{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T16:20:07Z","timestamp":1786119607951,"version":"build-2736575974"},"reference-count":45,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,11]]},"DOI":"10.1097\/mph.0b013e3181ed1655","type":"journal-article","created":{"date-parts":[[2010,10,7]],"date-time":"2010-10-07T06:34:49Z","timestamp":1286433289000},"page":"e323-e330","source":"Crossref","is-referenced-by-count":9,"title":["Multiplex Reverse Transcription-Polymerase Chain Reaction as Diagnostic Molecular Screening of 4 Common Fusion Chimeric Genes in Taiwanese Children With Acute Lymphoblastic Leukemia"],"prefix":"10.1097","volume":"32","author":[{"given":"Yung-Li","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu-Rung","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiann-Shiuh","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chih-Cheng","family":"Hsiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai-Hsin","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiunn-Ming","family":"Sheen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao-Neng","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kang-Hsi","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu-Wha","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung-Liang","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsuan-Yu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng-Yao","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsiu-Hao","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ching-Tzu","family":"Yen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing-Fang","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying-Hui","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya-Ping","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chien-Yu","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiann-Tarng","family":"Jou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong-Tsamn","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-19-20210227","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1056\/NEJMra052603","article-title":"Treatment of acute lymphoblastic leukemia","volume":"354","author":"Pui","year":"2006","journal-title":"N Engl J Med"},{"key":"R2-19-20210227","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1016\/S0140-6736(08)60457-2","article-title":"Acute lymphoblastic leukaemia","volume":"371","author":"Pui","year":"2008","journal-title":"Lancet"},{"key":"R3-19-20210227","doi-asserted-by":"crossref","first-page":"6306","DOI":"10.1200\/JCO.2005.05.047","article-title":"Molecular genetics of acute lymphoblastic leukemia","volume":"23","author":"Armstrong","year":"2005","journal-title":"J Clin Oncol"},{"key":"R4-19-20210227","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1056\/NEJMoa033513","article-title":"Gene-expression patterns in drug-resistant acute lymphoblastic leukemia cells and response to treatment","volume":"351","author":"Holleman","year":"2004","journal-title":"N Engl J Med"},{"key":"R5-19-20210227","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1182\/blood-2006-01-0322","article-title":"Genes contributing to minimal residual disease in childhood acute lymphoblastic leukemia: prognostic significance of CASP8AP2","volume":"108","author":"Flotho","year":"2006","journal-title":"Blood"},{"key":"R6-19-20210227","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1182\/blood-2007-01-068478","article-title":"A set of genes that regulate cell proliferation predicts treatment outcome in childhood acute lymphoblastic leukemia","volume":"110","author":"Flotho","year":"2007","journal-title":"Blood"},{"key":"R7-19-20210227","doi-asserted-by":"crossref","first-page":"2951","DOI":"10.1182\/blood-2003-01-0338","article-title":"Classification of pediatric acute lymphoblastic leukemia by gene expression profiling","volume":"102","author":"Ross","year":"2003","journal-title":"Blood"},{"key":"R8-19-20210227","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1182\/blood-2004-04-1552","article-title":"Distinct gene expression profiles determine molecular treatment response in childhood acute lymphoblastic