{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T16:27:30Z","timestamp":1790699250617,"version":"4.1.0"},"reference-count":56,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,3]]},"DOI":"10.1097\/npt.0b013e3182462ea6","type":"journal-article","created":{"date-parts":[[2013,7,4]],"date-time":"2013-07-04T05:04:06Z","timestamp":1372914246000},"page":"8-16","source":"Crossref","is-referenced-by-count":50,"title":["Evidence of Altered Corticomotor System Connectivity in Early-Stage Alzheimer's Disease"],"prefix":"10.1097","volume":"36","author":[{"given":"Eric D.","family":"Vidoni","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George P.","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robyn A.","family":"Honea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Loskutova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey M.","family":"Burns","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-3-20210126","first-page":"110","article-title":"Alzheimers disease facts and figures.","volume":"4","year":"2008","journal-title":"Alzheimers Dement"},{"key":"R2-3-20210126","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/BF00308809","article-title":"Neuropathological staging of Alzheimer-related changes.","volume":"82","author":"Braak","year":"1991","journal-title":"Acta Neuropathol (Berl)"},{"key":"R3-3-20210126","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1097\/00005072-199911000-00002","article-title":"Primary motor cortex involvement in Alzheimer disease.","volume":"58","author":"Suva","year":"1999","journal-title":"J Neuropathol Exp Neurol"},{"key":"R4-3-20210126","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1093\/geronb\/52B.1.P28","article-title":"Patterns of motor impairment in normal aging, mild cognitive decline, and early Alzheimers disease.","volume":"52","author":"Kluger","year":"1997","journal-title":"J Gerontol B Psychol Sci Soc Sci"},{"key":"R5-3-20210126","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/S0006-8993(00)02635-4","article-title":"Visual feedback has differential effects on reaching movements in Parkinsons and Alzheimers disease.","volume":"876","author":"Ghilardi","year":"2000","journal-title":"Brain Res"},{"key":"R6-3-20210126","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1037\/0894-4105.11.2.261","article-title":"Patients with Alzheimers disease who cannot perform some motor skills show normal learning of other motor skills.","volume":"11","author":"Willingham","year":"1997","journal-title":"Neuropsychology"},{"key":"R7-3-20210126","first-page":"196","article-title":"Walking difficulties in patients with Alzheimers disease might originate from gait apraxia.","volume":"75","author":"Della Sala","year":"2004","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"R8-3-20210126","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1002\/gps.547","article-title":"Non-neurological factors are implicated in impairments in gait and mobility among patients in a clinical dementia referral population.","volume":"17","author":"Thomas","year":"2002","journal-title":"Int J Geriatr Psychiatry"},{"key":"R9-3-20210126","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1212\/WNL.45.5.908","article-title":"Maintenance of balance, gait patterns, and obstacle clearance in Alzheimers disease.","volume":"45","author":"Alexander","year":"1995","journal-title":"Neurology"},{"key":"R10-3-20210126","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.neuroscience.2005.08.079","article-title":"Comparison of motor strategies in sit-to-stand and back-to-sit motions between healthy and Alzheimers disease elderly subjects.","volume":"137","author":"Manckoundia","year":"2006","journal-title":"Neuroscience"},{"key":"R11-3-20210126","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1002\/hbm.20883","article-title":"Sensorimotor network rewiring in mild cognitive impairment and Alzheimers disease.","volume":"31","author":"Agosta","year":"2010","journal-title":"Hum Brain Mapp"},{"key":"R12-3-20210126","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1155\/2007\/845914","article-title":"Movements execution in amnestic mild cognitive impairment and Alzheimers disease.","volume":"18","author":"Camarda","year":"2007","journal-title":"Behav Neurol"},{"key":"R13-3-20210126","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1037\/0735-7044.118.4.698","article-title":"Cortical networks generating movement-related EEG rhythms in Alzheimers disease: an EEG