{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T16:03:15Z","timestamp":1786118595266,"version":"build-2736575974"},"reference-count":39,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,12]]},"DOI":"10.1097\/mph.0b013e31802d3a83","type":"journal-article","created":{"date-parts":[[2006,12,12]],"date-time":"2006-12-12T18:30:29Z","timestamp":1165948229000},"page":"785-790","source":"Crossref","is-referenced-by-count":13,"title":["Thymic Lymphoepitheliomalike Carcinoma in Children: Clinicopathologic Features and Molecular Analysis"],"prefix":"10.1097","volume":"28","author":[{"given":"Chuen","family":"Hsueh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tseng-tong","family":"Kuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ngan-Ming","family":"Tsang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Chin","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao-Ping","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iou-Jih","family":"Hung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-4-20210227","doi-asserted-by":"crossref","first-page":"261","DOI":"10.3109\/08880019209016594","article-title":"Childhood malignant thymoma: clinical, therapeutic, and immunohistochemical considerations","volume":"9","author":"Kaplinsky","year":"1992","journal-title":"Pediatr Hematol Oncol"},{"key":"R2-4-20210227","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1097\/00000478-199105000-00007","article-title":"Primary thymic epithelial neoplasms in children","volume":"15","author":"Cajal","year":"1991","journal-title":"Am J Surg Pathol"},{"key":"R3-4-20210227","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1002\/pbc.20468","article-title":"Thymic carcinoma in children","volume":"47","author":"Yaris","year":"2006","journal-title":"Pediatr Blood Cancer"},{"key":"R4-4-20210227","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1111\/j.1349-7006.1992.tb00075.x","article-title":"Detection of Epstein-Barr virus DNA in a Japanese case of lymphoepithelioma-like thymic carcinoma","volume":"83","author":"Matsuno","year":"1992","journal-title":"Jpn J Cancer Res"},{"key":"R5-4-20210227","first-page":"107","article-title":"EBER-1 expression in thymic carcinoma","volume":"43","author":"Fujii","year":"1993","journal-title":"Acta Pathol Jpn"},{"key":"R6-4-20210227","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1002\/mpo.2950230214","article-title":"Hypertrophic pulmonary osteoarthropathy in a child with thymic carcinoma: an unusual presentation in childhood","volume":"23","author":"Ilhan","year":"1994","journal-title":"Med Pediatr Oncol"},{"key":"R7-4-20210227","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1002\/(SICI)1096-911X(199606)26:6<419::AID-MPO10>3.0.CO;2-6","article-title":"Treatment of pediatric malignant thymoma: long-term remission in a 14-year-old boy with EBV-associated thymic carcinoma by aggressive, combined modality treatment","volume":"26","author":"Niehues","year":"1996","journal-title":"Med Pediatr Oncol"},{"key":"R8-4-20210227","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1097\/00043426-200003000-00016","article-title":"Epstein-Barr virus\u2014positive undifferentiated thymic carcinoma in a 12-year-old white girl","volume":"22","author":"Stephan","year":"2000","journal-title":"J Pediatr Hematol Oncol"},{"key":"R9-4-20210227","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1080\/08880010050211420","article-title":"Thymic carcinoma, systemic lupus erythematosus, and hypertrophic pulmonary osteoarthropathy in an 11-year-old boy: a novel association","volume":"17","author":"Di Cataldo","year":"2000","journal-title":"Pediatr Hematol Oncol"},{"key":"R10-4-20210227","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1056\/NEJM198505163122006","article-title":"Association of Epstein-Barr virus with thymic carcinoma","volume":"312","author":"Leyvraz","year":"1985","journal-title":"N Engl J Med"},{"key":"R11-4-20210227","first-page":"177","article-title":"World Health Organization Classification of Tumors. Pathology and Genetics of Tumors of the Lung, Pleura, Thymus and Heart","author":"Kuo","year":"2004"},{"key":"R12-4-20210227","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1097\/00000478-198210000-00003","article-title":"Primary thymic carcinomas","volume":"6","author":"Wick","year":"1982","journal-title":"Am J Surg Pathol"},{"key":"R13-4-20210227","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1007\/BF00737071","article-title":"Thymoma