leukemia","volume":"105","author":"Cario","year":"2005","journal-title":"Blood"},{"key":"R9-19-20210227","doi-asserted-by":"crossref","first-page":"4376","DOI":"10.1200\/JCO.2007.14.4519","article-title":"Gene expression signatures predictive of early response and outcome in high-risk childhood acute lymphoblastic leukemia: a Children's Oncology Group Study [corrected]","volume":"26","author":"Bhojwani","year":"2008","journal-title":"J Clin Oncol"},{"key":"R10-19-20210227","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.ccr.2005.03.002","article-title":"Identification of genes associated with chemotherapy crossresistance and treatment response in childhood acute lymphoblastic leukemia","volume":"7","author":"Lugthart","year":"2005","journal-title":"Cancer Cell"},{"key":"R11-19-20210227","first-page":"1985","article-title":"TEL\/AML1 fusion resulting from a cryptic t(12;21) is the most common genetic lesion in pediatric ALL and defines a subgroup of patients with an excellent prognosis","volume":"9","author":"Shurtleff","year":"1995","journal-title":"Leukemia"},{"key":"R12-19-20210227","doi-asserted-by":"crossref","first-page":"1994","DOI":"10.1038\/sj.leu.2401224","article-title":"A multiplex RT-PCR assay for the detection of chimeric transcripts encoded by the risk-stratifying translocations of pediatric acute lymphoblastic leukemia","volume":"12","author":"Scurto","year":"1998","journal-title":"Leukemia"},{"key":"R13-19-20210227","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1002\/mpo.10092","article-title":"Multiplex RT-PCR assay for the detection of major fusion transcripts in Taiwanese children with B-lineage acute lymphoblastic leukemia","volume":"39","author":"Liang","year":"2002","journal-title":"Med Pediatr Oncol"},{"key":"R14-19-20210227","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1038\/leu.2009.248","article-title":"Long-term results of Taiwan Pediatric Oncology Group studies 1997 and 2002 for childhood acute lymphoblastic leukemia","volume":"24","author":"Liang","year":"2010","journal-title":"Leukemia"},{"key":"R15-19-20210227","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/0165-4608(95)00084-4","article-title":"Correlation of cytogenetic results with immunophenotype, genotype, clinical features, and ras mutation in acute myeloid leukemia. A study of 235 Chinese patients in Taiwan","volume":"84","author":"Tien","year":"1995","journal-title":"Cancer Genet Cytogenet"},{"key":"R16-19-20210227","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1038\/leu.2009.250","article-title":"Long-term results of the Italian Association of Pediatric Hematology and Oncology (AIEOP) Studies 82, 87, 88, 91 and 95 for childhood acute lymphoblastic leukemia","volume":"24","author":"Conter","year":"2010","journal-title":"Leukemia"},{"key":"R17-19-20210227","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1038\/leu.2009.257","article-title":"Long-term results of five consecutive trials in childhood acute lymphoblastic leukemia performed by the ALL-BFM study group from 1981 to 2000","volume":"24","author":"Moricke","year":"2010","journal-title":"Leukemia"},{"key":"R18-19-20210227","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1038\/leu.2009.262","article-title":"Long-term results of the children's cancer group studies for childhood acute lymphoblastic leukemia 1983-2002: a Children's Oncology Group Report","volume":"24","author":"Gaynon","year":"2010","journal-title":"Leukemia"},{"key":"R19-19-20210227","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1038\/leu.2009.249","article-title":"Cooperative study group for childhood acute lymphoblastic leukaemia (COALL): long-term results of trials 82, 85, 89, 92 and 97","volume":"24","author":"Escherich","year":"2010","journal-title":"Leukemia"},{"key":"R20-19-20210227","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1038\/leu.2009.255","article-title":"Long-term results of treatment of childhood acute lymphoblastic leukemia in the Czech Republic","volume":"24","author":"Stary","year":"2010","journal-title":"Leukemia"},{"key":"R21-19-20210227","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1038\/leu.2009.258","article-title":"Long-term results of Dutch Childhood Oncology