{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T15:04:06Z","timestamp":1779116646850,"version":"3.51.4"},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Neuropathol Exp Neurol"],"published-print":{"date-parts":[[2007,7]]},"DOI":"10.1097\/nen.0b013e318093e521","type":"journal-article","created":{"date-parts":[[2008,5,4]],"date-time":"2008-05-04T08:44:55Z","timestamp":1209890695000},"page":"576-584","source":"Crossref","is-referenced-by-count":23,"title":["Human Retinal Pigment Epithelial Cell Implants Ameliorate Motor Deficits in Two Rat Models of Parkinson Disease"],"prefix":"10.1093","volume":"66","author":[{"given":"Ivan L.","family":"Cepeda","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph","family":"Flores","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael L.","family":"Cornfeldt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John R.","family":"O'Kusky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Doris J.","family":"Doudet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2007,7,1]]},"reference":[{"key":"2016030304000409000_66.7.576.1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1113"},{"key":"2016030304000409000_66.7.576.2","unstructured":"Hornykiewicz O . Advances in neurochemistry and pharmacology of Parkinson's disease. In: Cotzias GC McDowell FH eds. Developments in Treatment for Parkinson's Disease. New York: Medcom Press, 1971:24\u201349"},{"key":"2016030304000409000_66.7.576.3","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-0618(01)00100-4"},{"key":"2016030304000409000_66.7.576.4","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410320721"},{"key":"2016030304000409000_66.7.576.5","doi-asserted-by":"crossref","unstructured":"Watts RL Raiser CD Stover NP Stereotaxic intrastriatal implantation of human retinal pigment epithelial (hRPE) cells attached to gelatin microcarriers: A potential new cell therapy for Parkinson's disease. J Neural Transm Suppl 2003:215\u201327","DOI":"10.1007\/978-3-7091-0643-3_14"},{"key":"2016030304000409000_66.7.576.6","doi-asserted-by":"crossref","unstructured":"Marmor MF Wolfensberger TJ . Structure, Function, and Disease of the Retinal Pigment Epithelium. New York: Oxford University Press, 1998","DOI":"10.1007\/978-94-011-5137-5_1"},{"key":"2016030304000409000_66.7.576.7","first-page":"136","article-title":"The biosynthesis of mammalian melanin","volume":"70","author":"Pawelek","year":"1982","journal-title":"Am Sci"},{"key":"2016030304000409000_66.7.576.8","doi-asserted-by":"crossref","unstructured":"Boulton M . Melanin and the retinal pigment epithelium. In: Marmor MF Wolfensberger TJ eds. Structure, Function, and Disease of the Retinal Pigment Epithelium. New York: Oxford University Press, 1998:68\u201385","DOI":"10.1007\/978-94-011-5137-5_4"},{"key":"2016030304000409000_66.7.576.9","first-page":"511","article-title":"Demonstration of tyrosinase in the adult bovine uveal tract and retinal pigment epithelium","volume":"17","author":"Dryja","year":"1978","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"2016030304000409000_66.7.576.10","doi-asserted-by":"publisher","DOI":"10.1006\/exer.1997.0443"},{"key":"2016030304000409000_66.7.576.11","doi-asserted-by":"crossref","first-page":"207","DOI":"10.3727\/096020198389979","article-title":"Striatal xenotransplantation of human retinal pigment epithelial cells attached to microcarriers in hemiparkinsonian rats ameliorates behavioral deficits without provoking a host immune response","volume":"11","author":"Subramanian","year":"2002","journal-title":"Cell Transplant"},{"key":"2016030304000409000_66.7.576.12","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(96)00262-X"},{"key":"2016030304000409000_66.7.576.13","doi-asserted-by":"publisher","DOI":"10.2741\/1217"},{"key":"2016030304000409000_66.7.576.14","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.62.12.1833"},{"key":"2016030304000409000_66.7.576.15","doi-asserted-by":"publisher","DOI":"10.1055\/s-2001-13125"},{"key":"2016030304000409000_66.7.576.16","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2004.06.009"},{"key":"2016030304000409000_66.7.576.17","doi-asserted-by":"crossref","unstructured":"Schallert