{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T20:35:57Z","timestamp":1775594157823,"version":"3.50.1"},"reference-count":33,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:p>Among the new rehabilitation strategies aimed at improving independent walking after stroke, the body weight-support training allows an early and controlled ambulatory training. To date, most available studies are based on treadmill body weight-support (BWS) training and involve patients with chronic stroke sequelae. In contrast, the effects of a BWS training performed on the ground in patients with subacute hemiparesis (stroke within 4 weeks), with significant gait deficiencies, is unknown. The primary aim of this study was to evaluate the efficacy of a rehabilitative program that combines conventional approach with an early overground body weight-support training, in terms of recovery of independent walking focussing on patients with subacute stroke. The secondary aim was to evaluate the impact of body weight-support also on functional mobility, overall disability, and gait endurance. A total of 37 participants were enrolled and randomized to experimental group or control group for the baseline evaluations. In the experimental group, body weight-supported overground walking was added to conventional physiotherapy for 4 weeks. The outcome measurements used were: Functional Ambulation Classification (FAC), Rivermead Mobility Index, Barthel Index, and the 6-minute Walk Test. At the evaluation 1 week after the end of the intervention period, experimental group reached a statistically significant increase of independent walking as detected by FAC (experimental group: 3 vs. control group: 2, <jats:italic toggle=\"yes\">P<\/jats:italic> &lt; 0.01). No differences were observed by the other evaluation outcome measures. We conclude that BWS training may be more effective than conventional therapy alone in improving walking autonomy in persons with subacute stroke.<\/jats:p>","DOI":"10.1097\/mrr.0000000000000363","type":"journal-article","created":{"date-parts":[[2019,8,17]],"date-time":"2019-08-17T07:49:08Z","timestamp":1566028148000},"page":"309-315","source":"Crossref","is-referenced-by-count":23,"title":["Early body weight-supported overground walking training in patients with stroke in subacute phase compared to conventional physiotherapy: a randomized controlled pilot study"],"prefix":"10.1097","volume":"42","author":[{"given":"Stefano","family":"Brunelli","sequence":"first","affiliation":[{"name":"Fondazione Santa Lucia, Scientific Institute for Research and Healthcare, Operative Unit 4."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Iosa","sequence":"additional","affiliation":[{"name":"Fondazione Santa Lucia, Scientific Institute for Research and Healthcare, Operative Unit 4."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca Romana","family":"Fusco","sequence":"additional","affiliation":[{"name":"Fondazione Santa Lucia, Scientific Institute for Research and Healthcare, Operative Unit 4."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmelo","family":"Pirri","sequence":"additional","affiliation":[{"name":"Physical and Rehabilitation Medicine, Tor Vergata University of Rome, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Di Giunta","sequence":"additional","affiliation":[{"name":"Physical and Rehabilitation Medicine, Tor Vergata University of Rome, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Calogero","family":"Foti","sequence":"additional","affiliation":[{"name":"Physical and Rehabilitation Medicine, Tor Vergata University of Rome, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Traballesi","sequence":"additional","affiliation":[{"name":"Fondazione Santa Lucia, Scientific Institute for Research and Healthcare, Operative Unit 4."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"R1-20230918","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1161\/STROKEAHA.109.569483","article-title":"Randomized trial of treadmill walking with body weight support to establish walking in subacute stroke: the MOBILISE trial.","volume":"41","author":"Ada","year":"2010","journal-title":"Stroke"},{"key":"R2-20230918","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.1053\/apmr.2002.34618","article-title":"Rasch analysis of the Rivermead Mobility Index: a study using mobility measures of first-stroke inpatients.","volume":"83","author":"Antonucci","year":"2002","journal-title":"Arch Phys Med Rehabil"},{"key":"R3-20230918","doi-asserted-by":"crossref","first-page":"50","DOI":"10.3109\/03790799109166684","article-title":"The rivermead mobility index: a further development of the rivermead motor assessment.","volume":"13","author":"Collen","year":"1991","journal-title":"Int Disabil Stud"},{"key":"R4-20230918","doi-asserted-by":"crossref","first-page":"1914","DOI":"10.1016\/j.apmr.2010.08.025","article-title":"Balance, balance