Group studies for children with acute lymphoblastic leukemia from 1984 to 2004","volume":"24","author":"Kamps","year":"2010","journal-title":"Leukemia"},{"key":"R22-19-20210227","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1038\/leu.2009.253","article-title":"Long-term results of Dana-Farber Cancer Institute ALL Consortium protocols for children with newly diagnosed acute lymphoblastic leukemia (1985 to 2000)","volume":"24","author":"Silverman","year":"2010","journal-title":"Leukemia"},{"key":"R23-19-20210227","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1038\/leu.2009.254","article-title":"Long-term results of the Israeli National Studies in childhood acute lymphoblastic leukemia: INS 84, 89 and 98","volume":"24","author":"Stark","year":"2010","journal-title":"Leukemia"},{"key":"R24-19-20210227","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1038\/leu.2009.259","article-title":"Long-term results of the Japanese Childhood Cancer and Leukemia Study Group studies 811, 841, 874 and 911 on childhood acute lymphoblastic leukemia","volume":"24","author":"Tsurusawa","year":"2010","journal-title":"Leukemia"},{"key":"R25-19-20210227","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1038\/leu.2009.251","article-title":"Long-term results of NOPHO ALL-92 and ALL-2000 studies of childhood acute lymphoblastic leukemia","volume":"24","author":"Schmiegelow","year":"2010","journal-title":"Leukemia"},{"key":"R26-19-20210227","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1038\/leu.2009.261","article-title":"Long-term results of the pediatric oncology group studies for childhood acute lymphoblastic leukemia 1984-2001: a report from the Children's Oncology Group","volume":"24","author":"Salzer","year":"2010","journal-title":"Leukemia"},{"key":"R27-19-20210227","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1038\/leu.2009.252","article-title":"Long-term results of St Jude Total Therapy Studies 11, 12, 13A, 13B, and 14 for childhood acute lymphoblastic leukemia","volume":"24","author":"Pui","year":"2010","journal-title":"Leukemia"},{"key":"R28-19-20210227","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1038\/leu.2009.260","article-title":"Long-term results of Tokyo Children's Cancer Study Group trials for childhood acute lymphoblastic leukemia, 1984-1999","volume":"24","author":"Tsuchida","year":"2010","journal-title":"Leukemia"},{"key":"R29-19-20210227","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1038\/leu.2009.256","article-title":"Long-term follow-up of the United Kingdom medical research council protocols for childhood acute lymphoblastic leukaemia, 1980-2001","volume":"24","author":"Mitchell","year":"2010","journal-title":"Leukemia"},{"key":"R30-19-20210227","doi-asserted-by":"crossref","first-page":"2730","DOI":"10.1056\/NEJMoa0900386","article-title":"Treating childhood acute lymphoblastic leukemia without cranial irradiation","volume":"360","author":"Pui","year":"2009","journal-title":"N Engl J Med"},{"key":"R31-19-20210227","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1200\/JCO.1997.15.3.1150","article-title":"TEL gene rearrangement in acute lymphoblastic leukemia: a new genetic marker with prognostic significance","volume":"15","author":"Rubnitz","year":"1997","journal-title":"J Clin Oncol"},{"key":"R32-19-20210227","doi-asserted-by":"crossref","first-page":"4508","DOI":"10.1182\/blood-2005-08-3451","article-title":"Prospective analysis of TEL\/AML1-positive patients treated on Dana-Farber Cancer Institute Consortium Protocol 95-01","volume":"107","author":"Loh","year":"2006","journal-title":"Blood"},{"key":"R33-19-20210227","doi-asserted-by":"crossref","first-page":"2186","DOI":"10.1200\/JCO.2007.14.3552","article-title":"Prospective analysis of TEL gene rearrangements in childhood acute lymphoblastic leukemia: a Children's Oncology Group study","volume":"26","author":"Rubnitz","year":"2008","journal-title":"J Clin Oncol"},{"key":"R34-19-20210227","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1111\/j.1365-2141.2008.06980.x","article-title":"Outcome of ETV6\/RUNX1-positive childhood acute lymphoblastic leukaemia in the NOPHO-ALL-1992 protocol: frequent