{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T22:38:08Z","timestamp":1788043088925,"version":"build-2784847793"},"reference-count":32,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,7]]},"DOI":"10.1097\/mph.0b013e3181a974b3","type":"journal-article","created":{"date-parts":[[2009,6,26]],"date-time":"2009-06-26T07:19:46Z","timestamp":1246000786000},"page":"493-499","source":"Crossref","is-referenced-by-count":10,"title":["P-glycoprotein Activity Predicts Outcome in Childhood Acute Lymphoblastic Leukemia"],"prefix":"10.1097","volume":"31","author":[{"given":"Jacek","family":"Bro\u017cek","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ewa","family":"Bryl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"P\u0142oszy\u0144ska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Balcerska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacek M.","family":"Witkowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-6-20210227","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/0005-2736(76)90160-7","article-title":"A surface glycoprotein modulating drug permeability in Chinese Hamster ovary cell mutants","volume":"455","author":"Juliano","year":"1976","journal-title":"Biochim Biophys Acta"},{"key":"R2-6-20210227","doi-asserted-by":"crossref","first-page":"2394","DOI":"10.1182\/blood.V81.9.2394.2394","article-title":"Expression of the multidrug resistance-associated P-glikoprotein (P-170) in 59 cases of de novo acute lymphoblastic leukemia: prognostic implications","volume":"81","author":"Goasguen","year":"1993","journal-title":"Blood"},{"key":"R3-6-20210227","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1038\/bjc.1994.462","article-title":"P-glycoprotein and glutathione S-transferase pi in childhood acute lymphoblastic leukaemia","volume":"70","author":"Sauerbrey","year":"1994","journal-title":"Br J Cancer"},{"key":"R4-6-20210227","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1182\/blood.V88.1.309.309","article-title":"Correlation of P-glycoprotein expression and function in childhood acute leukemia: a children's cancer group study","volume":"88","author":"Ivy","year":"1996","journal-title":"Blood"},{"key":"R5-6-20210227","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1046\/j.1365-2141.1999.01378.x","article-title":"P-glycoprotein is an independent prognostic factor predicting relapse in childhood acute lymphoblastic leukaemia: results of a 6-year prospective study","volume":"105","author":"Dhooge","year":"1999","journal-title":"Br J Haematol"},{"key":"R6-6-20210227","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1080\/08880010390204007","article-title":"The combined analysis of P-glycoprotein expression and activity predicts outcome in childhood acute lymphoblastic leukemia","volume":"20","author":"De Moerloose","year":"2003","journal-title":"Pediatr Hematol Oncol"},{"key":"R7-6-20210227","first-page":"1201","article-title":"P-glycoprotein 170 expression and function as an adverse independent prognostic factor in childhood acute lymphoblastic leukemia","volume":"12","author":"Casale","year":"2004","journal-title":"Oncol Rep"},{"key":"R8-6-20210227","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1590\/S1516-31802004000400007","article-title":"Multiple drug resistance protein (MDR-1), multidrug resistance-related protein (MRP) and lung resistance protein (LRP) gene expression in childhood acute lymphoblastic leukemia","volume":"122","author":"Valera","year":"2004","journal-title":"Sao Paulo Med J"},{"key":"R9-6-20210227","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1080\/088800101750059837","article-title":"Initial P-glycoprotein expression in childhood acute lymphoblastic leukemia: no evidence of prognostic impact in follow-up","volume":"18","author":"Kanerva","year":"2001","journal-title":"Pediatr Hematol Oncol"},{"key":"R10-6-20210227","first-page":"711","article-title":"Clinical significance of P-glycoprotein expression and function for response to induction chemotherapy, relapse rate and overall survival in acute leukemia","volume":"85","author":"Wuchter","year":"2000","journal-title":"Haematologica"},{"key":"R11-6-20210227","doi-asserted-by":"crossref","first-page":"2092","DOI":"10.1182\/blood.V91.6.2092.2092_2092_2098","article-title":"Relationship between major vault protein\/lung resistance protein, multidrug resistance-associated protein, P-glycoprotein expression, and drug resistance in childhood leukemia","volume":"91","author":"den Boer","year":"1998","journal-title":"Blood"},{"key":"R12-6-20210227","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1080\/10428190500032612","article-title":"The prognostic significance of p-glycoprotein, multidrug resistance-related protein 1 and lung resistance protein in pediatric acute lymphoblastic leukemia: a retrospective study of 295 newly diagnosed patients by the children's oncology group","volume":"46","author":"Olson","year":"2005","journal-title":"Leuk Lymphoma"},{"key":"R13-6-20210227","doi-asserted-by":"crossref","first-page":"2735","DOI":"10.1182\/blood.V80.11.2735.bloodjournal80112735","article-title":"Expression and activity of the multidrug resistance P-glycoprotein in human peripheral blood lymphocytes","volume":"80","author":"Chaudhary","year":"1992","journal-title":"Blood"},{"key":"R14-6-20210227","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1056\/NEJM199808273390907","article-title":"Acute lymphoblastic leukemia","volume":"339","author":"Pui","year":"1998","journal-title":"N Engl J Med"},{"key":"R15-6-20210227","doi-asserted-by":"crossref","first-page":"3122","DOI":"10.1182\/blood.V84.9.3122.3122","article-title":"Chemotherapy in 998 unselected childhood acute lymphoblastic leukemia patients. Results and conclusions of the multicenter trial ALL-BFM 