{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T06:33:26Z","timestamp":1793428406385,"version":"4.5.0"},"reference-count":34,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,12]]},"abstract":"<jats:sec>\n                    <jats:title\/>\n                    <jats:p>\n                      Following lower-limb loss (LLL), more than 50% of adults report multisite pain, that is, pain in two or more distinct sites, which is associated with self-reported activity restriction and higher fall risk. This study examined relationships between multisite pain and performance-based mobility among adults with LLL. During an outpatient Limb Loss Clinic, participants completed the timed up and go, the 10-m walk test, and the 6-min walk test. Linear regression modeling (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2005\u2264\u20050.0125) evaluated relationships between multisite pain and performance-based measures, considering covariates (e.g. age, sex, amputation level, and time since amputation). Of 112 adults greater than or equal to 6 months after LLL (55.2\u2005\u00b1\u200513.8 years; 77.7% male), 55.4% had multisite pain. Individuals with multisite pain had slower self-selected (\n                      <jats:italic toggle=\"yes\">b<\/jats:italic>\n                      \u2005=\u2005\u22120.126,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2005=\u20050.010) and fast (\n                      <jats:italic toggle=\"yes\">b<\/jats:italic>\n                      \u2005=\u2005\u22120.172,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2005=\u20050.012) gait speeds and shorter 6-min walk test distances (\n                      <jats:italic toggle=\"yes\">b<\/jats:italic>\n                      \u2005=\u2005\u221260.87,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2005=\u20050.010). Beyond covariates, multisite pain explained 4.2\u20135.0% of the variance in performance-based measures. Multisite pain should be considered when evaluating performance-based mobility following LLL.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1097\/mrr.0000000000000718","type":"journal-article","created":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T07:00:45Z","timestamp":1788850845000},"page":"278-285","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Multisite pain is related to performance-based function after lower-limb loss: a secondary analysis of cross-sectional data"],"prefix":"10.1097","volume":"49","author":[{"given":"Samantha J.","family":"Stauffer","sequence":"first","affiliation":[{"name":"Department of Physical Therapy, Delaware Limb Loss Studies, University of Delaware"},{"name":"Independence Prosthetics-Orthotics Inc."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan T.","family":"Pohlig","sequence":"additional","affiliation":[{"name":"University of Delaware, Biostatistics Core"},{"name":"University of Delaware, Epidemiology Program"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John R.","family":"Horne","sequence":"additional","affiliation":[{"name":"Independence Prosthetics-Orthotics Inc."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank B.","family":"Sarlo","sequence":"additional","affiliation":[{"name":"Christiana Spine Center, Newark, Delaware, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaclyn M.","family":"Sions","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy, Delaware Limb Loss Studies, University of 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