{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,11]],"date-time":"2025-07-11T10:13:06Z","timestamp":1752228786418},"reference-count":9,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:sec>\n            <jats:title>Background:<\/jats:title>\n            <jats:p>Mononeuritis multiplex due to hepatitis C infection and cryoglobulinemia has no specific treatment guidelines. Despite the favorable evolution of the liver disease after treatment with interferon and ribavirin, neurological symptoms might not respond very efficiently to antiviral therapy.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Case Report:<\/jats:title>\n            <jats:p>We report the case of a 50-year-old woman, with a mononeuritis multiplex related to cryoglobulinemia and hepatitis C virus infection, who was treated with rituximab. Hepatitis C virus infection was treated successfully with interferon-\u03b1 and ribavirin, but the neurological symptoms were still worsening until rituximab therapy. Significant improvement of paraparesis and painful hypoesthesia were evident after the fourth infusion of rituximab. However, every 6 months, the neurological symptoms relapsed and the patient was subjected to a new cycle of rituximab therapy, with the disappearing of the paraparesis and hypoesthesias.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions:<\/jats:title>\n            <jats:p>This case highlights the potential use of rituximab in immune-mediated neuropathies, especially the mononeuritis multiplex associated with hepatitis C infection.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1097\/nrl.0000000000000075","type":"journal-article","created":{"date-parts":[[2016,4,26]],"date-time":"2016-04-26T13:07:38Z","timestamp":1461676058000},"page":"47-48","source":"Crossref","is-referenced-by-count":3,"title":["Refractory Mononeuritis Multiplex Due to Hepatitis C Infection and Cryoglobulinemia"],"prefix":"10.1097","volume":"21","author":[{"given":"Cristiane N.","family":"Soares","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"R1-20230929","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1097\/NRL.0b013e31815fa594","article-title":"Neurologic complications of hepatitis C","volume":"14","author":"Acharya","year":"2008","journal-title":"Neurologist"},{"issue":"3A","key":"R2-20230929","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1590\/S0004-282X2006000400014","article-title":"Peripheral neuropathy in patients with hepatitis virus C infection in the Amazon region","volume":"64","author":"Gomes","year":"2006","journal-title":"Arq Neuropsiquiatr"},{"key":"R3-20230929","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1136\/jnnp.74.9.1267","article-title":"Peripheral neuropathy in hepatitis C virus infection with and without cryoglobulinaemia","volume":"74","author":"Nemni","year":"2003","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"R4-20230929","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1136\/jnnp.2005.081570","article-title":"Prevalence and characteristics of peripheral neuropathy in hepatitis C virus population","volume":"77","author":"Santoro","year":"2006","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"R5-20230929","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1196\/annals.1361.121","article-title":"Response of vasculitic peripheral neuropathy to intravenous immunoglobulin","volume":"1051","author":"Levy","year":"2005","journal-title":"Ann N Y Acad Sci"},{"key":"R6-20230929","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1136\/jnnp.74.4.485","article-title":"Treatment of IgM antibody associated polyneuropathies using rituximab","volume":"74","author":"Pestronk","year":"2003","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"R7-20230929","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1136\/ard.2006.065565","article-title":"Anti-CD20 monoclonal antibody (rituximab) treatment for cryoglobulinemic vasculitis: where do we stand?","volume":"67","author":"Cacoub","year":"2008","journal-title":"Ann Rheum Dis"},{"key":"R8-20230929","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.jcv.2009.10.006","article-title":"Acute wrist and foot drop associated with hepatitis C virus related mixed cryoglobulinemia: rapid response to treatment with rituximab","volume":"47","author":"Uppal","year":"2010","journal-title":"J Clin Virol"},{"key":"R9-20230929","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1136\/ard.2002.004929","article-title":"Rituximab induces remission in refractory HCV associated cryoglobulinaemic vasculitis","volume":"62","author":"Lamprecht","year":"2003","journal-title":"Ann Rheum Dis"}],"container-title":["The Neurologist"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/00127893-201605000-00004","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T09:35:20Z","timestamp":1695980120000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/00127893-201605000-00004"}},"subtitle":["Efficient Response to Rituximab"],"short-title":[],"issued":{"date-parts":[[2016,5]]},"references-count":9,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016]]}},"URL":"https:\/\/doi.org\/10.1097\/nrl.0000000000000075","relation":{},"ISSN":["1074-7931"],"issn-type":[{"value":"1074-7931","type":"print"}],"subject":[],"published":{"date-parts":[[2016,5]]}}}