86","volume":"84","author":"Reiter","year":"1994","journal-title":"Blood"},{"key":"R16-6-20210227","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1200\/JCO.1986.4.5.744","article-title":"Improved disease-free survival of children with acute lymphoblastic leukemia at high risk for early relapse with the New York regimen-a new intensive therapy protocol: a report from the childrens cancer study group","volume":"4","author":"Steinherz","year":"1986","journal-title":"J Clin Oncol"},{"key":"R17-6-20210227","first-page":"968","article-title":"Significantly lower P-glycoprotein expression in acute promyelocytic leukemia than in other types of acute myeloid leukemia: immunological, molecular and functional analyses","volume":"8","author":"Paietta","year":"1994","journal-title":"Leukemia"},{"issue":"1\u20132","key":"R18-6-20210227","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/s002770050307","article-title":"Expression and functional activity of P-glycoprotein in adult acute myelogenous leukemia patients","volume":"75","author":"Nuessler","year":"1997","journal-title":"Ann Hematol"},{"key":"R19-6-20210227","first-page":"350","article-title":"Low frequency of activity of P-glycoprotein (P-170) in acute lymphoblastic leukemia compared to acute myeloid leukemia","volume":"9","author":"Ludescher","year":"1995","journal-title":"Leukemia"},{"key":"R20-6-20210227","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1038\/sj.leu.2400538","article-title":"A novel energy dependent mechanism reducing daunorubicin accumulation in acute myeloid leukemia","volume":"11","author":"Hedley","year":"1997","journal-title":"Leukemia"},{"issue":"1\u20132","key":"R21-6-20210227","first-page":"3","article-title":"Bodipy-FL-verapamil: a fluorescent probe for the study of multidrug resistance proteins","volume":"26","author":"Rosati","year":"2004","journal-title":"Cell Oncol"},{"key":"R22-6-20210227","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1177\/107327480301000207","article-title":"Overcoming multidrug resistance in cancer: an update on the clinical strategy of inhibiting p-glycoprotein","volume":"10","author":"Thomas","year":"2003","journal-title":"Cancer Control"},{"key":"R23-6-20210227","first-page":"1549","article-title":"Multi-drug resistance (MDR) activity in acute leukemia determined by rhodamine 123 efflux assay","volume":"9","author":"Lamy","year":"1995","journal-title":"Leukemia"},{"key":"R24-6-20210227","doi-asserted-by":"crossref","first-page":"2329","DOI":"10.1182\/blood.V86.6.2329.bloodjournal8662329","article-title":"Correlation of multidrug resistance (MDR1) protein expression with functional dye\/drug efflux in acute myeloid leukemia by multiparameter flow cytometry: identification of discordant MDR-\/efflux+ and MDR1+\/efflux- cases","volume":"86","author":"Leith","year":"1995","journal-title":"Blood"},{"key":"R25-6-20210227","first-page":"3010","article-title":"Methods to detect P-glycoprotein-associated multidrug resistance in patients' tumors: consensus recommendations","volume":"56","author":"Beck","year":"1996","journal-title":"Cancer Res"},{"key":"R26-6-20210227","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1073\/pnas.87.1.152","article-title":"Detection of P-glycoprotein isoforms by gene-specific monoclonal antibodies","volume":"87","author":"Georges","year":"1990","journal-title":"Proc Natl Acad Sci USA"},{"key":"R27-6-20210227","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/0268-960X(95)90039-X","article-title":"Modulation of multidrug resistance in de novo adult acute myeloid leukemia: variable efficacy of reverting agents in vitro. Eastern Cooperative Oncology Group","volume":"9","author":"Paietta","year":"1995","journal-title":"Blood Rev"},{"key":"R28-6-20210227","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1200\/JCO.1999.17.3.818","article-title":"Sex differences in prognosis for children with acute lymphoblastic leukemia","volume":"17","author":"Pui","year":"1999","journal-title":"J Clin Oncol"},{"key":"R29-6-20210227","first-page":"2730","article-title":"Philadelphia chromosome-positive (Ph+) childhood acute lymphoblastic leukemia: good initial steroid response allows early prediction of a favorable treatment outcome","volume":"92","author":"Schrappe","year":"1998","journal-title":"Blood"},{"issue":"3\u20134","key":"R30-6-20210227","doi-asserted-by":"crossref","first-page":"187","DOI":"10.3109\/10428199409056282","article-title":"Glucocorticoid resistance in childhood leukemia","volume":"13","author":"Kaspers","year":"1994","journal-title":"Leuk Lymphoma"},{"key":"R31-6-20210227","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1093\/rheumatology\/35.5.430","article-title":"Expression of the multidrug resistance glycoprotein 170 in the peripheral blood lymphocytes of rheumatoid arthritis patients. The percentage of lymphocytes expressing glycoprotein 170 is increased in patients treated with prednisolone","volume":"35","author":"Maillefert","year":"1996","journal-title":"Br J Rheumatol"},{"key":"R32-6-20210227","first-page":"720","article-title":"Chemosensitizing steroids: glucocorticoid receptor agonists capable of inhibiting P-glycoprotein function","volume":"57","author":"Gruol","year":"1997","journal-title":"Cancer Res"}],"container-title":["Journal of Pediatric Hematology\/Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/10.1097\/MPH.0b013e3181a974b3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,14]],"date-time":"2021-05-14T04:05:26Z","timestamp":1620965126000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/00043426-200907000-00006"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,7]]},"references-count":32,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2009]]}},"URL":"https:\/\/doi.org\/10.1097\/mph.0b013e3181a974b3","relation":{},"ISSN":["1077-4114"],"issn-type":[{"value":"1077-4114","type":"print"}],"subject":[],"published":{"date-parts":[[2009,7]]}}}