{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T22:26:24Z","timestamp":1767997584748,"version":"3.49.0"},"reference-count":23,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:sec>\n            <jats:title>Objective:<\/jats:title>\n            <jats:p>The aim of this study was to evaluate levels of vitamin D, bone mineral density (BMD), and radiograph features at diagnosis and after 6 months of chemotherapy in patients with acute lymphoblastic leukemia (ALL). Vitamin D levels were also correlated with BMD and radiograph features.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Materials and Methods:<\/jats:title>\n            <jats:p>25-Hydroxy vitamin D [25(OH)D] levels, BMD, and radiograph features were assessed in 50 newly diagnosed patients of ALL in the age group of 2 to 14 years. A total of 30 age-matched and sex-matched children were recruited as controls. Vitamin D deficiency was defined as 25(OH)D &lt;10\u2009ng\/mL, Vitamin D insufficiency as 10 to 29\u2009ng\/mL, and Vitamin D sufficiency as \u226530\u2009ng\/mL. Enzyme immunoassay (EIA) was used for the quantitative measurement of 25(OH)D levels in plasma and a LUNAR DPX NT bone densitometer was used for the assessment of BMD.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>The mean age of the patients was 6.3 years, with a male:female ratio of 1.38:1. The mean 25(OH)D levels were 31.90\u00b116.90\u2009ng\/mL in patients at diagnosis against 41.63\u00b120.50\u2009ng\/mL in controls (<jats:italic toggle=\"yes\">P<\/jats:italic>=0.02). Levels were 18.50\u00b111.10\u2009ng\/mL postchemotherapy (<jats:italic toggle=\"yes\">P<\/jats:italic>=0.00). Female sex was a risk factor for deficient 25(OH)D levels. There was a significant decrease in BMD postchemotherapy in the age groups of 5 to 10 and above 10 years at the femoral neck. Osteopenic changes were observed in more number of patients after 6 months of chemotherapy. There was a significant correlation between vitamin D levels, BMD, and osteopenic changes.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions:<\/jats:title>\n            <jats:p>Vitamin D deficiency was common among ALL patients, which worsened after chemotherapy. This had a significant correlation with BMD and osteopenic changes in radiograph.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1097\/mph.0000000000001908","type":"journal-article","created":{"date-parts":[[2020,8,19]],"date-time":"2020-08-19T20:00:28Z","timestamp":1597867228000},"page":"172-175","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":4,"title":["Bone Mineral Metabolism During Chemotherapy in Childhood Acute Lymphoblastic Leukemia"],"prefix":"10.1097","volume":"43","author":[{"given":"Sonal","family":"Maddheshiya","sequence":"first","affiliation":[{"name":"Pediatrics"},{"name":"Endocrinology"},{"name":"Radiodiagnosis and Imaging, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Surya K.","family":"Singh","sequence":"additional","affiliation":[{"name":"Pediatrics"},{"name":"Endocrinology"},{"name":"Radiodiagnosis and Imaging, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ishan","family":"Kumar","sequence":"additional","affiliation":[{"name":"Pediatrics"},{"name":"Endocrinology"},{"name":"Radiodiagnosis and Imaging, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Priyanka","family":"Aggarwal","sequence":"additional","affiliation":[{"name":"Pediatrics"},{"name":"Endocrinology"},{"name":"Radiodiagnosis and Imaging, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vineeta","family":"Gupta","sequence":"additional","affiliation":[{"name":"Pediatrics"},{"name":"Endocrinology"},{"name":"Radiodiagnosis and Imaging, Institute of Medical Sciences, Banaras Hindu University, Varanasi, 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