{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T22:27:21Z","timestamp":1792621641216,"version":"4.5.0"},"reference-count":28,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,7]]},"DOI":"10.1097\/nan.0000000000000050","type":"journal-article","created":{"date-parts":[[2014,7,2]],"date-time":"2014-07-02T01:34:10Z","timestamp":1404264850000},"page":"270-281","source":"Crossref","is-referenced-by-count":24,"title":["A Randomized Controlled Comparison of Flushing Protocols in Home Care Patients With Peripherally Inserted Central Catheters"],"prefix":"10.1097","volume":"37","author":[{"given":"Margaret G.","family":"Lyons","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann G.","family":"Phalen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"issue":"9","key":"R3-9-20210208","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1086\/671737","article-title":"The risk of bloodstream infection associated with peripherally inserted central catheters compared with central venous catheters in adults: a systematic review and meta-analysis.","volume":"34","author":"Chopra","year":"2013","journal-title":"Infect Control and Hosp Epidemiol"},{"key":"R4-9-20210208","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1016\/S1051-0443(07)61865-X","article-title":"Central venous catheters in home infusion care: outcomes analysis in 50,470 patients.","volume":"13","author":"Moureau","year":"2002","journal-title":"J Vasc Intervent Radiol"},{"issue":"6","key":"R5-9-20210208","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1097\/00129804-200411000-00005","article-title":"Peripherally inserted central catheters and midline catheters for the home care nurse.","volume":"27","author":"Gorski","year":"2004","journal-title":"J Infus Nurs"},{"issue":"3","key":"R6-9-20210208","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1097\/00129804-200605000-00003","article-title":"Technology of flushing vascular access devices.","volume":"29","author":"Hadaway","year":"2006","journal-title":"J Infus Nurs"},{"issue":"8","key":"R7-9-20210208","first-page":"324","article-title":"A meta-analysis of effects of heparin flush and saline flush: quality and cost implications.","volume":"40","author":"Goode","year":"1991","journal-title":"Nurs Res"},{"key":"R8-9-20210208","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/S0099-1767(97)90216-6","article-title":"Efficacy of normal saline solution versus heparin solution for maintaining patency of intravenous catheters in children.","volume":"23","author":"LeDuc","year":"1997","journal-title":"J Emerg Nurs"},{"key":"R9-9-20210208","first-page":"631","article-title":"Analysis of the research about heparinized verses nonheparinized intravascular lines.","volume":"20","author":"Peterson","year":"1991","journal-title":"Heart Lung"},{"key":"R10-9-20210208","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1136\/bmj.316.7136.969","article-title":"Benefit of heparin in peripheral venous and arterial catheters: systematic review and meta-analysis of randomised controlled trials.","volume":"316","author":"Randolph","year":"1998","journal-title":"Br Med J"},{"key":"R12-9-20210208","doi-asserted-by":"crossref","first-page":"30","DOI":"10.4037\/ccn2006.26.6.30","article-title":"Heparin-induced thrombocytopenia: advances in diagnosis and treatment.","volume":"26","author":"Cooney","year":"2006","journal-title":"Crit Care Nurs"},{"issue":"4","key":"R13-9-20210208","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1177\/0148607110362082","article-title":"Does low-dose heparin maintain central venous access device patency A comparison of heparin versus saline during a period of heparin shortage.","volume":"34","author":"Jonker","year":"2010","journal-title":"J Parenter Enteral Nutr"},{"issue":"1","key":"R15-9-20210208","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1097\/01.NAN.0000308542.90615.c2","article-title":"Comparison of occlusion rates by flushing solutions for peripherally inserted central catheters with positive pressure luer-activated devices.","volume":"31","author":"Bowers","year":"2008","journal-title":"J Infus Nurs"},{"issue":"7","key":"R20-9-20210208","doi-asserted-by":"crossref","first-page":"1918","DOI":"10.1200\/JCO.2002.07.131","article-title":"Safe and cost effective use of alteplase for the clearance of occluded central venous access devices.","volume":"20","author":"Timoney","year":"2002","journal-title":"J Clin Oncol"},{"issue":"4","key":"R21-9-20210208","first-page":"1","article-title":"Rates of clinically apparent heparin-induced thrombocytopenia for unfractionated heparin vs low molecular weight heparin in nonsurgical patients are low and similar.","volume":"3","author":"Locke","year":"2005","journal-title":"Thromb J"},{"key":"R23-9-20210208","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0140-6736(09)60220-8","article-title":"Management of occlusion and thrombosis associated with