{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T18:10:49Z","timestamp":1793211049403,"version":"4.5.0"},"reference-count":30,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:p>This retrospective study aimed to predict dexterity at 3 and 6 months post-stroke by integrating clinical, neurophysiological, and neuroimaging factors. We included 126 patients with first-ever, unilateral, and supratentorial stroke. Demographic, stroke characteristics, and initial clinical assessment variables [Mini-mental state examination and Fugl\u2013Meyer Assessment Upper Extremity (FMA-UE)] were evaluated 2 weeks after stroke. Dexterity, measured using the Manual Function Test (MFT) hand subscore, was the primary outcome. The neurophysiological variables, upper limb somatosensory evoked potential (SEP) and motor evoked potential (MEP), were assessed 2 weeks post-stroke. The neuroimaging variable, fractional anisotropy (FA) of the corticospinal tract (CST), was assessed 3 weeks post-stroke. Multiple regression analysis revealed significant predictors for improved dexterity at 3 and 6 months post-stroke, including younger age, higher FMA-UE score, presence of waveforms in the SEP and MEP, and higher FA values in the CST (adjusted R<jats:sup>2<\/jats:sup>\u2005=\u20050.776, <jats:italic toggle=\"yes\">P<\/jats:italic>\u2005&lt;\u20050.001 at 3 months; adjusted R<jats:sup>2<\/jats:sup>\u2005=\u20050.668, <jats:italic toggle=\"yes\">P<\/jats:italic>\u2005&lt;\u20050.001 at 6 months; where MEP, SEP, and FA accounted together for an additional 0.079 and 0.166 of variance beyond age and FMA-UE, respectively). Subgroup analysis was conducted by categorizing the participants based on their initial hand function: those with no hand function (MFT hand subscore = 0) (N\u2005=\u200560) and those with a score &gt;0 (N\u2005=\u200551). Initial FMA-UE was a primary predictive factor regardless of the time point or initial severity, whereas the presence of MEP was a significant predictor only in the group with no initial hand dexterity.<\/jats:p>","DOI":"10.1097\/mrr.0000000000000601","type":"journal-article","created":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T08:02:08Z","timestamp":1693987328000},"page":"308-315","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":4,"title":["Predictors of manual dexterity at 3 and 6 months after stroke: integration of clinical, neurophysiological, and neuroimaging factors"],"prefix":"10.1097","volume":"46","author":[{"given":"Eui Jin","family":"Jeong","sequence":"first","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation, Korea University Anam Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mun Jeong","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation, Korea University Anam Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sekwang","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation, Korea University Anam Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeji","family":"Hwang","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Korea University College of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ju Seob","family":"Park","sequence":"additional","affiliation":[{"name":"Korea University College of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ki Min","family":"Kim","sequence":"additional","affiliation":[{"name":"Korea University College of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung-Bom","family":"Pyun","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation, Korea University Anam Hospital"},{"name":"Department of Biomedical Sciences, Korea University College of Medicine"},{"name":"Brain Convergence Research Center, Korea University College of Medicine, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2023,9,5]]},"reference":[{"key":"R1-20250525","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1186\/1471-2377-12-162","article-title":"Outcome and upper extremity function within 72 hours after first occasion of stroke in an unselected population at a stroke unit. 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