coherence study.","volume":"118","author":"Babiloni","year":"2004","journal-title":"Behav Neurosci"},{"key":"R14-3-20210126","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.brainresbull.2005.10.013","article-title":"Fronto-parietal coupling of brain rhythms in mild cognitive impairment: a multicentric EEG study.","volume":"69","author":"Babiloni","year":"2006","journal-title":"Brain Res Bull"},{"key":"R15-3-20210126","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/j.biopsych.2004.12.031","article-title":"Event-related functional magnetic resonance imaging investigation of executive control in very old individuals with mild cognitive impairment.","volume":"57","author":"Rosano","year":"2005","journal-title":"Biol Psychiatry"},{"key":"R16-3-20210126","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1093\/geronb\/51B.2.P103","article-title":"Acquisition and long-term retention of a gross motor skill in Alzheimers disease patients under constant and varied practice conditions.","volume":"51","author":"Dick","year":"1996","journal-title":"J Gerontol B Psychol Sci Soc Sci"},{"key":"R17-3-20210126","first-page":"470","article-title":"The variability of practice hypothesis in motor learning: does it apply to Alzheimers disease Brain Cogn.","volume":"44","author":"Dick","year":"2000","journal-title":""},{"key":"R18-3-20210126","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/S0028-3932(96)00081-4","article-title":"Response programming in dementia of the Alzheimer type: a kinematic analysis.","volume":"35","author":"Bellgrove","year":"1997","journal-title":"Neuropsychologia"},{"key":"R19-3-20210126","doi-asserted-by":"crossref","first-page":"517","DOI":"10.3233\/JAD-2010-1245","article-title":"Neural correlates of impaired functional independence in early Alzheimers disease.","volume":"19","author":"Vidoni","year":"2010","journal-title":"J Alzheimers Dis"},{"key":"R20-3-20210126","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1111\/j.1532-5415.1997.tb03091.x","article-title":"Cognitive markers preceding Alzheimers dementia in the healthy oldest old.","volume":"45","author":"Howieson","year":"1997","journal-title":"J Am Geriatr Soc"},{"key":"R21-3-20210126","doi-asserted-by":"crossref","first-page":"3238","DOI":"10.1002\/hbm.20744","article-title":"Structural MRI biomarkers for preclinical and mild Alzheimers disease.","volume":"30","author":"Fennema-Notestine","year":"2009","journal-title":"Hum Brain Mapp"},{"key":"R22-3-20210126","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1002\/gps.1873","article-title":"Early detection of Alzheimers disease: a new working memory paradigm.","volume":"23","author":"Toepper","year":"2008","journal-title":"Int J Geriatr Psychiatry"},{"key":"R23-3-20210126","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1212\/01.wnl.0000277292.37292.69","article-title":"Relationship of fMRI activation to clinical trial memory measures in Alzheimer disease.","volume":"69","author":"Diamond","year":"2007","journal-title":"Neurology"},{"key":"R24-3-20210126","doi-asserted-by":"crossref","first-page":"541","DOI":"10.2174\/156720509790147106","article-title":"Impact of Alzheimers disease on the functional connectivity of spontaneous brain activity.","volume":"6","author":"Sorg","year":"2009","journal-title":"Curr Alzheimer Res"},{"key":"R25-3-20210126","first-page":"103","article-title":"Detection of PCC functional connectivity characteristics in resting-state fMRI in mild Alzheimers disease. Behav Brain Res.","volume":"197","author":"Zhang","year":"2009","journal-title":"J"},{"key":"R26-3-20210126","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.jalz.2008.04.006","article-title":"Abnormal connectivity in the posterior cingulate and hippocampus in early Alzheimers disease and mild cognitive impairment.","volume":"4","author":"Zhou","year":"2008","journal-title":"Alzheimers Dement"},{"key":"R27-3-20210126","doi-asserted-by":"crossref","first-page":"4637","DOI":"10.1073\/pnas.0308627101","article-title":"Default-mode network activity distinguishes Alzheimers disease from healthy aging: evidence from functional MRI.","volume":"101","author":"Greicius","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R28-3-20210126","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/j.neuroimage.2005.12.033","article-title":"Changes in hippocampal connectivity in the early stages of Alzheimers disease: evidence from resting state