long-term indwelling central venous catheters.","volume":"374","author":"Baskin","year":"2009","journal-title":"Lancet"},{"key":"R24-9-20210208","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1111\/j.1751-553X.2007.00931.x","article-title":"Guidelines on the insertion and management of central venous access devices in adults.","volume":"29","author":"Bishop","year":"2007","journal-title":"Inter J Labor Hematol"},{"key":"R25-9-20210208","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/j.ajic.2009.10.001","article-title":"National healthcare safety network (NHSN) report: data summary for 2006-2008.","volume":"37","author":"Edwards","year":"2009","journal-title":"Am J Infect Control"},{"key":"R27-9-20210208","doi-asserted-by":"crossref","first-page":"S22","DOI":"10.1086\/591059","article-title":"Strategies to prevent central line-associated bloodstream infection in acute care hospitals.","volume":"29","author":"Marschall","year":"2008","journal-title":"Infect Control Hosp Epidemiol"},{"key":"R29-9-20210208","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1086\/599376","article-title":"Clinical practice guidelines for the diagnosis and management of intravascular catheter-related infection: 2009 update by the Infectious Diseases Society of America.","volume":"49","author":"Mermel","year":"2009","journal-title":"Clin Inf Dis"},{"key":"R30-9-20210208","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1086\/502213","article-title":"SHEA. SHEA guideline for preventing nosocomial transmission of multidrug-resistant strains of staphylococcus aureus and enterococcus.","volume":"24","author":"Muto","year":"2003","journal-title":"Infect Control Hosp Epidemiol"},{"issue":"suppl 1","key":"R32-9-20210208","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1016\/S0195-6701(07)60002-4","article-title":"Epic 2: national evidence-based guidelines for preventing hospital-associated infections in NHS hospitals in England.","volume":"65","author":"Pratt","year":"2007","journal-title":"J Hosp Infect"},{"key":"R34-9-20210208","doi-asserted-by":"crossref","first-page":"819","DOI":"10.7326\/0003-4819-119-8-199310150-00008","article-title":"Hypercoagulable states.","volume":"119","author":"Nachman","year":"1993","journal-title":"Ann Intern Med"},{"issue":"2","key":"R35-9-20210208","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.jcrc.2005.04.005","article-title":"Randomization and allocation concealment: a practical guide for researchers.","volume":"20","author":"Doig","year":"2005","journal-title":"J Crit Care"},{"key":"R37-9-20210208","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1097\/00003246-200204000-00033","article-title":"Fibrin sheath enhances central venous catheter infection.","volume":"30","author":"Mehall","year":"2002","journal-title":"Crit Care Med"},{"key":"R38-9-20210208","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1056\/NEJMra0801082","article-title":"Mechanisms of thrombus formation.","volume":"359","author":"Furie","year":"2008","journal-title":"N Engl J Med"},{"issue":"suppl 1","key":"R39-9-20210208","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1111\/j.1439-0507.2011.02149.x","article-title":"Candida biofilms associated with CVC and medical devices.","volume":"55","author":"Chandra","year":"2012","journal-title":"Mycoses"},{"issue":"4","key":"R40-9-20210208","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1177\/0148607108327526","article-title":"Biofilms, infection and parenteral nutrition therapy.","volume":"33","author":"Deh Carvalho Machado","year":"2009","journal-title":"J Parenter Enteral Nutr"},{"issue":"34","key":"R41-9-20210208","doi-asserted-by":"crossref","first-page":"24356","DOI":"10.1016\/S0021-9258(18)35773-9","article-title":"Complexation with heparin prevents adhesion between fibrin-coated surfaces.","volume":"267","author":"Retzinger","year":"1992","journal-title":"J Biol Chem"},{"issue":"2","key":"R42-9-20210208","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1177\/014860710603000285","article-title":"The impact of needless connector device design on central venous catheter occlusion in children: a prospective, controlled trial.","volume":"30","author":"Schilling","year":"2006","journal-title":"J Parenter Enteral Nutr"}],"container-title":["Journal of Infusion Nursing"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/10.1097\/NAN.0000000000000050","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,14]],"date-time":"2021-05-14T04:23:28Z","timestamp":1620966208000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/00129804-201407000-00009"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7]]},"references-count":28,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2014]]}},"URL":"https:\/\/doi.org\/10.1097\/nan.0000000000000050","relation":{},"ISSN":["1533-1458"],"issn-type":[{"value":"1533-1458","type":"print"}],"subject":[],"published":{"date-parts":[[2014,7]]}}}