late relapses but good overall survival","volume":"140","author":"Forestier","year":"2008","journal-title":"Br J Haematol"},{"key":"R35-19-20210227","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1182\/blood.V90.2.571","article-title":"Incidence and clinical relevance of TEL\/AML1 fusion genes in children with acute lymphoblastic leukemia enrolled in the German and Italian multicenter therapy trials. Associazione Italiana Ematologia Oncologia Pediatrica and the Berlin-Frankfurt-Munster Study Group","volume":"90","author":"Borkhardt","year":"1997","journal-title":"Blood"},{"key":"R36-19-20210227","doi-asserted-by":"crossref","first-page":"4933","DOI":"10.1182\/blood.V90.12.4933","article-title":"Incidence of TEL\/AML1 fusion gene analyzed consecutively in children with acute lymphoblastic leukemia in relapse","volume":"90","author":"Harbott","year":"1997","journal-title":"Blood"},{"key":"R37-19-20210227","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1046\/j.1365-2141.2001.02673.x","article-title":"TEL\/AML1 fusion is not a prognostic factor in Dutch childhood acute lymphoblastic leukaemia","volume":"113","author":"Hubeek","year":"2001","journal-title":"Br J Haematol"},{"key":"R38-19-20210227","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1002\/ajh.1159","article-title":"TEL\/AML1 rearrangement and the prognostic significance in childhood acute lymphoblastic leukemia in Hong Kong","volume":"68","author":"Tsang","year":"2001","journal-title":"Am J Hematol"},{"key":"R39-19-20210227","first-page":"991","article-title":"High incidence of TEL\/AML1 fusion resulting from a cryptic t(12;21) in childhood B-lineage acute lymphoblastic leukemia in Taiwan","volume":"10","author":"Liang","year":"1996","journal-title":"Leukemia"},{"key":"R40-19-20210227","first-page":"1463","article-title":"Detection and quantification of TEL\/AML1 fusion transcripts by polymerase chain reaction in childhood acute lymphoblastic leukemia","volume":"10","author":"Nakao","year":"1996","journal-title":"Leukemia"},{"key":"R41-19-20210227","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.cancergencyto.2007.05.019","article-title":"Prevalence of ETV6-RUNX1 fusion gene in children with acute lymphoblastic leukemia in China","volume":"178","author":"Gao","year":"2007","journal-title":"Cancer Genet Cytogenet"},{"key":"R42-19-20210227","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1097\/MPH.0b013e318030ac4c","article-title":"Ethnic differences in the frequency of subtypes of childhood acute lymphoblastic leukemia: results of the Malaysia-Singapore Leukemia Study Group","volume":"29","author":"Ariffin","year":"2007","journal-title":"J Pediatr Hematol Oncol"},{"key":"R43-19-20210227","doi-asserted-by":"crossref","first-page":"5175","DOI":"10.1200\/JCO.2008.21.2514","article-title":"Improved early event-free survival with imatinib in Philadelphia chromosome-positive acute lymphoblastic leukemia: a Children's Oncology Group Study","volume":"27","author":"Schultz","year":"2009","journal-title":"J Clin Oncol"},{"key":"R44-19-20210227","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1182\/blood.V96.1.24","article-title":"Biological and therapeutic aspects of infant leukemia","volume":"96","author":"Biondi","year":"2000","journal-title":"Blood"},{"key":"R45-19-20210227","doi-asserted-by":"crossref","first-page":"984","DOI":"10.3324\/haematol.2008.002436","article-title":"The molecular biology of mixed lineage leukemia","volume":"94","author":"Slany","year":"2009","journal-title":"Haematologica"}],"container-title":["Journal of Pediatric Hematology\/Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.1097\/MPH.0b013e3181ed1655","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T18:38:55Z","timestamp":1786041535000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00043426-201011000-00019"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,11]]},"references-count":45,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2010]]}},"URL":"https:\/\/doi.org\/10.1097\/mph.0b013e3181ed1655","relation":{},"ISSN":["1077-4114"],"issn-type":[{"value":"1077-4114","type":"print"}],"subject":[],"published":{"date-parts":[[2010,11]]}}}