fMRI.","volume":"31","author":"Wang","year":"2006","journal-title":"Neuroimage"},{"key":"R29-3-20210126","doi-asserted-by":"crossref","first-page":"18760","DOI":"10.1073\/pnas.0708803104","article-title":"Selective changes of resting-state networks in individuals at risk for Alzheimers disease.","volume":"104","author":"Sorg","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R30-3-20210126","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1212\/WNL.0b013e31820af94e","article-title":"Default mode network connectivity in stable vs progressive mild cognitive impairment.","volume":"76","author":"Petrella","year":"2011","journal-title":"Neurology"},{"key":"R31-3-20210126","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1155\/2009\/610392","article-title":"Large-scale functional brain network abnormalities in Alzheimers disease: insights from functional neuroimaging.","volume":"21","author":"Dickerson","year":"2009","journal-title":"Behav Neurol"},{"key":"R32-3-20210126","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/j.neuroimage.2004.09.007","article-title":"The neural correlates and functional integration of cognitive control in a Stroop task.","volume":"24","author":"Egner","year":"2005","journal-title":"Neuroimage"},{"key":"R33-3-20210126","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1212\/01.wnl.0000317094.86209.cb","article-title":"Cardiorespiratory fitness and brain atrophy in early Alzheimer disease.","volume":"71","author":"Burns","year":"2008","journal-title":"Neurology"},{"key":"R34-3-20210126","doi-asserted-by":"crossref","first-page":"2412b","DOI":"10.1212\/WNL.43.11.2412-a","article-title":"The Clinical Dementia Rating (CDR): current version and scoring rules.","volume":"43","author":"Morris","year":"1993","journal-title":"Neurology"},{"key":"R35-3-20210126","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1212\/WNL.34.7.939","article-title":"Clinical diagnosis of Alzheimers disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimers disease.","volume":"34","author":"McKhann","year":"1984","journal-title":"Neurology"},{"key":"R36-3-20210126","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1093\/geronj\/37.3.323","article-title":"Measurement of functional activities in older adults in the community.","volume":"37","author":"Pfeffer","year":"1982","journal-title":"J Gerontol"},{"key":"R37-3-20210126","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1002\/ana.410070516","article-title":"Pathological verification of ischemic score in differentiation of dementias.","volume":"7","author":"Rosen","year":"1980","journal-title":"Ann Neurol"},{"key":"R38-3-20210126","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1016\/j.neuroimage.2003.10.038","article-title":"Voxel-based homogeneity probability maps of gray matter in groups: assessing the reliability of functional effects.","volume":"21","author":"Momenan","year":"2004","journal-title":"Neuroimage"},{"key":"R39-3-20210126","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1002\/(SICI)1097-0193(1997)5:4<238::AID-HBM6>3.0.CO;2-4","article-title":"Automated labeling of the human brain: a preliminary report on the development and evaluation of a forward-transform method.","volume":"5","author":"Lancaster","year":"1997","journal-title":"Hum Brain Mapp"},{"key":"R40-3-20210126","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1016\/S1053-8119(03)00169-1","article-title":"An automated method for neuroanatomic and cytoarchitectonic atlas-based interrogation of fMRI data sets.","volume":"19","author":"Maldjian","year":"2003","journal-title":"Neuroimage"},{"key":"R41-3-20210126","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1006\/nimg.1997.0269","article-title":"Cognitive conjunction: a new approach to brain activation experiments.","volume":"5","author":"Price","year":"1997","journal-title":"Neuroimage"},{"key":"R43-3-20210126","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1002\/hbm.10040","article-title":"Motor cortex activation is related to force of squeezing.","volume":"16","author":"Cramer","year":"2002","journal-title":"Hum Brain Mapp"},{"key":"R44-3-20210126","doi-asserted-by":"crossref","first-page":"2453","DOI":"10.1002\/hbm.20676","article-title":"Differential force scaling of fine-graded power grip force in the sensorimotor network.","volume":"30","author":"Keisker","year":"2009","journal-title":"Hum Brain Mapp"},{"key":"R45-3-20210126","doi-asserted-by":"crossref","first-page":"2136","DOI":"10.1016\/S0028-3932(02)00053-2","article-title":"Evidence