":"34","author":"Nelis","year":"2011","journal-title":"J Adolesc"},{"key":"R31-20230918","first-page":"191","article-title":"Ergenlerde Kisaltilmis Duygu Disavurum \u00d6l\u00e7egi G\u00fcvenilirlik ve Ge\u00e7erlilik \u00c7alismasi [The reliability and validity study of Shortened Level of Expressed Emotion Scale in adolescents]","volume":"33","author":"Vural","year":"2013","journal-title":"Turk Klin Tip Bilim"},{"key":"R32-20230918","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1037\/a0034891","article-title":"Psychometric properties of the Affective Reactivity Index in Australian adults and adolescents","volume":"26","author":"Mulraney","year":"2014","journal-title":"Psychol Assess"},{"key":"R33-20230918","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1016\/j.neuron.2010.08.040","article-title":"Structural MRI of pediatric brain development: what have we learned and where are we going?","volume":"67","author":"Giedd","year":"2010","journal-title":"Neuron"},{"key":"R34-20230918","first-page":"148","article-title":"Mapping brain maturation","volume":"29","author":"Toga","year":"2006","journal-title":"Focus"},{"key":"R35-20230918","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1186\/1471-244X-13-161","article-title":"Association between psychiatric disorders and iron deficiency anemia among children and adolescents: a nationwide population-based study","volume":"13","author":"Chen","year":"2013","journal-title":"BMC Psychiatry"},{"key":"R36-20230918","doi-asserted-by":"crossref","first-page":"223","DOI":"10.3109\/15622975.2011.570376","article-title":"Brain iron levels in attention-deficit\/hyperactivity disorder: a pilot MRI study","volume":"13","author":"Cortese","year":"2012","journal-title":"World J Biol Psychiatry"},{"key":"R37-20230918","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1007\/s00431-011-1506-6","article-title":"Ferritin and iron levels in children with autistic disorder","volume":"171","author":"Herg\u00fcner","year":"2012","journal-title":"Eur J Pediatr"},{"key":"R38-20230918","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1542\/peds.107.6.1381","article-title":"Iron deficiency and cognitive achievement among school-aged children and adolescents in the United States","volume":"107","author":"Halterman","year":"2001","journal-title":"Pediatrics"},{"key":"R39-20230918","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/j.psychres.2011.03.009","article-title":"Association between serum ferritin concentrations and depressive symptoms in Japanese municipal employees","volume":"189","author":"Yi","year":"2011","journal-title":"Psychiatry Res"},{"key":"R40-20230918","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/S0091-3057(01)00563-9","article-title":"Iron deficiency decreases dopamine D1 and D2 receptors in rat brain","volume":"69","author":"Erikson","year":"2001","journal-title":"Pharmacol Biochem Behav"},{"key":"R41-20230918","doi-asserted-by":"crossref","first-page":"2282","DOI":"10.1093\/jn\/127.12.2282","article-title":"In vivo dopamine metabolism is altered in iron-deficient anemic rats","volume":"127","author":"Nelson","year":"1997","journal-title":"J Nutr"},{"key":"R42-20230918","doi-asserted-by":"crossref","first-page":"2831","DOI":"10.1093\/jn\/130.11.2831","article-title":"Iron deficiency alters dopamine transporter functioning in rat striatum","volume":"130","author":"Erikson","year":"2000","journal-title":"J Nutr"},{"key":"R43-20230918","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1016\/j.jnutbio.2014.07.003","article-title":"Iron and mechanisms of emotional behavior","volume":"25","author":"Kim","year":"2014","journal-title":"J Nutr Biochem"},{"key":"R44-20230918","doi-asserted-by":"crossref","first-page":"1805","DOI":"10.1111\/cdev.12231","article-title":"Beyond stimulus deprivation: iron deficiency and cognitive deficits in postinstitutionalized children","volume":"85","author":"Doom","year":"2014","journal-title":"Child Dev"}],"container-title":["Journal of Pediatric Hematology\/Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/10.1097\/MPH.0000000000001663","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,26]],"date-time":"2024-07-26T22:37:32Z","timestamp":1722033452000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/10.1097\/MPH.0000000000001663"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,12]]},"references-count":42,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020]]}},"URL":"https:\/\/doi.org\/10.1097\/mph.0000000000001663","relation":{},"ISSN":["1077-4114"],"issn-type":[{"value":"1077-4114","type":"print"}],"subject":[],"published":{"date-parts":[[2019,11,12]]}}}