and thymic carcinoma. Relation of thymoma epithelial cells to the cortical and medullary differentiation of thymus","volume":"407","author":"Marino","year":"1985","journal-title":"Virchows Arch A Pathol Anat Histopathol"},{"key":"R14-4-20210227","doi-asserted-by":"crossref","first-page":"2485","DOI":"10.1002\/1097-0142(19811201)48:11<2485::AID-CNCR2820481123>3.0.CO;2-R","article-title":"Follow-up study of thymoma with special reference to their clinical stages","volume":"48","author":"Masaoka","year":"1981","journal-title":"Cancer"},{"key":"R15-4-20210227","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1093\/ajcp\/103.3.308","article-title":"The role of Epstein-Barr virus in lymphoepithelioma-like carcinomas","volume":"103","author":"Iezzoni","year":"1995","journal-title":"Am J Clin Pathol"},{"key":"R16-4-20210227","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1034\/j.1600-0463.2000.d01-74.x","article-title":"Absence of latent Epstein-Barr virus in thymic epithelial tumors as demonstrated by Epstein-Barr-encoded RNA (EBER) in situ hybridization","volume":"108","author":"Engel","year":"2000","journal-title":"APMIS"},{"key":"R17-4-20210227","first-page":"385","article-title":"Epstein-Barr virus genome in thymoma and thymic lymphoid hyperplasia","volume":"131","author":"McGuire","year":"1988","journal-title":"Am J Pathol"},{"key":"R18-4-20210227","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/0046-8177(93)90031-B","article-title":"Study of Epstein-Barr virus early RNA 1 (EBER1) expression by in situ hybridization in thymic epithelial tumors of Chinese patients in Taiwan","volume":"24","author":"Wu","year":"1993","journal-title":"Hum Pathol"},{"key":"R19-4-20210227","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1002\/path.1141","article-title":"Detection of Epstein-Barr virus genome within thymic epithelial tumours in Taiwanese patients by nested PCR, PCR in situ hybridization, and RNA in situ hybridization","volume":"197","author":"Chen","year":"2002","journal-title":"J Pathol"},{"key":"R20-4-20210227","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1007\/BF02899425","article-title":"Absence of the Epstein-Barr virus genome in the normal thymus, thymic epithelial tumors, thymic lymphoid hyperplasia in a European population","volume":"59","author":"Borisch","year":"1990","journal-title":"Virchows Arch B Cell Pathol Incl Mol Pathol"},{"key":"R21-4-20210227","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1097\/00000478-200005000-00014","article-title":"CD70 expression in thymic carcinoma","volume":"24","author":"Hishima","year":"2000","journal-title":"Am J Surg Pathol"},{"key":"R22-4-20210227","doi-asserted-by":"crossref","first-page":"2850","DOI":"10.1128\/JCM.42.6.2850-2854.2004","article-title":"A case of Epstein-Barr Virus (EBV)-associated thymic carcinoid and investigation of existence of EBV-infected cells in thymus and thymic tumors","volume":"42","author":"Takahashi","year":"2004","journal-title":"J Clin Microbiol"},{"key":"R23-4-20210227","first-page":"2133","article-title":"Epstein-Barr virus induces invasion and metastasis factors","volume":"23","author":"Wakisaka","year":"2003","journal-title":"Anticancer Res"},{"key":"R24-4-20210227","doi-asserted-by":"crossref","first-page":"8826","DOI":"10.1158\/0008-5472.CAN-05-0591","article-title":"Epstein-Barr virus latent membrane protein 1 (CAO) up-regulates VEGF and TGF alpha concomitant with hyperplasia, with subsequent up-regulation of p16 and MMP9","volume":"65","author":"Stevenson","year":"2005","journal-title":"Cancer Res"},{"key":"R25-4-20210227","doi-asserted-by":"crossref","first-page":"6905","DOI":"10.1073\/pnas.121016998","article-title":"Induction of cyclooxygenase-2 by Epstein-Barr virus latent membrane protein 1 is involved in vascular endothelial growth factor production in nasopharyngeal carcinoma cells","volume":"98","author":"Murono","year":"2001","journal-title":"Proc Natl Acad Sci USA"},{"key":"R26-4-20210227","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S0304-3835(01)00733-9","article-title":"The 30-bp deletion variant: a polymorphism of latent membrane protein 1 prevalent in endemic and non-endemic areas of nasopharyngeal carcinomas in China","volume":"176","author":"Zhang","year":"2002","journal-title":"Cancer Lett"},{"key":"R27-4-20210227","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.1002\/ijc.21595","article-title":"High