T Tillerson JL . Intervention strategies for degeneration of dopamine neurons in parkinsonism: Optimizing behavioral assessment of outcome. In: Emerich DF Dean PR Sanberg PR eds. Central Nervous System Disease. Totowa, NJ: Humana Press, 2000:131\u201351","DOI":"10.1007\/978-1-59259-691-1_8"},{"key":"2016030304000409000_66.7.576.18","unstructured":"Schallert T Woodlee MT Fleming SM . Disentangling multiple types of recovery from brain injury. In: Krieglstein J Klumpp S eds. Pharmacology of Cerebral Ischemia. Stuttgart: Medpharm Scientific Publishers, 2002:201\u201316"},{"key":"2016030304000409000_66.7.576.19","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2004.10.007"},{"key":"2016030304000409000_66.7.576.20","doi-asserted-by":"crossref","first-page":"00","DOI":"10.1097\/nen.0b013e318093e53a","article-title":"Characterization and survival of long-term implants of human retinal pigment epithelial cells attached to gelatin microcarriers in a model of Parkinson's disease","volume":"66","author":"Flores","year":"2007","journal-title":"J Neuropath Exp Neurol"},{"key":"2016030304000409000_66.7.576.21","unstructured":"Paxinos G Watson C . The Rat Brain in Stereotaxic Coordinates. San Diego: Academic Press, 1997"},{"key":"2016030304000409000_66.7.576.22","unstructured":"Schallert T Woodlee MT . Orienting and placing. In: Whishaw IQ Kolb B eds. The Behavior of the Laboratory Rat: A Handbook With Tests. New York: Oxford University Press, 2005:129\u201340"},{"key":"2016030304000409000_66.7.576.23","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2004.06.008"},{"key":"2016030304000409000_66.7.576.24","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2005.01.019"},{"key":"2016030304000409000_66.7.576.25","first-page":"2","article-title":"Behavioral characterization of normal Sprague Dawley rat's forelimb and hindlimb motor function with two sensorimotor tests sensitive to nigrostriatal integrity (Abstract)","volume":"517","author":"Cepeda","year":"2005","journal-title":"Soc Neurosci Abstr"},{"key":"2016030304000409000_66.7.576.26","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2004.05.024"},{"key":"2016030304000409000_66.7.576.27","doi-asserted-by":"publisher","DOI":"10.1046\/j.0953-816x.2001.01843.x"},{"key":"2016030304000409000_66.7.576.28","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2004.10.012"},{"key":"2016030304000409000_66.7.576.29","first-page":"1590","article-title":"Human retinal pigment epithelial cell-induced apoptosis in activated T cells","volume":"39","author":"Jorgensen","year":"1998","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"2016030304000409000_66.7.576.30","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2004.02.015"},{"key":"2016030304000409000_66.7.576.31","doi-asserted-by":"publisher","DOI":"10.1126\/science.6810464"},{"key":"2016030304000409000_66.7.576.32","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4827(90)90007-W"},{"key":"2016030304000409000_66.7.576.33","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-4835(05)80004-1"}],"container-title":["Journal of Neuropathology & Experimental Neurology"],"original-title":[],"language":"en","deposited":{"date-parts":[[2019,5,10]],"date-time":"2019-05-10T22:21:42Z","timestamp":1557526902000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jnen\/article-lookup\/doi\/10.1097\/nen.0b013e318093e521"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,7]]},"references-count":33,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2007,7,1]]},"published-print":{"date-parts":[[2007,7]]}},"alternative-id":["10.1097\/nen.0b013e318093e521"],"URL":"https:\/\/doi.org\/10.1097\/nen.0b013e318093e521","relation":{},"ISSN":["0022-3069","1554-6578"],"issn-type":[{"value":"0022-3069","type":"print"},{"value":"1554-6578","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,7]]}}}