confidence, and health-related quality of life in persons with chronic stroke after body weight-supported treadmill training.","volume":"91","author":"Combs","year":"2010","journal-title":"Arch Phys Med Rehabil"},{"key":"R5-20230918","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1177\/0269215514520773","article-title":"Body weight-supported treadmill training vs. overground walking training for persons with chronic stroke: a pilot randomized controlled trial.","volume":"28","author":"Combs-Miller","year":"2014","journal-title":"Clin Rehabil"},{"key":"R6-20230918","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/S0004-9514(14)60268-3","article-title":"Practical issues in retraining walking in severely disabled patients using treadmill and harness support systems.","volume":"47","author":"Crompton","year":"2001","journal-title":"Aust J Physiother"},{"key":"R7-20230918","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/S1836-9553(10)70039-4","article-title":"Treadmill walking with body weight support in subacute non-ambulatory stroke improves walking capacity more than overground walking: a randomised trial.","volume":"56","author":"Dean","year":"2010","journal-title":"J Physiother"},{"key":"R8-20230918","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1080\/16501970410017215","article-title":"Reliability of gait performance tests in men and women with hemiparesis after stroke.","volume":"37","author":"Flansbjer","year":"2005","journal-title":"J Rehabil Med"},{"key":"R9-20230918","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1016\/j.apmr.2016.11.022","article-title":"Effects of gait training with body weight support on a treadmill versus overground in individuals with stroke.","volume":"98","author":"Gama","year":"2017","journal-title":"Arch Phys Med Rehabil"},{"key":"R10-20230918","doi-asserted-by":"crossref","first-page":"55","DOI":"10.3233\/NRE-2008-23106","article-title":"Treadmill training with partial body weight support after stroke: a review.","volume":"23","author":"Hesse","year":"2008","journal-title":"Neurorehabilitation"},{"key":"R11-20230918","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1161\/01.STR.26.6.976","article-title":"Treadmill training with partial body weight support compared with physiotherapy in nonambulatory hemiparetic patients.","volume":"26","author":"Hesse","year":"1995","journal-title":"Stroke"},{"key":"R12-20230918","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1191\/026921599673896297","article-title":"Gait pattern of severely disabled hemiparetic subjects on a new controlled gait trainer as compared to assisted treadmill walking with partial body weight support.","volume":"13","author":"Hesse","year":"1999","journal-title":"Clin Rehabil"},{"key":"R13-20230918","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1093\/ptj\/64.1.35","article-title":"Clinical gait assessment in the neurologically impaired. Reliability and meaningfulness.","volume":"64","author":"Holden","year":"1984","journal-title":"Phys Ther"},{"key":"R14-20230918","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1310\/tsr1804-293","article-title":"Importance of specificity, amount, and intensity of locomotor training to improve ambulatory function in patients poststroke.","volume":"18","author":"Hornby","year":"2011","journal-title":"Top Stroke Rehabil"},{"key":"R15-20230918","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1161\/01.STR.0000254607.48765.cb","article-title":"Effects of locomotion training with assistance of a robot-driven gait orthosis in hemiparetic patients after stroke: a randomized controlled pilot study.","volume":"38","author":"Husemann","year":"2007","journal-title":"Stroke"},{"key":"R16-20230918","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/S1474-4422(06)70495-1","article-title":"Clinical interpretation and use of stroke scales.","volume":"5","author":"Kasner","year":"2006","journal-title":"Lancet Neurol"},{"key":"R17-20230918","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1080\/02699050801895423","article-title":"Exercise and health-related quality of life during the first year following acute stroke. A randomized controlled trial.","volume":"22","author":"Langhammer","year":"2008","journal-title":"Brain Inj"},{"key":"R18-20230918","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1152\/japplphysiol.01380.2006","article-title":"Biomechanics of overground vs. treadmill walking in healthy individuals.","volume":"104","author":"Lee","year":"2008","journal-title":"J Appl Physiol (1985)"},{"key":"R19-20230918","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/S0031-9406(05)60026-0","article-title":"Effectiveness of treadmill retraining on gait of hemiparetic stroke patients: systematic review of current