{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T21:05:14Z","timestamp":1776978314953,"version":"3.51.4"},"reference-count":5,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:p>Unlike pheochromocytomas, neuroblastomas\u2014which are the most common pediatric extracranial solid tumors\u2014are rarely associated with cardiomyopathy and heart failure due to hypertension. We report the case of a 3-year-old girl with growth failure who had hypertensive cardiomyopathy caused by excessive epinephrine and norepinephrine production from a ganglioneuroblastoma. Circulation improved with alpha-blockers and other medications, which enabled partial tumor resection. Histopathologic analysis confirmed ganglioneuroblastoma. Four courses of James' therapy did not lead to tumor shrinkage; subtotal resection was required, which reduced catecholamine levels. This case underscores the importance of multidisciplinary treatment for hypertensive cardiomyopathy due to excess neuroblastoma-related catecholamines.<\/jats:p>","DOI":"10.1097\/mph.0000000000003192","type":"journal-article","created":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T15:00:10Z","timestamp":1774623610000},"page":"181-184","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Infantile Ganglioneuroblastoma Causing Growth Failure and Hypertensive Cardiomyopathy From Excessive Catecholamine Production"],"prefix":"10.1097","volume":"48","author":[{"given":"Haruka","family":"Shimizu","sequence":"first","affiliation":[{"name":"Department of Pediatric Oncology\/Hematology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuki","family":"Shimizu","sequence":"additional","affiliation":[{"name":"Department of Pediatric Oncology\/Hematology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-9903-8501","authenticated-orcid":false,"given":"Tomohei","family":"Nakao","sequence":"additional","affiliation":[{"name":"Department of Pediatric Oncology\/Hematology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsuhiko","family":"Ohta","sequence":"additional","affiliation":[{"name":"Department of Pediatric Oncology\/Hematology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryuhei","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Pediatric Oncology\/Hematology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keisuke","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kouichi","family":"Toda","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology, Saitama Medical University International Medical Center, Hidaka, Saitama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yujiro","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Fukushima","sequence":"additional","affiliation":[{"name":"Department of Pediatric Oncology\/Hematology"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","published-online":{"date-parts":[[2026,3,20]]},"reference":[{"key":"R2-20260423","doi-asserted-by":"crossref","first-page":"1204851","DOI":"10.3389\/fendo.2023.1204851","article-title":"Pheochromocytoma\/paraganglioma-associated cardiomyopathy","volume":"14","author":"Szatko","year":"2023","journal-title":"Front Endocrinol"},{"key":"R3-20260423","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1001\/jama.1965.03090150015003","article-title":"Combination chemotherapy of childhood neuroblastoma","volume":"194","author":"James","year":"1965","journal-title":"JAMA"},{"key":"R4-20260423","doi-asserted-by":"crossref","first-page":"573","DOI":"10.3233\/NPM-231219","article-title":"Congenital neuroblastoma presenting as profound neonatal metabolic acidosis with systemic hypertension: case report","volume":"16","author":"Morris","year":"2023","journal-title":"J Neonatal Perinatal Med"},{"key":"R5-20260423","doi-asserted-by":"crossref","first-page":"2087","DOI":"10.1007\/s00467-023-06269-2","article-title":"Severe labile hypertension in a patient with catecholamine-secreting neuroblastoma: a case report","volume":"39","author":"Frisby-Zedan","year":"2024","journal-title":"Pediatr Nephrol"},{"key":"R6-20260423","doi-asserted-by":"crossref","first-page":"e30327","DOI":"10.1002\/pbc.30327","article-title":"A male with ganglioneuroblastoma cerebrospinal hemorrhages, cardiomyopathy, and retinopathy due to severe hypertension","volume":"70","author":"Deguchi","year":"2023","journal-title":"Pediatr Blood Cancer"}],"container-title":["Journal of Pediatric Hematology\/Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/10.1097\/MPH.0000000000003192","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T20:00:18Z","timestamp":1776974418000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/10.1097\/MPH.0000000000003192"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,20]]},"references-count":5,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.1097\/mph.0000000000003192","relation":{},"ISSN":["1077-4114","1536-3678"],"issn-type":[{"value":"1077-4114","type":"print"},{"value":"1536-3678","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,20]]},"assertion":[{"value":"2025-04-27","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-30","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}