for cortical encoding specificity in episodic memory: memory-induced re-activation of picture processing areas.","volume":"40","author":"Vaidya","year":"2002","journal-title":"Neuropsychologia"},{"key":"R46-3-20210126","doi-asserted-by":"crossref","first-page":"1889","DOI":"10.1016\/j.neurobiolaging.2006.08.008","article-title":"Increased fMRI responses during encoding in mild cognitive impairment.","volume":"28","author":"Hamalainen","year":"2007","journal-title":"Neurobiol Aging"},{"key":"R47-3-20210126","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1002\/ana.10416","article-title":"Motor cortex excitability in Alzheimers disease: a transcranial magnetic stimulation study.","volume":"53","author":"Ferreri","year":"2003","journal-title":"Ann Neurol"},{"key":"R48-3-20210126","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1097\/00005072-200606000-00010","article-title":"Visual association pathology in preclinical Alzheimer disease.","volume":"65","author":"McKee","year":"2006","journal-title":"J Neuropathol Exp Neurol"},{"key":"R49-3-20210126","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/S0035-3787(04)70849-8","article-title":"Dual task effects of walking when talking in Alzheimers disease.","volume":"160","author":"Cocchini","year":"2004","journal-title":"Rev Neurol (Paris)"},{"issue":"2","key":"R50-3-20210126","doi-asserted-by":"crossref","first-page":"503","DOI":"10.3233\/JAD-2010-1244","article-title":"Dual task during encoding, maintenance, and retrieval in Alzheimers disease.","volume":"19","author":"Della Sala","year":"2010","journal-title":"J Alzheimers Dis"},{"key":"R51-3-20210126","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1016\/S0010-9452(08)70685-3","article-title":"Specific AD impairment in concurrent performance of two memory tasks.","volume":"43","author":"MacPherson","year":"2007","journal-title":"Cortex"},{"key":"R52-3-20210126","doi-asserted-by":"crossref","first-page":"1860","DOI":"10.1007\/s00415-009-5210-7","article-title":"Alzheimers disease, but not ageing or depression, affects dual-tasking.","volume":"256","author":"Kaschel","year":"2009","journal-title":"J Neurol"},{"key":"R53-3-20210126","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1159\/000275674","article-title":"Treatment effects of therapeutic cholinesterase inhibitors on visuospatial processing in Alzheimers disease: a longitudinal functional MRI study.","volume":"29","author":"Thiyagesh","year":"2010","journal-title":"Dement Geriatr Cogn Disord"},{"key":"R54-3-20210126","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1111\/j.1460-9568.2007.05358.x","article-title":"Preliminary sex differences in human cortical BOLD fMRI activity during the preparation of increasingly complex visually guided movements.","volume":"25","author":"Gorbet","year":"2007","journal-title":"Eur J Neurosci"},{"key":"R55-3-20210126","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1006\/nimg.2000.0602","article-title":"Movement-related electroencephalographic reactivity in Alzheimer disease.","volume":"12","author":"Babiloni","year":"2000","journal-title":"Neuroimage"},{"key":"R56-3-20210126","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.rehab.2008.10.004","article-title":"The value of instrumental gait analysis in elderly healthy, MCI or Alzheimers disease subjects and a comparison with journal clinical tests used in single and dual-task conditions.","volume":"52","author":"Gillain","year":"2009","journal-title":"Ann Phys Rehabil Med"},{"key":"R57-3-20210126","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1001\/archneur.65.8.1091","article-title":"Staging dementia using Clinical Dementia Rating Scale Sum of Boxes scores: a Texas Alzheimers research consortium study.","volume":"65","author":"OBryant","year":"2008","journal-title":"Arch Neurol"}],"container-title":["Journal of Neurologic Physical Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/10.1097\/NPT.0b013e3182462ea6","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T20:51:43Z","timestamp":1715633503000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/01253086-201203000-00003"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,3]]},"references-count":56,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012]]}},"URL":"https:\/\/doi.org\/10.1097\/npt.0b013e3182462ea6","relation":{},"ISSN":["1557-0576"],"issn-type":[{"value":"1557-0576","type":"print"}],"subject":[],"published":{"date-parts":[[2012,3]]}}}