{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T18:48:15Z","timestamp":1793645295372,"version":"4.5.1"},"reference-count":20,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:sec>\n            <jats:title>Objectives:<\/jats:title>\n            <jats:p>Drug resistant epilepsy has rarely been reported following posterior reversible encephalopathy syndrome (PRES), with few cases of mesial temporal sclerosis (MTS). The aim of this study was to report clinical and neuroimaging features of MTS subsequent to PRES in hemato-oncologic\/stem cell transplanted children.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Materials and Methods:<\/jats:title>\n            <jats:p>Among 70 children treated in 2 pediatric hemato-oncologic Italian centers between 1994 and 2018 and presenting an episode of PRES, we retrospectively identified and analyzed a subgroup of patients who developed epilepsy and MTS.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>Nine of 70 patients (12.8%) developed post-PRES persistent seizures with magnetic resonance imaging evidence of MTS. One patient died few months after MTS diagnosis, because of hematologic complications; the remaining 8 patients showed unprovoked seizures over time leading to the diagnosis of epilepsy, focal in all and drug resistant in 4. At PRES diagnosis, all patients with further evidence of epilepsy and MTS suffered of convulsive seizures, evolving into status epilepticus in 3. In 3 patients a borderline cognitive level or intellectual disability were diagnosed after the onset of epilepsy, and 2 had behavioral problems impacting their quality of life.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions:<\/jats:title>\n            <jats:p>MTS and long-term focal epilepsy, along with potential cognitive and behavioral disorders, are not uncommon in older pediatric patients following PRES.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1097\/mph.0000000000002139","type":"journal-article","created":{"date-parts":[[2021,3,4]],"date-time":"2021-03-04T11:29:18Z","timestamp":1614857358000},"page":"e168-e175","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Mesial Temporal Sclerosis as Late Consequence of Posterior Reversible Encephalopathy Syndrome in Pediatric Hemato-oncologic Patients"],"prefix":"10.1097","volume":"44","author":[{"given":"Maura","family":"Faraci","sequence":"first","affiliation":[{"name":"Hematopoietic Stem Cell Transplantation Unit, Department of Haemato-Oncology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Nobile","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), University of Genoa, Genoa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lino","family":"Nobili","sequence":"additional","affiliation":[{"name":"Child Neuropsychiatry Unit"},{"name":"Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), University of Genoa, Genoa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riccardo","family":"Masetti","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Pediatric Oncology and Haematology Unit \u201cLalla Ser\u00e0gnoli\u201d"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duccio","family":"Cordelli","sequence":"additional","affiliation":[{"name":"Child Neurology and Psychiatry Unit, St. Orsola-Malpighi Hospital, University of Bologna"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Toni","sequence":"additional","affiliation":[{"name":"Neuroradiology Unit, IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Giardino","sequence":"additional","affiliation":[{"name":"Hematopoietic Stem Cell Transplantation Unit, Department of Haemato-Oncology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Morana","sequence":"additional","affiliation":[{"name":"Neuroradiology Unit, IRCSS Istituto Giannina Gaslini, Genoa, Italy"},{"name":"Department of Neuroscience, University of Turin, Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria M.","family":"Mancardi","sequence":"additional","affiliation":[{"name":"Child Neuropsychiatry Unit"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2021,3,3]]},"reference":[{"key":"R1-20250804","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1016\/S1474-4422(15)00111-8","article-title":"Posterior reversible encephalopathy syndrome: clinical and radiological manifestations, pathophysiology, and outstanding questions","volume":"14","author":"Fugate","year":"2015","journal-title":"Lancet Neurol"},{"key":"R2-20250804","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/j.mehy.2014.02.022","article-title":"Posterior reversible encephalopathy syndrome: the endothelial hypotheses","volume":"82","author":"Marra","year":"2014","journal-title":"Med Hypotheses"},{"key":"R3-20250804","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1038\/bmt.2011.65","article-title":"The role of the endothelium in the short-term complications of hematopoietic SCT","volume":"46","author":"Carreras","year":"2011","journal-title":"Bone Marrow Transplant"},{"key":"R4-20250804","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1097\/NRL.0000000000000103","article-title":"PRES and epilepsy: a potential long-term consequence of a \u201creversible\u201d syndrome","volume":"22","author":"Fitzgerald","year":"2017","journal-title":"Neurologist"},{"key":"R5-20250804","doi-asserted-by":"crossref","first-page":"26","DOI":"10.5414\/NP300771","article-title":"Is posterior reversible encephalopathy syndrome really reversible? 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