frequency of latent membrane protein-1 30-bp deletion variant with specific single mutations in Epstein-Barr virus-associated nasopharyngeal carcinoma in Moroccan patients","volume":"118","author":"Dardari","year":"2006","journal-title":"Int J Cancer"},{"key":"R28-4-20210227","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1002\/jmv.10282","article-title":"Analyses of Epstein-Barr virus latent membrane protein-1 in Malaysian nasopharyngeal carcinoma: high prevalence of 30-bp deletion, Xho1 polymorphism and evidence of dual infections","volume":"69","author":"Tan","year":"2003","journal-title":"J Med Virol"},{"key":"R29-4-20210227","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1080\/00016480310000593","article-title":"Latent membrane protein-1 oncogene deletions in nasopharyngeal carcinoma in Caucasian patients","volume":"123","author":"Plaza","year":"2003","journal-title":"Acta Otolaryngol"},{"key":"R30-4-20210227","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1002\/jmv.20129","article-title":"Epstein-barr virus (EBV) in healthy carriers: distribution of genotypes and 30 bp deletion in latent membrane protein-1 (LMP-1) oncogene","volume":"73","author":"Correa","year":"2004","journal-title":"J Med Virol"},{"key":"R31-4-20210227","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1086\/517324","article-title":"The 30-bp deletion variant of Epstein-Barr virus-encoded latent membrane protein-1 prevails in acute infectious mononucleosis","volume":"176","author":"Berger","year":"1997","journal-title":"J Infect Dis"},{"key":"R32-4-20210227","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1002\/hed.20057","article-title":"Prevalence of LMP-1 gene in tonsils and non-neoplastic nasopharynxes by nest-polymerase chain reaction in Taiwan","volume":"26","author":"Pai","year":"2004","journal-title":"Head Neck"},{"key":"R33-4-20210227","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1002\/mpo.2950210913","article-title":"Hypertrophic osteoarthropathy in childhood malignancy","volume":"21","author":"Staalman","year":"1993","journal-title":"Med Pediatr Oncol"},{"key":"R34-4-20210227","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1007\/s002470000250","article-title":"Hypertrophic osteoarthropathy in a child with nasopharyngeal carcinoma","volume":"30","author":"Varan","year":"2000","journal-title":"Pediatr Radiol"},{"key":"R35-4-20210227","first-page":"57","article-title":"Vascular endothelial growth factor and hypertrophic osteoarthropathy","volume":"18","author":"Silveira","year":"2000","journal-title":"Clin Exp Rheumatol"},{"key":"R36-4-20210227","first-page":"614","article-title":"Circulating vascular endothelial growth factor concentrations in a case of pulmonary hypertrophic osteoarthropathy correlation with disease activity","volume":"31","author":"Olan","year":"2004","journal-title":"J Rheumatol"},{"key":"R37-4-20210227","first-page":"3485","article-title":"A case of pulmonary adenocarcinoma associated with hypertrophic osteoarthropathy due to vascular endothelial growth factor","volume":"22","author":"Abe","year":"2002","journal-title":"Anticancer Res"},{"key":"R38-4-20210227","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1177\/1534735405282557","article-title":"Expression of vascular endothelial growth factor (VEGF) and VEGF receptors in tumor angiogenesis and malignancies","volume":"4","author":"Pradeep","year":"2005","journal-title":"Integr Cancer Ther"},{"key":"R39-4-20210227","doi-asserted-by":"crossref","first-page":"50081","DOI":"10.1074\/jbc.M201095200","article-title":"Prostaglandin E2 induces hypoxia-inducible factor-1alpha stabilization and nuclear localization in a human prostate cancer cell line","volume":"277","author":"Liu","year":"2002","journal-title":"J Biol Chem"}],"container-title":["Journal of Pediatric Hematology\/Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.1097\/MPH.0b013e31802d3a83","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T16:13:26Z","timestamp":1786032806000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00043426-200612000-00004"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,12]]},"references-count":39,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2006]]}},"URL":"https:\/\/doi.org\/10.1097\/mph.0b013e31802d3a83","relation":{},"ISSN":["1077-4114"],"issn-type":[{"value":"1077-4114","type":"print"}],"subject":[],"published":{"date-parts":[[2006,12]]}}}