evidence.","volume":"89","author":"Manning","year":"2003","journal-title":"Physiotherapy"},{"key":"R20-20230918","first-page":"CD002840","article-title":"Treadmill training and body weight support for walking after stroke.","volume":"8","author":"Mehrholz","year":"2017","journal-title":"Cochrane Database Syst Rev"},{"key":"R21-20230918","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1093\/ptj\/82.1.53","article-title":"Body weight support treadmill and overground ambulation training for two patients with chronic disability secondary to stroke.","volume":"82","author":"Miller","year":"2002","journal-title":"Phys Ther"},{"key":"R22-20230918","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1177\/1545968311401034","article-title":"Who may benefit from robotic-assisted gait training? A randomized clinical trial in patients with subacute stroke.","volume":"25","author":"Morone","year":"2011","journal-title":"Neurorehabil Neural Repair"},{"key":"R24-20230918","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1191\/026921501680425234","article-title":"Walking training of patients with hemiparesis at an early stage after stroke: a comparison of walking training on a treadmill with body weight support and walking training on the ground.","volume":"15","author":"Nilsson","year":"2001","journal-title":"Clin Rehabil"},{"key":"R25-20230918","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1159\/000135648","article-title":"Quantification of the probability of reaching mobility independence at discharge from a rehabilitation hospital in nonwalking early ischemic stroke patients: a multivariate study.","volume":"26","author":"Paolucci","year":"2008","journal-title":"Cerebrovasc Dis"},{"key":"R26-20230918","first-page":"323","article-title":"Rehabilitation efficiency and destination on discharge after stroke.","volume":"50","author":"Pinedo","year":"2014","journal-title":"Eur J Phys Rehabil Med"},{"key":"R27-20230918","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/0895-4356(89)90065-6","article-title":"Improving the sensitivity of the Barthel Index for stroke rehabilitation.","volume":"42","author":"Shah","year":"1989","journal-title":"J Clin Epidemiol"},{"key":"R28-20230918","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1186\/1743-0003-8-48","article-title":"Gait training with partial body weight support during overground walking for individuals with chronic stroke: a pilot study.","volume":"8","author":"Sousa","year":"2011","journal-title":"J Neuroeng Rehabil"},{"key":"R29-20230918","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1053\/apmr.2002.32488","article-title":"Step training with body weight support: effect of treadmill speed and practice paradigms on poststroke locomotor recovery.","volume":"83","author":"Sullivan","year":"2002","journal-title":"Arch Phys Med Rehabil"},{"key":"R30-20230918","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1310\/UDXE-MJFF-53V2-EAP0","article-title":"Gait retraining post stroke.","volume":"10","author":"Teasell","year":"2003","journal-title":"Top Stroke Rehabil"},{"key":"R31-20230918","doi-asserted-by":"crossref","first-page":"141","DOI":"10.3233\/NRE-2001-16303","article-title":"Partial body weight treadmill training in persons with chronic stroke.","volume":"16","author":"Trueblood","year":"2001","journal-title":"Neurorehabilitation"},{"key":"R32-20230918","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1191\/0269215504cr843oa","article-title":"The impact of physical therapy on functional outcomes after stroke: what\u2019s the evidence?","volume":"18","author":"Van Peppen","year":"2004","journal-title":"Clin Rehabil"},{"key":"R33-20230918","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1161\/01.STR.29.6.1122","article-title":"A new approach to retrain gait in stroke patients through body weight support and treadmill stimulation.","volume":"29","author":"Visintin","year":"1998","journal-title":"Stroke"},{"key":"R34-20230918","doi-asserted-by":"crossref","first-page":"25","DOI":"10.2340\/1650197787192530","article-title":"Walking after stroke. Measurement and recovery over the first 3 months.","volume":"19","author":"Wade","year":"1987","journal-title":"Scand J Rehabil Med"}],"container-title":["International Journal of Rehabilitation Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/10.1097\/MRR.0000000000000363","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,18]],"date-time":"2023-09-18T06:30:56Z","timestamp":1695018656000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/10.1097\/MRR.0000000000000363"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12]]},"references-count":33,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019]]}},"URL":"https:\/\/doi.org\/10.1097\/mrr.0000000000000363","relation":{},"ISSN":["0342-5282"],"issn-type":[{"value":"0342-5282","type":"print"}],"subject":[],"published":{"date-parts":[[2019,12]]}}}